蛋白质计算设计：方法和应用展望

操帆, 陈耀晞, 缪阳洋, 张璐, 刘海燕

Computational protein design: perspectives in methods and applications

Fan CAO, Yaoxi CHEN, Yangyang MIAO, Lu ZHANG, Haiyan LIU

图6 蛋白质-蛋白质界面设计的基本步骤

Fig. 6 Basic steps of protein-protein interface design[The backbone conformation of the ligand protein (red) in complex with the target receptor (green) is first designed,then the residue types at the ligand protein interface are designed and optimized, resulting in the final design result (blue)]