苄基异喹啉类生物碱的微生物合成研究进展及挑战

林芝, 胡致伟, 瞿旭东, 林双君

Advances and challenges in microbial production of benzylisoquinoline alkaloids

Zhi LIN, Zhiwei HU, Xudong QU, Shuangjun LIN

图2 S-牛心果碱的微生物合成途径总结及代谢流示意图 （蓝色酶表示模拟天然生物合成途径的微生物合成BIA途径，红色酶和羟基代表人工设计的微生物合成BIA途径。加粗的箭头表示该步反应酶的底物识别较为宽泛；细箭头表示底物识别较为单一，下文同此）

Fig. 2 Pathway for the microbial synthesis of benzylisoquinoline alkaloids (The microbial synthesis pathway of BIAs with enzymes highlighted by blue color is a mimic of the natural biosynthetic pathway, while enzymes and hydroxyl highlighted with red color represent the artificially designed pathway for microbial synthesis of BIAs. The bold and thin arrows indicate that the substrate recognition of the enzyme is relatively broad and specific, respectively)