植物源疫苗研究进展

宋心雨, 潘炜松, 吴泰茹, 潘家豪, 吴川, 李伟展

Research Progress in Plant-Derived Vaccines

SONG Xinyu, PAN Weisong, WU Tairu, PAN Jiahao, WU Chuan, Li Wai chin

图3 P19蛋白作用原理 （侵入植物体的病毒RNA会组装成双链shRNA，被Dicer酶切成21-23bp的siRNA，与RISC组合成siRNA-RISC复合体，并结合至同源的mRNA上使其裂解。而当P19蛋白被表达后，它会组装成二聚体结合siRNA，使siRNA无法结合RISC，从而使沉默过程无法进行。本图由Figdraw绘制。）

Fig. 3 The Mechanism of Action of P19 Protein (The viral RNA that invades the plant body is assembled into double-stranded shRNA, which is cut into 21-23 base pair siRNAs by the Dicer enzyme. These siRNAs form a siRNA-RISC complex and bind to the homologous mRNA, causing it to be cleaved. However, when the P19 protein is expressed, it assembles into a dimer that binds to the siRNA, preventing the siRNA from binding to RISC, and thus the silencing process cannot proceed. By Figdraw.)