代谢工程改造微生物利用甲酸研究进展
Progress in metabolic engineering of microorganisms for the utilization of formate
（绿色底色的化合物为路径底物，粉色底色的化合物为路径产物）Acdh—乙醛脱氢酶；Acs—乙酰辅酶A合成酶；Agt—丙氨酸-乙醛酸转氨酶；CA—碳酸酐酶；Faldh—甲醛脱氢酶；Fch—次甲基四氢叶酸环水解酶；Fdh—甲酸脱氢酶；Fthfl—甲酸四氢叶酸连接酶；Ftl—甲酸四氢叶酸连接酶；GCS—甘氨酸裂解系统；Gldh—谷氨酸脱氢酶；GlyA—丝氨酸羟甲基转移酶；Gpt—谷氨酸-丙酮酸转氨酶；Hal—HOB醛缩酶；Hat—HOB转氨酶；Hsk—高丝氨酸激酶；Lta—苏氨酸醛缩酶；Madh—苹果酸脱氢酶；Mcl—苹果酰辅酶A裂解酶；Medh—甲醇脱氢酶；Mtd—亚甲基四氢叶酸脱氢酶；Mthfs—5，10-亚甲基四氢叶酸合成酶；Mtk—苹果酸硫激酶；Oxidative PPP—氧化戊糖磷酸途径；Pfk—磷酸果糖激酶；Ppc—PEP羧化酶；Pps—PEP合成酶；Prk—磷酸核酮糖激酶；Rubisco—核酮糖-1，5-二磷酸羧化酶；Sal—丝氨酸醛缩酶；Sda—丝氨酸脱氨酶；THF—四氢叶酸；Ts—苏氨酸合成酶；Zwf—6-磷酸葡萄糖脱氢酶
(compounds with a green background are pathway substrates; compounds with a pink background are pathway products) Acdh—acetaldehyde dehydrogenase; Acs—acetyl-CoA synthase; Agt—alanine-glyoxylate transaminase; CA—carbonic anhydrase; Faldh—formaldehyde dehydrogenase; Fch—methenyl-tetrahydrofolate cyclohydrolase; Fdh—formate dehydrogenase; Fthfl—formate-tetrahydrofolate ligase; Ftl—formate-tetrahydrofolate ligase; GCS—glycine cleavage system; Gldh—glutamate dehydrogenase; GlyA—serine hydroxymethyltransferase; Gpt—glutamate-pyruvate transaminase; Hal—4-hydroxy-2-oxobutanoate aldolase; Hat—4-hydroxy-2-oxobutanoate aminotransferase; Hsk—homoserine kinase; Lta—threonine aldolase; Madh—malate dehydrogenase; Mcl—malyl-CoA lyase; Medh—methanol dehydrogenase; Mtd—methylene-tetrahydrofolate dehydrogenase; Mthfs—5,10-methylene-tetrahydrofolate synthase; Mtk—malate thiokinase; Oxidative PPP—Oxidative pentose-phosphate pathway; Pfk—phosphofructokinase; Ppc—phosphoenolpyruvate carboxylase; Pps—phosphoenolpyruvate synthase; Prk—phosphoribulo kinase; Rubisco—ribulose-1,5-bisphosphate carboxylase; Sal—serine aldolase; Sda—serine deaminase; THF—tetrahydrofolate; Ts—threonine synthase; Zwf—glucose-6-phosphate dehydrogenase
