蛋白质计算设计：方法和应用展望

操帆, 陈耀晞, 缪阳洋, 张璐, 刘海燕

Computational protein design: perspectives in methods and applications

Fan CAO, Yaoxi CHEN, Yangyang MIAO, Lu ZHANG, Haiyan LIU

图2 给定主链优化氨基酸序列和侧链构象

Fig. 2 Optimization of amino acids sequences and side-chain conformations for a given backbone（For the input target backbone structures, the sequences with the lowest energies were found by searching the sequence andside chain conformational space, considering them the most likely to form the target structures）