植物合成生物学与母乳低聚糖生物制造

于文文¹^,²^,³, 吕雪芹¹^,², 李兆丰³, 刘龙¹^,²

Plant synthetic biology and bioproduction of human milk oligosaccharides

YU Wenwen¹^,²^,³, LV Xueqin¹^,², LI Zhaofeng³, LIU Long¹^,²

图1. 典型母乳低聚糖代谢合成途径
（pgi—编码葡萄糖-6-磷酸异构酶基因；zwf—编码6-磷酸葡萄糖脱氢酶基因；pfkA—编码磷酸果糖激酶基因；futC—编码α-1，2-岩藻糖基转移酶基因；futA—编码α-1，3-岩藻糖基转移酶基因；St6—编码α-2，6-唾液酸转移酶基因；St3—编码α-2，3-唾液酸转移酶基因；lgtA—编码β-1，3-N-乙酰氨基葡萄糖氨基转移酶基因；lgtB—编码β-1，4-半乳糖基转移酶基因；wbgO—编码β-1，3-半乳糖转移酶基因；LnbB—编码乳酰-N-二糖苷酶基因；TeSA—编码α-1，2‑岩藻糖基转移酶基因；Bf13FT—编码α-1，3/4-糖基转移酶基因）

Fig. 1. Schematic diagram of metabolic pathways for typical human milk oligosaccharides
(pgi—phosphoglucose isomerase gene; zwf—glucose-6-phosphate dehydrogenase gene; pfkA—phosphofructokinase gene; futC—α-1,2-fucosyltransferase gene; futA—α-1,3-fucosyltransferase gene; St6—α-2,6-sialyltransferase gene; St3—α-2,3-sialyltransferase gene; lgtA—β-1,3-N-acetylglucosaminyltransferease gene; lgtB—β-1,4-galactosyltransferase gene; wbgO—β-1,3-galactosyltransferase gene; LnbB—lacto-N-biosidase gene; TeSA—α-1,2-fucosyltransferase gene; Bf13FT—α-1,3/4-fucosyltransferase gene)