Research on market access and regulation of global bio-manufactured feed protein materials and additives Synthetic Biology Journal    DOI: 10.12211/2096-8280.2025-060

Table 1 Early global industrialization of single-cell protein technologies

Extracts from the Article

生物制造技术（合成生物学、精密发酵等）为饲料蛋白提供了可持续替代方案，以微藻、细菌、酵母等来源的单细胞蛋白（Single Cell Protein， SCP）以及丝状真菌蛋白是目前饲料蛋白最优的替代品［12-14］。微生物蛋白的生产早在20世纪60年代就已经开始发展，如表1所示，英国石油公司（British Petroleum）的研究人员开发了一项 “利用酵母从石油副产物中生产蛋白质”的新技术［15， 16］。20世纪70年代第一个商业化的微生物饲料产品Pruteen是英国帝国化学工业公司（Imperial Chemical Industries， ICI）以甲醇作原料用甲基营养菌生产的SCP，主要用作家禽和牛的饲料［2， 17］。微生物蛋白不仅蛋白含量高，营养丰富，而且还可以利用农业废弃物、工业废水等作为原料，既实现了废弃物的资源化利用，又缓解了饲料蛋白的短缺问题［18-21］。

Other Images/Table from this Article

• Table 2  EFSA’s classification of genetically modified microorganisms with typical cases for feeding
• Table 3  EFSA’s key regulations and guidance documents on feed and additive access for GMMs
• Fig.1  The difference between produced from GMO and produced with GMO on market access and regulation.
• Table 4  Protein materials or additives approved for feeding in the EU
• Table 5  Typical cases of protein-related feeding additives in the United States
• Fig.2  Regulatory framework for feed and feed additives in Japan
• Fig. 3  The approval process for genetically modified feed in Japan
• Table 6  List of protein raw materials or additives for feeding in Japan
• Table 7  Bio-manufactured feed raw materials or additives approved in the period 2012-2025
• Table 8  Basic requirements for strain identification and safety evaluation
• Table 9  List of approved agricultural GMO safety certificates (Feed Applications) 2023-2024