近十年天然产物药物的生物合成研究进展

冯金, 潘海学, 唐功利

Research advances in biosynthesis of natural product drugs within the past decade

Jin FENG, Haixue PAN, Gongli TANG

图6 普拉睾酮和雌四醇在人体内的生物合成路径CYP11A1—细胞色素P450胆固醇侧链裂解酶；CYP17A1—17α-羟化酶/17，20-裂解酶；SULT2A1—磺基转移酶；STS—类固醇硫酸酯酶；AKR1C3—醛酮还原酶

Fig. 6 Biosynthetic pathways of prasterone and estetrol in humans CYP11A1—cytochrome P450 cholesterol side chain cleavage enzyme; CYP17A1—17α-hydroxylase/17,20-lyase; SULT2A1—sulfotransferase; STS—steroid sulfatase; AKR1C3—aldo/keto reductase