近十年天然产物药物的生物合成研究进展

冯金, 潘海学, 唐功利

Research advances in biosynthesis of natural product drugs within the past decade

FENG Jin, PAN Haixue, TANG Gongli

图9 大麻二酚及其他大麻素类似物的生物合成 APT—芳香异戊烯基转移酶；CBDAS—大麻二酚酸合酶；THCAS—四氢大麻酚酸合酶；CBCAS—大麻色烯酸合酶；Δ9-THCA—Δ9-四氢大麻酚酸；CBCA—大麻色烯酸；Δ9-THC—Δ9-四氢大麻酚；CBC—大麻色原烯；PDAL—戊二乙酸内酯；HTAL—己酰三乙酸内酯；GPP—牻牛儿基焦磷酸

Fig. 9 Biosynthesis of CBD and other cannabinoid analogues APT—aromatic prenyltransferase; CBDAS—cannabidiolic acid synthase; THCAS—tetrahydrocannabinolic acid synthase; CBCAS—cannabichromenic acid synthase; Δ9-THCA—Δ9-tetrahydrocannabinolic acid; CBCA—cannabichromenic acid; Δ9-THC—Δ9-tetrahydrocannabinol; CBC—cannabichromene; PDAL—pentyl diacetic lactone; HTAL—hexanoyl triacetic acid lactone; GPP—geranyl pyrophosphate