蛋白质计算设计：方法和应用展望

操帆, 陈耀晞, 缪阳洋, 张璐, 刘海燕

Computational protein design: perspectives in methods and applications

Fan CAO, Yaoxi CHEN, Yangyang MIAO, Lu ZHANG, Haiyan LIU

图5 两种主链设计策略

Fig. 5 Two backbone design strategies（Up， Splicing with the native fragment into a new backbone. Down， Main chain design methods for optimizing statistical energy functions）