蛋白质计算设计：方法和应用展望

操帆, 陈耀晞, 缪阳洋, 张璐, 刘海燕

Computational protein design: perspectives in methods and applications

Fan CAO, Yaoxi CHEN, Yangyang MIAO, Lu ZHANG, Haiyan LIU

图7 正设计与负设计

Fig. 7 Positive design versus negative design（Positive design only considers decreasing target state energy and does not consider other states. Negative design then needs to raise the energy of the other states so that their energy differences from the target state increase）