近十年天然产物药物的生物合成研究进展

冯金, 潘海学, 唐功利

Research advances in biosynthesis of natural product drugs within the past decade

Jin FENG, Haixue PAN, Gongli TANG

图3 胆酸和去氧胆酸的生物合成 CYP7A1—胆固醇7α-羟化酶；HSD3B7—3β-羟基-Δ5-C27-类固醇氧化还原酶；CYP8B1—12α-羟化酶；AKR1D1—Δ5-3-氧代类固醇5β-还原酶；AKR1C4—3α-羟基类固醇脱氢酶；CYP27A1—甾醇27-羟化酶；CH25H—甾醇25-羟化酶；CYP46A1—24β-羟化酶

Fig. 3 Biosynthesis of cholic and deoxycholic acids CYP7A1—cholesterol 7α-hydroxylase; HSD3B7—3β-hydroxy-Δ5-C27-steroid oxidoreductase; CYP8B1—12α-hydroxylase; AKR1D1—Δ5-3-oxosteroid 5β-reductase; AKR1C4—3α-hydroxysteroid dehydrogenase; CYP27A1—sterol 27-hydroxylase; CH25H—sterol 25-hydroxylase; CYP46A1—24β-hydroxylase