酵母甘露糖蛋白的研究进展

盛周煌, 陈智仙, 张彦

Research progress of yeast mannoprotein

Zhouhuang SHENG, Zhixian CHEN, Yan ZHANG

图3 酵母甘露糖蛋白的生物合成途径 （Glu—葡萄糖；G6-P—葡萄糖-6-磷酸；PGM1—磷酸葡萄糖变位酶；G1-P—葡萄糖-1-磷酸；UGP1—尿苷二磷酸葡萄糖焦磷酸酶；UDP-Glu—尿苷二磷酸葡萄糖；PGI1—磷酸葡萄糖异构酶；F6-P—果糖-6-磷酸；M6-P—甘露糖-6-磷酸；PMI40—磷酸甘露糖变位酶；SEC53—磷酸甘露糖酶；M1-P—甘露糖-1-磷酸；PSA1—鸟苷二磷酸甘露糖焦磷酸酶；GDP-Man—鸟苷二磷酸甘露糖；UDP-GlcNAc—尿苷二磷酸-N-乙酰葡糖胺；Dol-P—磷酸多萜醇；Alg—糖基化转移酶；OST—寡糖基转移酶；G-Ⅰ/G-Ⅱ—α-葡萄糖苷酶；ERMan1—内质网甘露糖苷酶I；MGAT—甘露糖基糖蛋白-N-乙酰氨基葡萄糖转移酶；DPM—多萜醇磷酸甘露糖合成酶；PMT—甘露糖转移酶）

Fig. 3 The biosynthetic pathway of yeast mannoprotein (Glu—glucose;G6-P—glucose-6-phosphat;PGM1—Phosphoglucomutase;G1-P—glucose-1-phosphat;UGP1—uridine diphosphate glucose pyrophosphatase;UDP-Glu—uridine diphosphate glucose;PGI1—phosphoglucose isomerase;F6-P—fructose-6-phosphate;M6-P—mannose-6-phosphate;PMI40—mannose phosphate isomerase;SEC53—phosphomannomutase;M1-P—mannose-1-phosphate;PSA1—guanosine diphosphate mannose pyrophosphatase;GDP-Man—guanosine diphosphate mannose;UDP-GlcNAc—uridine diphosphate-N-acetylglucosamine;Dol-P—dolichol phosphate;Alg—glycosyltransferase;OST—oligosaccharides transferase;G-Ⅰ/G-Ⅱ—α- glucosidase;ERMan1—Endoplasmic reticulum mannosidase I;MGAT—mannosyl-glycoprotein-N-acetylglucosaminyltransferase;DPM—dolichol phosphate mannose synthase;PMT—mannosyltransferase)