Single-cell transcriptome combined with biosensing: a new framework for development of molecular diagnostic methods for cervical cancer Synthetic Biology Journal    DOI: 10.12211/2096-8280.2025-084

Fig. 3 Flowchart of a New Research Framework Integrating scRNA-seq and Biosensing

Extracts from the Article

总之，本文所提出的联合先进单细胞转录组以及基于合成生物学原理设计的生物传感技术的宫颈癌分子诊断方法研发新框架（图3），旨在直接回应WHO新指南下宫颈癌防治的临床核心需求。它以单细胞分辨率的标志物发现技术和高灵敏的生物传感技术作为关键的“转化引擎”，目标是开发出能够精准分流HPV阳性人群的新一代分子诊断工具，为实现“筛查、分诊和治疗”新策略提供强大的技术支撑，最终提升宫颈癌精准防控的水平。

Other Images/Table from this Article

• Table 1  Current classification of molecular markers for cervical cancer
• Table 2  Potential Molecular Markers Implicated in Cervical Cancer and Precancerous Lesions.
• Fig. 1  A novel probe set for Fluorescence In Situ Hybridization (FISH) technology
• Fig.2  A nano-robotic biosensor featuring a CRISPR/Cas12a system assembled on gold nanoparticles.