微生物合成二元醇研究进展

竺方欢, 岑雪聪, 陈振

Research progress of diols production by microbes

Fanghuan ZHU, Xuecong CEN, Zhen CHEN

图1 乙二醇的生物合成路径 （X1P—木糖醛酸-1-磷酸；R1P—核糖醛酸-1-磷酸。图中基因所编码的酶：serA—磷酸甘油酸脱氢酶；serC—磷酸丝氨酸氨基转移酶；serB—磷酸丝氨酸磷酸酶；sdC—丝氨酸脱羧酶；ao—胺氧化酶；agt—丝氨酸-乙醛酸氨基转移酶；mdlC—苯甲酰甲酸脱羧酶；fucO/yqhD—醇脱氢酶；xdh—D-木糖脱氢酶；xylB—木糖激酶；xylC—木糖醛酸酯酶；yjhG/yagF—D-木酮酸脱氢酶；yjhH/yagE—2-酮-3-脱氧-D-戊糖醛缩酶；xylA—D-木糖异构酶；khk-C—D-木糖醛激酶；aldoB—D-木糖醛糖-1-磷酸醛缩酶；dte—D-塔格糖异构酶；fucK—岩藻糖激酶；fucA/rhaD—D-核糖醛糖-1-磷酸醛缩酶）

Fig. 1 Biosynthetic pathways of EG (The enzymes encoded by the genes: serA, phosphoglycerate dehydrogenase; serC, phosphoserine aminotransferase; serB, phosphoserine phosphatase; sdC, L-serine decarboxylase; ao, amine oxidase; agt, serine-glyoxylate aminotransferase; mdlC, benzoylformate decarboxylase; fucO/yqhD, alcohol dehydrogenase; xdh, D-xylose dehydrogenase; xylB, xylulokinase; xylC, xylonolactonase; yjhG/yagF, D-xylonate dehydrogenase; yjhH/yagE, 2-keto-3-deoxy-D-pentose aldolase; xylA, D-xylose isomerase; khk-C, D-xylulose kinase; aldoB, D-xylulose-1-phosphate aldolase; dte, D-tagatose epimerase; fucK, fuculokinase; fucA/rhaD, D-ribulose 1-phosphate aldolase)