合成生物学 ›› 2021, Vol. 2 ›› Issue (3): 323-334.DOI: 10.12211/2096-8280.2020-086
董一名1, 孙法家1, 武瑞君2, 钱珑1
收稿日期:
2020-11-30
修回日期:
2021-04-04
出版日期:
2021-06-30
发布日期:
2021-07-13
通讯作者:
钱珑
作者简介:
基金资助:
Yiming DONG1, Fajia SUN1, Ruijun WU2, Long QIAN1
Received:
2020-11-30
Revised:
2021-04-04
Online:
2021-06-30
Published:
2021-07-13
Contact:
Long QIAN
摘要:
随着计算机技术的发展,数字化信息存储改变了我们的生活。信息正在以越来越快的速度产生着,但与此伴生的,是如何有效存储数据的问题。诸如磁盘、硬盘、闪存等磁学或光学等传统存储介质已经逐渐不能满足全世界范围内数据存储的需要。DNA分子凭借其稳定性、高存储密度和低维护成本,有望成为实用的新型信息存储介质。本文首先介绍了利用DNA分子进行数据存储的工作流程,继而介绍了DNA数据存储领域的研究历史和研究进展,包括存储方式、读取方式、编码方式等。为实现DNA信息存储,通过信息编码将二进制信息转换成DNA序列信息;DNA合成实现信息写入;最后通过基因测序获取序列信息,进而进行信息解码得到原始信息。而现代分子生物学技术的发展,尤其是DNA合成和测序技术的飞跃,使DNA分子大规模存储人工数据逐渐成为现实。之后,对比了DNA分子相对于传统数据存储介质的优劣,介绍了基于DNA分子的数据存储的风险与挑战,如数据安全性、信息读写的速度和成本等。最后,对DNA数据存储领域未来研究的方向进行了展望,介绍了一些与该领域具备交叉潜力的新兴生物技术领域,如“DNA条形码”“DNA折纸”。
中图分类号:
董一名, 孙法家, 武瑞君, 钱珑. DNA数字信息存储的研究进展[J]. 合成生物学, 2021, 2(3): 323-334.
Yiming DONG, Fajia SUN, Ruijun WU, Long QIAN. Research progress on DNA molecules for digital information storage[J]. Synthetic Biology Journal, 2021, 2(3): 323-334.
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