固氮合成生物学研究进展

李超, 张焕, 杨军, 王二涛

Research advances in nitrogen fixation synthetic biology

LI Chao, ZHANG Huan, YANG Jun, WANG Ertao

图2 固氮菌中以谷氨酰胺为核心的氮代谢调控通路与增强其固氮能力的策略 （I：删除或调控glnA基因，使游离的NH4+被释放；II：调控nifA的表达，增强NifA对固氮基因簇的激活，增加固氮酶活性）

Fig. 2 The glutamine-core nitrogen metabolism regulatory pathway in diazotrophs and strategies for enhancing nitrogen fixation capacity (I: Delete or regulate the glnA gene to release free NH4+; II: Modulate the expression of NifA to enhance its activation of the nitrogenase gene cluster, thereby increasing nitrogenase activity.)