代谢工程改造微生物利用甲酸研究进展
程真真, 张健, 高聪, 刘立明, 陈修来

Progress in metabolic engineering of microorganisms for the utilization of formate
CHENG Zhenzhen, ZHANG Jian, GAO Cong, LIU Liming, CHEN Xiulai
表3 rTHF-rgcv途径的路径酶来源
Table 3 Source of pathway enzymes of the rTHF-rgcv pathway
菌株路径酶来源参考文献
Escherichia coli

Ftl、Fch、Mtd(源自Clostridium ljungdahalii

GCS、GlyA、Sda(内源酶)

[61]
Escherichia coli

Ftl、Fch、Mtd(源自Methylobacterium extorquens AM1)

GCS、GlyA(内源酶)

[62]
Escherichia coli

Ftl、Fch、Mtd(源自Methylobacterium extorquens CM4)

GCS、GlyA、Sda(内源酶)

Fdh(源自Candida boidinii

[63]
Escherichia coli

Ftl(源自Clostridium kluyveri

FolD(Fch/ Mtd)、GCS、GlyA(内源酶)

[64]
Escherichia coli

Ftl、Fch、Mtd(源自Methylobacterium extorquens AM1)

GCS、GlyA、Sda(内源酶)

Fdh(源自Pseudomonas sp.)

[17]

Escherichia coli

(Bang等[63]研究的进一步拓展)

Ftl、Fch、Mtd(源自Methylobacterium extorquens CM4)

GCS、GlyA、Sda(内源酶)

Fdh(源自Candida boidiniiArabidopsis thaliana

[18]

Escherichia coli

(Döring等[64]研究的进一步拓展)

Ftl(源自Clostridium kluyveri

FolD(Fch/ Mtd)、GCS、GlyA(内源酶)

[65]

Escherichia coli

(Kim等[17]研究的进一步拓展)

Ftl、Fch、Mtd(源自Methylobacterium extorquens AM1)

GCS、GlyA、Sda(内源酶)

Fdh(源自Pseudomonas sp. )

[66]
Saccharomyces cerevisiae

MIS1(Ftl/ Fch/ Mtd)、GCS(内源酶)

Fdh(内源酶)

[19]
Cupriavidus necator

Ftl、Fch、Mtd(源自Methylobacterium extorquens AM1)

GCS、GlyA、Sda(内源酶)

Fdh(内源酶)

[16]
Clostridium pasteurianum

GCS(源自Gottschalkia acidurici

Ftl、Fch、Mtd、GlyA、Sda(内源酶)

[89]
Pseudomonas putida

Ftl、Fch、Mtd(源自Methylobacterium extorquens AM1)

GCS、GlyA、Sda(内源酶)

Fdh(内源酶)

[70]