近十年天然产物药物的生物合成研究进展

冯金, 潘海学, 唐功利

Research advances in biosynthesis of natural product drugs within the past decade

FENG Jin, PAN Haixue, TANG Gongli

图11 CBGA在体外的酶法生物合成 AckA—乙酸激酶；PTA—磷酸乙酰基转移酶；MdcA—丙二酸脱羧酶；MatB—丙二酰辅酶A合成酶；ADK—腺苷酸激酶；AAE3—酰基激活酶；ThiM—羟乙基噻唑激酶；IPK—磷酸激酶；GPPS—牻牛儿基焦磷酸合酶

Fig. 11 Enzymatic biosynthesis of CBGA invitro AckA—acetate kinase; PTA—phosphate acetyltransferase; MdcA—malonate decarboxylase; MatB—malonyl-CoA synthetase; ADK—adenylate kinase; AAE3—acyl-activating enzyme; ThiM—hydroxyethylthiazole kinase; IPK—phosphate kinase; GPPS—geranyl pyrophosphate synthase