Research progress of yeast mannoprotein Synthetic Biology Journal    DOI: 10.12211/2096-8280.2024-050

Fig. 2 The structural characteristics of yeast mannoprotein
(a, N-glycosylated yeast mannoprotein;b,O-glycosylated yeast mannoprotein)

Extracts from the Article

酵母甘露糖蛋白是一种高度支化的复合碳水化合物，主链为α-1，6甘露糖长链，支链是α-1，2和α-1，3链接的短链，有些侧链通过磷酸酯键进一步分支，可以将其分为三个不同的部分：肽链、核心区（中心区域）和外链，聚合物部分位于其中，如图2所示。聚合区由一个α-（1-6）-糖苷基链组成，其中含有α-（1-2）-和α-（1-3）-糖苷基甘露寡糖作为侧链。肽区含有与氨基酸直接相连的甘露聚糖。

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• Fig. 1  The Function and application of yeast mannoprotein
• Fig. 3  The biosynthetic pathway of yeast mannoprotein(Glu—glucose;G6-P—glucose-6-phosphat;PGM1—Phosphoglucomutase;G1-P—glucose-1-phosphat;UGP1—uridine diphosphate glucose pyrophosphatase;UDP-Glu—uridine diphosphate glucose;PGI1—phosphoglucose isomerase;F6-P—fructose-6-phosphate;M6-P—mannose-6-phosphate;PMI40—mannose phosphate isomerase;SEC53—phosphomannomutase;M1-P—mannose-1-phosphate;PSA1—guanosine diphosphate mannose pyrophosphatase;GDP-Man—guanosine diphosphate mannose;UDP-GlcNAc—uridine diphosphate-N-acetylglucosamine;Dol-P—dolichol phosphate;Alg—glycosyltransferase;OST—oligosaccharides transferase;G-Ⅰ/G-Ⅱ—α- glucosidase;ERMan1—Endoplasmic reticulum mannosidase I;MGAT—mannosyl-glycoprotein-N-acetylglucosaminyltransferase;DPM—dolichol phosphate mannose synthase;PMT—mannosyltransferase)