近十年天然产物药物的生物合成研究进展

冯金, 潘海学, 唐功利

Research advances in biosynthesis of natural product drugs within the past decade

Jin FENG, Haixue PAN, Gongli TANG

图16 依托泊苷苷元的生物合成途径 （蓝色为新表征的酶）DIR—定向蛋白；PLR—松脂醇-落叶松脂醇还原酶；SDH—开环异落叶松脂酚脱氢酶；CYP719A23/71CU1/71BE54/82D61—细胞色素P450；OMT1/3—O-甲基转移酶；2-ODD—2-酮戊二酸/Fe（Ⅱ）依赖双加氧酶

Fig. 16 Biosynthetic pathway of etoposide aglycone (Newly characterized enzymes are highlighted in blue) DIR—dirigent protein; PLR—pinoresinol-lariciresinol reductase; SDH—secoisolariciresinol dehydrogenase; CYP719A23/71CU1/71BE54/82D61—cytochromes P450; OMT1/3—O-methyltransferases; 2-ODD—2-oxoglutarate/Fe(Ⅱ)-dependent dioxygenase