苄基异喹啉类生物碱的微生物合成研究进展及挑战

林芝, 胡致伟, 瞿旭东, 林双君

Advances and challenges in microbial production of benzylisoquinoline alkaloids

Zhi LIN, Zhiwei HU, Xudong QU, Shuangjun LIN

图1 BIA的骨架类型及其生物合成途径 （绿色框为BIA的7大骨架类型，紫色框内为BIA上游共性化合成途径及关键的分支点，红色表示关键中间体S-牛心果碱；实线表示生物合成途径已知，虚线表示生物合成途径未知）

Fig. 1 Skeletons of BIAs and the proposed pathways for their biosynthesis (The green box represents the seven skeletons of BIAs, and the purple box represents the shared-upstream synthetic pathway and key branch points for synthesizing BIAs. Red color indicates the key intermediate (S)-Reticuline. The solid and dashed lines show known and unknown pathways for the synthesis of BIAs, respectively)