Synthetic Biology Journal ›› 2024, Vol. 5 ›› Issue (4): 734-753.DOI: 10.12211/2096-8280.2023-100
• Invited Review • Previous Articles Next Articles
Yizhao HAN, Jia GUO, Yue SHAO
Received:
2023-12-01
Revised:
2024-03-04
Online:
2024-09-19
Published:
2024-08-31
Contact:
Yue SHAO
韩宜钊, 郭佳, 邵玥
通讯作者:
邵玥
作者简介:
基金资助:
CLC Number:
Yizhao HAN, Jia GUO, Yue SHAO. Stem cell-based synthetic development: cellular components, embryonic models, and engineering approaches[J]. Synthetic Biology Journal, 2024, 5(4): 734-753.
韩宜钊, 郭佳, 邵玥. 干细胞模拟发育:细胞元件、胚胎模型与工程方法[J]. 合成生物学, 2024, 5(4): 734-753.
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URL: https://synbioj.cip.com.cn/EN/10.12211/2096-8280.2023-100
53 | TAKASHIMA Y, GUO G, LOOS R, et al. Resetting transcription factor control circuitry toward ground-state pluripotency in human[J]. Cell, 2014, 158(6): 1254-1269. |
54 | THEUNISSEN T W, FRIEDLI M, HE Y P, et al. Molecular criteria for defining the naive human pluripotent state[J]. Cell Stem Cell, 2016, 19(4): 502-515. |
55 | BREDENKAMP N, STIRPARO G G, NICHOLS J, et al. The cell-surface marker sushi containing domain 2 facilitates establishment of human naive pluripotent stem cells[J]. Stem Cell Reports, 2019, 12(6): 1212-1222. |
56 | ZIMMERLIN L, PARK T S, HUO J S, et al. Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality[J]. Development, 2016, 143(23): 4368-4380. |
57 | OKAE H, TOH H, SATO T, et al. Derivation of human trophoblast stem cells[J]. Cell Stem Cell, 2018, 22(1): 50-63. e6. |
58 | GUO G, STIRPARO G G, STRAWBRIDGE S E, et al. Human naive epiblast cells possess unrestricted lineage potential[J]. Cell Stem Cell, 2021, 28(6): 1040-1056. e6. |
59 | CASTEL G, MEISTERMANN D, BRETIN B, et al. Induction of human trophoblast stem cells from somatic cells and pluripotent stem cells[J]. Cell Reports, 2020, 33(8): 108419. |
60 | LIU X D, OUYANG J F, ROSSELLO F J, et al. Reprogramming roadmap reveals route to human induced trophoblast stem cells[J]. Nature, 2020, 586(7827): 101-107. |
61 | MAZID M A, WARD C, LUO Z W, et al. Rolling back human pluripotent stem cells to an eight-cell embryo-like stage[J]. Nature, 2022, 605(7909): 315-324. |
62 | MOLÈ M A, WEBERLING A, ZERNICKA-GOETZ M. Comparative analysis of human and mouse development: from zygote to pre-gastrulation[J]. Current Topics in Developmental Biology, 2020, 136: 113-138. |
63 | VAN DEN BRINK S C, VAN OUDENAARDEN A. 3D gastruloids: a novel frontier in stem cell-based in vitro modeling of mammalian gastrulation[J]. Trends in Cell Biology, 2021, 31(9): 747-759. |
64 | SHAHBAZI M N, ZERNICKA-GOETZ M. Deconstructing and reconstructing the mouse and human early embryo[J]. Nature Cell Biology, 2018, 20(8): 878-887. |
65 | KIME C, KIYONARI H, OHTSUKA S, et al. Induced 2C expression and implantation-competent blastocyst-like cysts from primed pluripotent stem cells[J]. Stem Cell Reports, 2019, 13(3): 485-498. |
66 | SOZEN B, COX A L, DE JONGHE J, et al. Self-organization of mouse stem cells into an extended potential blastoid[J]. Developmental Cell, 2019, 51(6): 698-712. e8. |
67 | LI R H, ZHONG C Q, YU Y, et al. Generation of blastocyst-like structures from mouse embryonic and adult cell cultures[J]. Cell, 2019, 179(3): 687-702. e18. |
68 | JANA D, SINGH P, SAILASREE P, et al. Efficient self-organization of blastoids solely from mouse ESCs is facilitated by transient reactivation of 2C gene network[EB/OL]. bioRxiv, 2023: 2023.04.12.536583. (2023-04-13)[2023-12-01]. . |
69 | ZHANG P F, ZHAI X Z, HUANG B Y, et al. Highly efficient generation of blastocyst-like structures from spliceosomes-repressed mouse totipotent blastomere-like cells[J]. Science China Life Sciences, 2023, 66(3): 423-435. |
70 | VAN DEN BRINK S C, BAILLIE-JOHNSON P, BALAYO T, et al. Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells[J]. Development, 2014, 141(22): 4231-4242. |
71 | HARRISON S E, SOZEN B, CHRISTODOULOU N, et al. Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro [J]. Science, 2017, 356(6334): eaal1810. |
72 | SOZEN B, AMADEI G, COX A, et al. Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures[J]. Nature Cell Biology, 2018, 20(8): 979-989. |
73 | ZHANG S P, CHEN T Z, CHEN N X, et al. Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells[J]. Nature Communications, 2019, 10(1): 496. |
74 | GIRGIN M U, BROGUIERE N, HOEHNEL S, et al. Bioengineered embryoids mimic post-implantation development in vitro [J]. Nature Communications, 2021, 12(1): 5140. |
75 | XU P F, BORGES R M, FILLATRE J, et al. Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre[J]. Nature Communications, 2021, 12(1): 3277. |
76 | AMADEI G, LAU K Y C, DE JONGHE J, et al. Inducible stem-cell-derived embryos capture mouse morphogenetic events in vitro [J]. Developmental Cell, 2021, 56(3): 366-382. e9. |
1 | MALL F P. On the frequency of localized anomalies in human embryos and infants at birth[J]. American Journal of Anatomy, 1917, 22(1): 49-72. |
2 | KIM J, KOO B K, KNOBLICH J A. Human organoids: model systems for human biology and medicine[J]. Nature Reviews Molecular Cell Biology, 2020, 21(10): 571-584. |
3 | MA H, MARTI-GUTIERREZ N, PARK S W, et al. Correction of a pathogenic gene mutation in human embryos[J]. Nature, 2017, 548(7668): 413-419. |
4 | DENNIS S J, THOMAS M A, WILLIAMS D B, et al. Embryo morphology score on day 3 is predictive of implantation and live birth rates[J]. Journal of Assisted Reproduction and Genetics, 2006, 23(4): 171-175. |
5 | SHAHBAZI M N, JEDRUSIK A, VUORISTO S, et al. Self-organization of the human embryo in the absence of maternal tissues[J]. Nature Cell Biology, 2016, 18(6): 700-708. |
6 | PERLMAN R L. Mouse models of human disease: an evolutionary perspective[J]. Evolution, Medicine, and Public Health, 2016, 2016(1): 170-176. |
7 | DAVIS N A. Interests and sentience: life before birth: the moral and legal status of embryos and fetuses by bonnie steinbock[J]. The Hastings Center Report, 1994, 24(6): 36-37. |
8 | THOMSON J A, ITSKOVITZ-ELDOR J, SHAPIRO S S, et al. Embryonic stem cell lines derived from human blastocysts[J]. Science, 1998, 282(5391): 1145-1147. |
9 | TAKAHASHI K, TANABE K, OHNUKI M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors[J]. Cell, 2007, 131(5): 861-872. |
10 | LIN F, LI X, SUN S Y, et al. Mechanically enhanced biogenesis of gut spheroids with instability-driven morphomechanics[J]. Nature Communications, 2023, 14(1): 6016. |
11 | CLEVERS H. Modeling development and disease with organoids[J]. Cell, 2016, 165(7): 1586-1597. |
12 | MARTIN G R, EVANS M J. Differentiation of clonal lines of teratocarcinoma cells: formation of embryoid bodies in vitro [J]. Proceedings of the National Academy of Sciences of the United States of America, 1975, 72(4): 1441-1445. |
77 | AMADEI G, HANDFORD C E, QIU C X, et al. Embryo model completes gastrulation to neurulation and organogenesis[J]. Nature, 2022, 610(7930): 143-153. |
78 | TARAZI S, AGUILERA-CASTREJON A, JOUBRAN C, et al. Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs[J]. Cell, 2022, 185(18): 3290-3306. e25. |
79 | LAU K Y C, RUBINSTEIN H, GANTNER C W, et al. Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development[J]. Cell Stem Cell, 2022, 29(10): 1445-1458. e8. |
80 | YU L Q, WEI Y L, DUAN J L, et al. Blastocyst-like structures generated from human pluripotent stem cells[J]. Nature, 2021, 591(7851): 620-626. |
81 | YANAGIDA A, SPINDLOW D, NICHOLS J, et al. Naive stem cell blastocyst model captures human embryo lineage segregation[J]. Cell Stem Cell, 2021, 28(6): 1016-1022. e4. |
82 | LIU X D, TAN J P, SCHRÖDER J, et al. Modelling human blastocysts by reprogramming fibroblasts into iBlastoids[J]. Nature, 2021, 591(7851): 627-632. |
83 | SOZEN B, JORGENSEN V, WEATHERBEE B A T, et al. Reconstructing aspects of human embryogenesis with pluripotent stem cells[J]. Nature Communications, 2021, 12(1): 5550. |
84 | FAN Y, MIN Z Y, ALSOLAMI S, et al. Generation of human blastocyst-like structures from pluripotent stem cells[J]. Cell Discovery, 2021, 7(1): 81. |
85 | YU L Q, LOGSDON D, PINZON-ARTEAGA C A, et al. Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk[J]. Cell Stem Cell, 2023, 30(9): 1246-1261. e9. |
86 | KAGAWA H, JAVALI A, KHOEI H H, et al. Human blastoids model blastocyst development and implantation[J]. Nature, 2022, 601(7894): 600-605. |
87 | DE SANTIS R, RICE E, CROFT G, et al. The emergence of human gastrulation upon in vitro attachment[J]. Stem Cell Reports, 2024, 19(1): 41-53. |
88 | KARVAS R M, ZEMKE J E, ALI S S, et al. 3D-cultured blastoids model human embryogenesis from pre-implantation to early gastrulation stages[J]. Cell Stem Cell, 2023, 30(9): 1148-1165. e7. |
13 | RIVRON N C, FRIAS-ALDEGUER J, VRIJ E J, et al. Blastocyst-like structures generated solely from stem cells[J]. Nature, 2018, 557(7703): 106-111. |
14 | RIVRON N C, MARTINEZ ARIAS A, PERA M F, et al. An ethical framework for human embryology with embryo models[J]. Cell, 2023, 186(17): 3548-3557. |
15 | CLARK A T, BRIVANLOU A, FU J P, et al. Human embryo research, stem cell-derived embryo models and in vitro gametogenesis: considerations leading to the revised ISSCR guidelines[J]. Stem Cell Reports, 2021, 16(6): 1416-1424. |
16 | SHAO Y, FU J P. Engineering multiscale structural orders for high-fidelity embryoids and organoids[J]. Cell Stem Cell, 2022, 29(5): 722-743. |
17 | STEVENS L C, LITTLE C C. Spontaneous testicular teratomas in an inbred strain of mice[J]. Proceedings of the National Academy of Sciences of the United States of America, 1954, 40(11): 1080-1087. |
18 | EVANS M J. The isolation and properties of a clonal tissue culture strain of pluripotent mouse teratoma cells[J]. Journal of Embryology and Experimental Morphology, 1972, 28(1): 163-176. |
19 | EVANS M J, KAUFMAN M H. Establishment in culture of pluripotential cells from mouse embryos[J]. Nature, 1981, 292(5819): 154-156. |
20 | NICHOLS J, SMITH A. Naive and primed pluripotent states[J]. Cell Stem Cell, 2009, 4(6): 487-492. |
21 | HANNA J, MARKOULAKI S, MITALIPOVA M, et al. Metastable pluripotent states in NOD-mouse-derived ESCs[J]. Cell Stem Cell, 2009, 4(6): 513-524. |
22 | TESAR P J, CHENOWETH J G, BROOK F A, et al. New cell lines from mouse epiblast share defining features with human embryonic stem cells[J]. Nature, 2007, 448(7150): 196-199. |
23 | KOJIMA Y, KAUFMAN-FRANCIS K, STUDDERT J B, et al. The transcriptional and functional properties of mouse epiblast stem cells resemble the anterior primitive streak[J]. Cell Stem Cell, 2014, 14(1): 107-120. |
24 | BERNEMANN C, GREBER B, KO K, et al. Distinct developmental ground states of epiblast stem cell lines determine different pluripotency features[J]. Stem Cells, 2011, 29(10): 1496-1503. |
25 | TANAKA S, KUNATH T, HADJANTONAKIS A K, et al. Promotion of trophoblast stem cell proliferation by FGF4[J]. Science, 1998, 282(5396): 2072-2075. |
26 | SEONG J, FRIAS-ALDEGUER J, HOLZMANN V, et al. Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero [J]. Cell Stem Cell, 2022, 29(7): 1102-1118. |
27 | NIAKAN K K, SCHRODE N, CHO L T, et al. Derivation of extraembryonic endoderm stem (XEN) cells from mouse embryos and embryonic stem cells[J]. Nature Protocols, 2013, 8(6): 1028-1041. |
28 | ANDERSON K G V, HAMILTON W B, ROSKE F V, et al. Insulin fine-tunes self-renewal pathways governing naive pluripotency and extra-embryonic endoderm[J]. Nature Cell Biology, 2017, 19(10): 1164-1177. |
29 | OHINATA Y, ENDO T A, SUGISHITA H, et al. Establishment of mouse stem cells that can recapitulate the developmental potential of primitive endoderm[J]. Science, 2022, 375(6580): 574-578. |
30 | YANG Y, LIU B, XU J, et al. Derivation of pluripotent stem cells with in vivo embryonic and extraembryonic potency[J]. Cell, 2017, 169(2): 243-257. e25. |
31 | YANG J, RYAN D J, WANG W, et al. Establishment of mouse expanded potential stem cells[J]. Nature, 2017, 550(7676): 393-397. |
32 | POSFAI E, SCHELL J P, JANISZEWSKI A, et al. Evaluating totipotency using criteria of increasing stringency[J]. Nature Cell Biology, 2021, 23(1): 49-60. |
33 | WANG X X, XIANG Y L, YU Y, et al. Formative pluripotent stem cells show features of epiblast cells poised for gastrulation[J]. Cell Research, 2021, 31(5): 526-541. |
34 | SHEN H, YANG M, LI S Y, et al. Mouse totipotent stem cells captured and maintained through spliceosomal repression[J]. Cell, 2021, 184(11): 2843-2859. e20. |
35 | HU Y Y, YANG Y Y, TAN P C, et al. Induction of mouse totipotent stem cells by a defined chemical cocktail[J]. Nature, 2023, 617(7962): 792-797. |
36 | YANG M Z, YU H W, YU X, et al. Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells[J]. Cell Stem Cell, 2022, 29(3): 400-418. e13. |
89 | SHAO Y, TANIGUCHI K, GURDZIEL K, et al. Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche[J]. Nature Materials, 2017, 16(4): 419-425. |
90 | SHAO Y, TANIGUCHI K, TOWNSHEND R F, et al. A pluripotent stem cell-based model for post-implantation human amniotic sac development[J]. Nature Communications, 2017, 8(1): 208. |
91 | ZHENG Y, XUE X F, SHAO Y, et al. Controlled modelling of human epiblast and amnion development using stem cells[J]. Nature, 2019, 573(7774): 421-425. |
92 | ROSTOVSKAYA M, ANDREWS S, REIK W, et al. Amniogenesis occurs in two independent waves in primates[J]. Cell Stem Cell, 2022, 29(5): 744-759. e6. |
93 | WARMFLASH A, SORRE B, ETOC F, et al. A method to recapitulate early embryonic spatial patterning in human embryonic stem cells[J]. Nature Methods, 2014, 11(8): 847-854. |
94 | MORIS N, ANLAS K, VAN DEN BRINK S C, et al. An in vitro model of early anteroposterior organization during human development[J]. Nature, 2020, 582(7812): 410-415. |
95 | SIMUNOVIC M, SIGGIA E D, BRIVANLOU A H. In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells[J]. Cell Stem Cell, 2022, 29(6): 962-972. |
96 | AI Z Y, NIU B H, YIN Y, et al. Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids[J]. Cell Research, 2023, 33(9): 661-678. |
97 | XIANG L F, YIN Y, ZHENG Y, et al. A developmental landscape of 3D-cultured human pre-gastrulation embryos[J]. Nature, 2020, 577(7791): 537-542. |
98 | WEATHERBEE B A T, GANTNER C W, IWAMOTO-STOHL L K, et al. Pluripotent stem cell-derived model of the post-implantation human embryo[J]. Nature, 2023, 622(7983): 584-593. |
99 | PEDROZA M, GASSALOGLU S I, DIAS N, et al. Self-patterning of human stem cells into post-implantation lineages[J]. Nature, 2023, 622: 574-583. |
100 | YING Q L, WRAY J, NICHOLS J, et al. The ground state of embryonic stem cell self-renewal[J]. Nature, 2008, 453(7194): 519-523. |
37 | XU Y X, ZHAO J R, REN Y X, et al. Derivation of totipotent-like stem cells with blastocyst-like structure forming potential[J]. Cell Research, 2022, 32(6): 513-529. |
38 | WU J, GREELY H T, JAENISCH R, et al. Stem cells and interspecies chimaeras[J]. Nature, 2016, 540(7631): 51-59. |
39 | GUO H S, ZHU P, YAN L Y, et al. The DNA methylation landscape of human early embryos[J]. Nature, 2014, 511(7511): 606-610. |
40 | YAN L Y, YANG M Y, GUO H S, et al. Single-cell RNA-seq profiling of human preimplantation embryos and embryonic stem cells[J]. Nature Structural & Molecular Biology, 2013, 20(9): 1131-1139. |
41 | O′LEARY T, HEINDRYCKX B, LIERMAN S, et al. Tracking the progression of the human inner cell mass during embryonic stem cell derivation[J]. Nature Biotechnology, 2012, 30(3): 278-282. |
42 | CHEN G K, GULBRANSON D R, HOU Z G, et al. Chemically defined conditions for human iPSC derivation and culture[J]. Nature Methods, 2011, 8(5): 424-429. |
43 | LUDWIG T E, LEVENSTEIN M E, JONES J M, et al. Derivation of human embryonic stem cells in defined conditions[J]. Nature Biotechnology, 2006, 24: 185-187. |
44 | OKUBO T, RIVRON N, KABATA M, et al. Hypoblast from human pluripotent stem cells regulates epiblast development[J]. Nature, 2024, 626(7998): 357-366. |
45 | GUO G, VON MEYENN F, SANTOS F, et al. Naive pluripotent stem cells derived directly from isolated cells of the human inner cell mass[J]. Stem Cell Reports, 2016, 6(4): 437-446. |
46 | LIU X D, NEFZGER C M, ROSSELLO F J, et al. Comprehensive characterization of distinct states of human naive pluripotency generated by reprogramming[J]. Nature Methods, 2017, 14(11): 1055-1062. |
47 | GIULITTI S, PELLEGRINI M, ZORZAN I, et al. Direct generation of human naive induced pluripotent stem cells from somatic cells in microfluidics[J]. Nature Cell Biology, 2019, 21(2): 275-286. |
48 | KILENS S, MEISTERMANN D, MORENO D, et al. Parallel derivation of isogenic human primed and naive induced pluripotent stem cells[J]. Nature Communications, 2018, 9(1): 360. |
49 | BAYERL J, AYYASH M, SHANI T, et al. Principles of signaling pathway modulation for enhancing human naive pluripotency induction[J]. Cell Stem Cell, 2021, 28(9): 1549-1565. e12. |
50 | THEUNISSEN T W, POWELL B E, WANG H Y, et al. Systematic identification of culture conditions for induction and maintenance of naive human pluripotency[J]. Cell Stem Cell, 2014, 15(4): 471-487. |
51 | CHAN Y S, GÖKE J, NG J H, et al. Induction of a human pluripotent state with distinct regulatory circuitry that resembles preimplantation epiblast[J]. Cell Stem Cell, 2013, 13(6): 663-675. |
52 | GAFNI O, WEINBERGER L, MANSOUR A A, et al. Derivation of novel human ground state naive pluripotent stem cells[J]. Nature, 2013, 504(7479): 282-286. |
101 | LIU L Z, OURA S, MARKHAM Z, et al. Modeling post-implantation stages of human development into early organogenesis with stem-cell-derived peri-gastruloids[J]. Cell, 2023, 186(18): 3776-3792. |
102 | OLDAK B, WILDSCHUTZ E, BONDARENKO V, et al. Complete human day 14 post-implantation embryo models from naive ES cells[J]. Nature, 2023, 622(7983): 562-573. |
103 | KARSENTI E. Self-organization in cell biology: a brief history[J]. Nature Reviews Molecular Cell Biology, 2008, 9(3): 255-262. |
104 | CHEN Q, SHI J C, TAO Y, et al. Tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo[J]. Nature Communications, 2018, 9(1): 1819. |
105 | IMUTA Y, KOYAMA H, SHI D B, et al. Mechanical control of notochord morphogenesis by extra-embryonic tissues in mouse embryos[J]. Mechanisms of Development, 2014, 132: 44-58. |
106 | CAMPÀS O. A toolbox to explore the mechanics of living embryonic tissues[J]. Seminars in Cell & Developmental Biology, 2016, 55: 119-130. |
107 | CHAN C J, COSTANZO M, RUIZ-HERRERO T, et al. Hydraulic control of mammalian embryo size and cell fate[J]. Nature, 2019, 571(7763): 112-116. |
108 | HIRAMATSU R, MATSUOKA T, KIMURA-YOSHIDA C, et al. External mechanical cues trigger the establishment of the anterior-posterior axis in early mouse embryos[J]. Developmental Cell, 2013, 27(2): 131-144. |
109 | SAMAL P, MAURER P, VAN BLITTERSWIJK C, et al. A new microengineered platform for 4D tracking of single cells in a stem-cell-based in vitro morphogenesis model[J]. Advanced Materials, 2020, 32(24): e1907966. |
110 | CHUNG K, KIM Y, KANODIA J S, et al. A microfluidic array for large-scale ordering and orientation of embryos[J]. Nature Methods, 2011, 8(2): 171-176. |
111 | SONNEN K F, LAUSCHKE V M, URAJI J, et al. Modulation of phase shift between Wnt and Notch signaling oscillations controls mesoderm segmentation[J]. Cell, 2018, 172(5): 1079-1090. e12. |
112 | GOVINDASAMY N, LONG H Y, JEONG H W, et al. 3D biomimetic platform reveals the first interactions of the embryo and the maternal blood vessels[J]. Developmental Cell, 2021, 56(23): 3276-3287. |
113 | SAMAL P, VAN BLITTERSWIJK C, TRUCKENMÜLLER R, et al. Grow with the flow: when morphogenesis meets microfluidics[J]. Advanced Materials, 2019, 31(17): e1805764. |
114 | REPINA N A, JOHNSON H J, BAO X P, et al. Optogenetic control of Wnt signaling models cell-intrinsic embryogenic patterning using 2D human pluripotent stem cell culture[J]. Development, 2023, 150(14): dev201386. |
115 | IZQUIERDO E, QUINKLER T, DE RENZIS S. Guided morphogenesis through optogenetic activation of Rho signalling during early Drosophila embryogenesis [J]. Nature Communications, 2018, 9(1): 2366. |
116 | VEENVLIET J V, BOLONDI A, KRETZMER H, et al. Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites[J]. Science, 2020, 370(6522): eaba4937. |
117 | BONDARENKO V, NIKOLAEV M, KROMM D, et al. Embryo-uterine interaction coordinates mouse embryogenesis during implantation[J]. The EMBO Journal, 2023, 42(17): e113280. |
118 | AGUILERA-CASTREJON A, OLDAK B, SHANI T, et al. Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis[J]. Nature, 2021, 593(7857): 119-124. |
119 | PINZÓN-ARTEAGA C A, WANG Y J, WEI Y L, et al. Bovine blastocyst-like structures derived from stem cell cultures[J]. Cell Stem Cell, 2023, 30(5): 611-616. e7. |
120 | NIETHAMMER M, BURGDORF T, WISTORF E, et al. In vitro models of human development and their potential application in developmental toxicity testing[J]. Development, 2022, 149(20): dev200933. |
121 | DE BAKKER B S, DE JONG K H, HAGOORT J, et al. An interactive three-dimensional digital atlas and quantitative database of human development[J]. Science, 2016, 354(6315): aag0053. |
122 | HERTIG A T, ROCK J, ADAMS E C. A description of 34 human ova within the first 17 days of development[J]. The American Journal of Anatomy, 1956, 98(3): 435-493. |
123 | FUJIMOTO T. Nishimura's collection of human embryos and related publications[J]. Congenital Anomalies, 2001, 41(1): 67-71. |
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