纪念王义翘教授：解脂耶氏酵母替代植物油脂的技术瓶颈及展望

徐鹏

In memory of Prof. Daniel I.C. Wang: Engineering Yarrowia lipolytica for the production of plant-based lipids: technical constraints and perspectives for a sustainable cellular agriculture economy

Peng XU

表1 产油酵母胞内积累油脂的分批发酵动力学描述

Tab. 1 Fermentation kinetics of the oil accumulation process in oleaginous yeast in batch culture

方程编号 Equation No.	方程 Equations	描述 Description
(1)	$μ = \frac{μ_{m a x} S}{K_{S} + S} (1 - \frac{γ P}{S Y_{P / S}})$	细胞比生长速率 Specific growth rate
(2)	$\frac{d}{d t} X (t) = μ X (t) - k_{d} X (t)$	非油脂生物量积累 Oil-free cell growth
(3)	$\frac{d}{d t} P (t) = (α μ + β) X (t)$	油脂积累 Lipid accumulation
(4)	$\frac{d}{d t} S (t) = - \frac{μ X (t)}{Y_{X / S}} - \frac{(α μ + β) X (t)}{Y_{P / S}}$	底物消耗 Substrate consumption
(5)	$X_{t o t a l} (t) = P (t) + X (t)$	总生物量 Total biomass
(6)	$θ (t) = \frac{P (t)}{P (t) + X (t)}$	动态含油量 Oil content
(7)	$Y_{p r o c e s s} (t) = \frac{P_{f} (t) - P_{0}}{S_{0} - S_{f} (t)}$	动态过程得率 Process yield
(8)	$r (t) = \frac{P_{f} (t) - P_{0}}{t_{f} - t_{0}}$	总的生产强度 Overall productivity