合成生物学 ›› 2023, Vol. 4 ›› Issue (6): 1300-1320.DOI: 10.12211/2096-8280.2022-052
• 研究论文 • 上一篇
郑庆祥
收稿日期:
2022-09-23
修回日期:
2022-11-16
出版日期:
2023-12-31
发布日期:
2024-01-19
通讯作者:
郑庆祥
作者简介:
基金资助:
ZHENG Qingxiang
Received:
2022-09-23
Revised:
2022-11-16
Online:
2023-12-31
Published:
2024-01-19
Contact:
ZHENG Qingxiang
摘要:
本研究解析了Shewanella sp. MR-4在厌氧条件下以Fe3+、延胡索酸、硝酸和二甲基亚砜(DMSO)为末端电子受体时代谢通量分布,发现在各种不同末端电子受体条件下细胞内代谢通量分布发生显著改变。与延胡索酸相比,在Fe3+和硝酸为电子受体条件下,乙酸生成速率明显降低,而三羧酸循环代谢通量增加。同时,三羧酸循环回补反应存在显著差异:在延胡索酸为电子受体条件下,磷酸烯醇式丙酮酸羧化酶反应是唯一回补反应,而在Fe3+和硝酸条件下苹果酸酶催化成为唯一回补反应。本研究在代谢通量分析基础上定量解析了还原力NADH合成和消耗,分析了电子流向变化,发现在不同末端电子受体条件下,NADH产生途径和反应发生明显变化。研究结果为希瓦氏菌代谢工程改造提供了一定理论依据。
中图分类号:
郑庆祥. 希瓦氏菌Shewanella sp. MR-4在不同末端电子受体条件下的代谢通量分析[J]. 合成生物学, 2023, 4(6): 1300-1320.
ZHENG Qingxiang. Metabolic flux analysis of Shewanella sp. MR-4 with different terminal electron receptors[J]. Synthetic Biology Journal, 2023, 4(6): 1300-1320.
碱性溶液 Basic solution | ||
---|---|---|
成分 Component | 浓度/(mmol/L) Concentration/(mmol/L) | |
PIPES | 30 | |
NH4Cl | 28.04 | |
KCl | 1.34 | |
NaH2PO4·2H2O | 4.35 | |
NaCl | 30 | |
Na2SO4 | 0.7 | |
矿物溶液 Mineral solution | ||
成分 Component | 浓度/(µmol/L) Concentration/ (µmol/L) | |
C6H9NO6 | 78.49 | |
MgSO4·7H2O | 121.71 | |
MnSO4·H2O | 29.58 | |
FeSO4·7H2O | 3.6 | |
CaCl2·2H2O | 6.8 | |
CoCl2·6H2O | 4.2 | |
ZnCl2 | 9.54 | |
CuSO4·5H2O | 0.4 | |
AlK(SO4)2·12H2O | 0.21 | |
H3BO3 | 1.62 | |
Na2MoO4·2H2O | 1.03 | |
NiCl2·6H2O | 1.01 | |
Na2WO4·2H2O | 0.76 | |
维生素溶液 Vitamin solution | ||
成分 Component | 浓度/(µmol/L) Concentration/(µmol/L) | |
D-生物素 | D-biotin | 81.87 |
叶酸 | folic acid | 45.34 |
盐酸吡哆醇 | pyridoxine HCl | 486.38 |
核黄素 | riboflavin | 132.84 |
盐酸硫胺素 | thiamine HCl | 140.73 |
烟碱酸 | nicotinic acid | 406.17 |
D-泛酸,半钙盐 | D-pantothenic acid, hemi calcium salt | 209.82 |
维生素B12 | VB12 | 7.4 |
对氨基苯甲酸 | p-amino benzoic acid | 364.62 |
硫辛酸 | thioctic acid | 242.37 |
氯化胆碱 | choline chloride | 14.3246 |
表1 修改型M1基本培养基
Table 1 Modified M1 minimal medium
碱性溶液 Basic solution | ||
---|---|---|
成分 Component | 浓度/(mmol/L) Concentration/(mmol/L) | |
PIPES | 30 | |
NH4Cl | 28.04 | |
KCl | 1.34 | |
NaH2PO4·2H2O | 4.35 | |
NaCl | 30 | |
Na2SO4 | 0.7 | |
矿物溶液 Mineral solution | ||
成分 Component | 浓度/(µmol/L) Concentration/ (µmol/L) | |
C6H9NO6 | 78.49 | |
MgSO4·7H2O | 121.71 | |
MnSO4·H2O | 29.58 | |
FeSO4·7H2O | 3.6 | |
CaCl2·2H2O | 6.8 | |
CoCl2·6H2O | 4.2 | |
ZnCl2 | 9.54 | |
CuSO4·5H2O | 0.4 | |
AlK(SO4)2·12H2O | 0.21 | |
H3BO3 | 1.62 | |
Na2MoO4·2H2O | 1.03 | |
NiCl2·6H2O | 1.01 | |
Na2WO4·2H2O | 0.76 | |
维生素溶液 Vitamin solution | ||
成分 Component | 浓度/(µmol/L) Concentration/(µmol/L) | |
D-生物素 | D-biotin | 81.87 |
叶酸 | folic acid | 45.34 |
盐酸吡哆醇 | pyridoxine HCl | 486.38 |
核黄素 | riboflavin | 132.84 |
盐酸硫胺素 | thiamine HCl | 140.73 |
烟碱酸 | nicotinic acid | 406.17 |
D-泛酸,半钙盐 | D-pantothenic acid, hemi calcium salt | 209.82 |
维生素B12 | VB12 | 7.4 |
对氨基苯甲酸 | p-amino benzoic acid | 364.62 |
硫辛酸 | thioctic acid | 242.37 |
氯化胆碱 | choline chloride | 14.3246 |
菌种 | 乳酸盐(lactate) 氧气(oxygen) 有氧(aerobic) | 乳酸盐(lactate) 延胡索酸(fumarate) 厌氧(anaerobic) | 葡萄糖(glucose) 延胡索酸(fumarate) 厌氧(anaerobic) | 葡萄糖(glucose) 次氮基三乙酸铁(Fe-NTA) 厌氧(anaerobic) |
---|---|---|---|---|
Shewanella putrefaciens CN-32 | + | + | + | - |
Shewanella loihica PV-4 | + | + | + | + |
Shewanella sp. MR-4 | + | + | + | + |
Shewanella amazonensis SB2B | + | + | + | + |
Shewanella sp. W3-18-1 | + | + | + | - |
Shewanella baltica OS155 | + | + | + | + |
Shewanella denitrificans OS217 | + | + | - | - |
Shewanella oneidensis MR-1 | + | + | - | - |
Shewanella sp. MR-7 | + | + | - | + |
Shewanella sp. ANA-3 | + | + | + | + |
Shewanella pealeana ANG-SQ1 | + | - | - | - |
Shewanella frigidimarina NCIMB400 | + | + | - | - |
表2 希瓦氏菌12株菌株生长表型
Table 2 Growth phenotype of 12 Shewanella sp. strains
菌种 | 乳酸盐(lactate) 氧气(oxygen) 有氧(aerobic) | 乳酸盐(lactate) 延胡索酸(fumarate) 厌氧(anaerobic) | 葡萄糖(glucose) 延胡索酸(fumarate) 厌氧(anaerobic) | 葡萄糖(glucose) 次氮基三乙酸铁(Fe-NTA) 厌氧(anaerobic) |
---|---|---|---|---|
Shewanella putrefaciens CN-32 | + | + | + | - |
Shewanella loihica PV-4 | + | + | + | + |
Shewanella sp. MR-4 | + | + | + | + |
Shewanella amazonensis SB2B | + | + | + | + |
Shewanella sp. W3-18-1 | + | + | + | - |
Shewanella baltica OS155 | + | + | + | + |
Shewanella denitrificans OS217 | + | + | - | - |
Shewanella oneidensis MR-1 | + | + | - | - |
Shewanella sp. MR-7 | + | + | - | + |
Shewanella sp. ANA-3 | + | + | + | + |
Shewanella pealeana ANG-SQ1 | + | - | - | - |
Shewanella frigidimarina NCIMB400 | + | + | - | - |
电子受体 (Electron acceptor) | 用于生物质合成的 葡萄糖的比例 (Percentage of glucose for biomass synthesis) | 比率/[mmol/(gCDW·h)] Specific rate/[mmol/(gCDW·h)] | 碳平衡 (Carbon balance) | |||
---|---|---|---|---|---|---|
葡萄糖摄取 (Glucose uptake) | 醋酸盐分泌 (Acetate secretion) | EPS形成 (EPS formation) | CO2净生成 (Net CO2 formation) | |||
硝酸盐(Nitrate) | 12.2% ± 0.5% | 8.27 ± 0.24 | 4.19 ± 0.21 | 2.49 ± 0.11 | 17.47 ± 0.94 | 94.5% |
Fe | 5.1% ± 0.2% | 4.86 ± 0.20 | 3.74 ± 0.19 | 1.28 ± 0.04 | 10.72 ± 0.35 | 93.9% |
延胡索酸(Fumarate) | 11.7%± 0.4% | 5.04 ± 0.17 | 8.33 ± 0.54 | 0.31 ± 0.01 | 7.23 ± 0.38 | 96.8% |
DMSO | 5.9% ± 0.2% | 5.38 ± 0.15 | 9.48 ± 0.47 | 0.47 ± 0.02 | 6.92 ± 0.21 | 94.9% |
表3 Shewanella sp. MR-4在各种末端电子受体上厌氧生长参数
Table 3 Anaerobic growth parameters of Shewanella sp. MR-4 exposed to various terminal electron acceptors
电子受体 (Electron acceptor) | 用于生物质合成的 葡萄糖的比例 (Percentage of glucose for biomass synthesis) | 比率/[mmol/(gCDW·h)] Specific rate/[mmol/(gCDW·h)] | 碳平衡 (Carbon balance) | |||
---|---|---|---|---|---|---|
葡萄糖摄取 (Glucose uptake) | 醋酸盐分泌 (Acetate secretion) | EPS形成 (EPS formation) | CO2净生成 (Net CO2 formation) | |||
硝酸盐(Nitrate) | 12.2% ± 0.5% | 8.27 ± 0.24 | 4.19 ± 0.21 | 2.49 ± 0.11 | 17.47 ± 0.94 | 94.5% |
Fe | 5.1% ± 0.2% | 4.86 ± 0.20 | 3.74 ± 0.19 | 1.28 ± 0.04 | 10.72 ± 0.35 | 93.9% |
延胡索酸(Fumarate) | 11.7%± 0.4% | 5.04 ± 0.17 | 8.33 ± 0.54 | 0.31 ± 0.01 | 7.23 ± 0.38 | 96.8% |
DMSO | 5.9% ± 0.2% | 5.38 ± 0.15 | 9.48 ± 0.47 | 0.47 ± 0.02 | 6.92 ± 0.21 | 94.9% |
反应编号 (Reaction No.) | 酶 (Enzyme) | 基因 (Gene) | 反应化学计量学 (Stoichiometric reaction) | 碳原子转换 (Carbon atom transition) |
---|---|---|---|---|
v1 | glucokinase | Shewmr4_1763 | Glucose => G6P | #ABCDEF => #ABCDEF |
v2 | glucose-6-phosphate 1-dehydrogenase | Shewmr4_2046 | G6P => 6PG | #ABCDEF => #ABCDEF |
6-phosphogluconolactonase | Shewmr4_2045 | |||
v3 | phosphogluconate dehydratase | Shewmr4_2044 | 6PG => KDPG | #ABCDEF => #ABCDEF |
2-keto-3-deoxy-phosphogluconate aldolase | Shewmr4_2043 | KDPG => GAP + PYR | #ABCDEF => #DEF + #ABC | |
v4 | glucose-6-phosphate isomerase | Shewmr4_2968 | G6P <=> F6P | #ABCDEF <=> #ABCDEF |
v5 | 6-phosphogluconate dehydrogenase | Shewmr4_1609 | 6PG => P5P + CO2 | #ABCDEF => #BCDEF + #A |
v6 | transketolase | Shewmr4_0773 | S7P + GAP <=> P5P + P5P | #abcdefg + #ABC <=> #cdefg + #abABC |
v7 | transaldolase | Shewmr4_2967 | S7P + GAP <=> F6P + E4P | #abcdefg + #ABC <=> #abcABC + #defg |
v8 | transketolase | Shewmr4_0773 | F6P + GAP <=> P5P + E4P | #abcdef + #ABC <=> #abABC+ #cdef |
v9 | glyceraldehy-3-phosphate dehydrogenase | Shewmr4_0536 | GAP <=> 1,3-BPG | #ABC <=> #ABC |
phosphoglycerate kinase | Shewmr4_0775 | 1,3-BPG <=> 3PG | #ABC <=> #ABC | |
phosphoglyceromutase | Shewmr4_0045 | 3PG <=> 2PG | #ABC <=> #ABC | |
enolase | Shewmr4_1115 | 2PG <=> PEP | #ABC <=> #ABC | |
v10 | pyruvate kinase | Shewmr4_2048 | PEP => PYR | #ABC => #ABC |
v11 | phosphoenolpyruvate carboxylase | Shewmr4_3710 | PEP + CO2 => OAA | #ABC + #D => #ABCD |
v12 | phosphoenolpyruvate carboxykinase | Shewmr4_0152 | OAA => PEP + CO2 | #ABCD => #ABC + #D |
v13 | NAD-dependent malic enzyme | Shewmr4_3188 | MAL <=> PYR + CO2 | #ABCD <=> #ABC + #D |
NADP-dependent malic enzyme | Shewmr4_3492 | |||
v14 | pyruvate dehydrogenase subunit E1 | Shewmr4_0428 | PYR =>ACoA + CO2 | #ABC=>#BC + #A |
pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase | Shewmr4_0429 | |||
dihydrolipoamide dehydrogenase | Shewmr4_0430 | |||
v15 | type Ⅱ citrate synthase | Shewmr4_1630 | ACoA + OAA => ICT | #abcd+#AB => #dcbaBA |
bifunctional aconitate hydratase | Shewmr4_0437 | |||
v16 | isocitrate dehydrogenase, NADP-dependent | Shewmr4_1606 | ICT => AKG + CO2 | #abcdef => #abcef + #d |
isocitrate dehydrogenase [NAD] | Shewmr4_2720 | |||
v17 | 2-oxoglutarate dehydrogenase E1 component | Shewmr4_1635 | AKG => FUM + CO2 | #ABCDE => #BCDE+#A |
dihydrolipoamide dehydrogenase | Shewmr4_0430 | |||
2-oxoglutarate dehydrogenase E2 component | Shewmr4_1636 | |||
succinyl-CoA synthetase subunit beta | Shewmr4_1637 | |||
fumarate reductase cytochrome b-556 subunit | Shewmr4_0402 | |||
fumarase | Shewmr4_2124 | FUM <=> MAL | #ABCD <=> #ABCD #ABCD => #DCBA | |
v18 | malate dehydrogenase | Shewmr4_3339 | MAL <=> OAA | #ABCD <=> #ABCD |
v19 | biomass synthesis | |||
v20 | acetate formation | ACoA => Ace | ||
v21 | EPS synthesis | G6P => EPS |
表4 Shewanella sp. MR-4中心代谢网络反应化学计量学和相应碳原子转换
Table 4 Central metabolic network in Shewanella sp. MR-4 with the stoichiometric reactions and the corresponding carbon atom transitions
反应编号 (Reaction No.) | 酶 (Enzyme) | 基因 (Gene) | 反应化学计量学 (Stoichiometric reaction) | 碳原子转换 (Carbon atom transition) |
---|---|---|---|---|
v1 | glucokinase | Shewmr4_1763 | Glucose => G6P | #ABCDEF => #ABCDEF |
v2 | glucose-6-phosphate 1-dehydrogenase | Shewmr4_2046 | G6P => 6PG | #ABCDEF => #ABCDEF |
6-phosphogluconolactonase | Shewmr4_2045 | |||
v3 | phosphogluconate dehydratase | Shewmr4_2044 | 6PG => KDPG | #ABCDEF => #ABCDEF |
2-keto-3-deoxy-phosphogluconate aldolase | Shewmr4_2043 | KDPG => GAP + PYR | #ABCDEF => #DEF + #ABC | |
v4 | glucose-6-phosphate isomerase | Shewmr4_2968 | G6P <=> F6P | #ABCDEF <=> #ABCDEF |
v5 | 6-phosphogluconate dehydrogenase | Shewmr4_1609 | 6PG => P5P + CO2 | #ABCDEF => #BCDEF + #A |
v6 | transketolase | Shewmr4_0773 | S7P + GAP <=> P5P + P5P | #abcdefg + #ABC <=> #cdefg + #abABC |
v7 | transaldolase | Shewmr4_2967 | S7P + GAP <=> F6P + E4P | #abcdefg + #ABC <=> #abcABC + #defg |
v8 | transketolase | Shewmr4_0773 | F6P + GAP <=> P5P + E4P | #abcdef + #ABC <=> #abABC+ #cdef |
v9 | glyceraldehy-3-phosphate dehydrogenase | Shewmr4_0536 | GAP <=> 1,3-BPG | #ABC <=> #ABC |
phosphoglycerate kinase | Shewmr4_0775 | 1,3-BPG <=> 3PG | #ABC <=> #ABC | |
phosphoglyceromutase | Shewmr4_0045 | 3PG <=> 2PG | #ABC <=> #ABC | |
enolase | Shewmr4_1115 | 2PG <=> PEP | #ABC <=> #ABC | |
v10 | pyruvate kinase | Shewmr4_2048 | PEP => PYR | #ABC => #ABC |
v11 | phosphoenolpyruvate carboxylase | Shewmr4_3710 | PEP + CO2 => OAA | #ABC + #D => #ABCD |
v12 | phosphoenolpyruvate carboxykinase | Shewmr4_0152 | OAA => PEP + CO2 | #ABCD => #ABC + #D |
v13 | NAD-dependent malic enzyme | Shewmr4_3188 | MAL <=> PYR + CO2 | #ABCD <=> #ABC + #D |
NADP-dependent malic enzyme | Shewmr4_3492 | |||
v14 | pyruvate dehydrogenase subunit E1 | Shewmr4_0428 | PYR =>ACoA + CO2 | #ABC=>#BC + #A |
pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase | Shewmr4_0429 | |||
dihydrolipoamide dehydrogenase | Shewmr4_0430 | |||
v15 | type Ⅱ citrate synthase | Shewmr4_1630 | ACoA + OAA => ICT | #abcd+#AB => #dcbaBA |
bifunctional aconitate hydratase | Shewmr4_0437 | |||
v16 | isocitrate dehydrogenase, NADP-dependent | Shewmr4_1606 | ICT => AKG + CO2 | #abcdef => #abcef + #d |
isocitrate dehydrogenase [NAD] | Shewmr4_2720 | |||
v17 | 2-oxoglutarate dehydrogenase E1 component | Shewmr4_1635 | AKG => FUM + CO2 | #ABCDE => #BCDE+#A |
dihydrolipoamide dehydrogenase | Shewmr4_0430 | |||
2-oxoglutarate dehydrogenase E2 component | Shewmr4_1636 | |||
succinyl-CoA synthetase subunit beta | Shewmr4_1637 | |||
fumarate reductase cytochrome b-556 subunit | Shewmr4_0402 | |||
fumarase | Shewmr4_2124 | FUM <=> MAL | #ABCD <=> #ABCD #ABCD => #DCBA | |
v18 | malate dehydrogenase | Shewmr4_3339 | MAL <=> OAA | #ABCD <=> #ABCD |
v19 | biomass synthesis | |||
v20 | acetate formation | ACoA => Ace | ||
v21 | EPS synthesis | G6P => EPS |
图1 Shewanella sp. MR-4中心碳代谢生物反应网络(虚线箭头表示本研究中鉴定为无活性反应或途径。双向箭头表示推测为可逆反应)
Fig. 1 Bioreaction network of central carbon metabolism of Shewanella sp. MR-4(Dashed arrows indicate reactions or pathways identified to be inactive in this study. Double-headed arrows indicate reactions assumed to be reversible)
代谢物 (Metabolite) | Shewanella sp. MR-4在总池中的比例 (Percentage of total pool in Shewanella sp. MR-4) | |||
---|---|---|---|---|
硝酸盐(nitrate) | Fe | DMSO | 延胡索酸(fumarate) | |
PEP from PP pathway (ub) | 2.2 % | 3.2 % | 6.7 % | 1.9 % |
PEP from OAA (ub) | 2.7 % | 2.7 % | 6.7 % | 0.0 % |
PYR from OAA (ub) | 7.2 % | 11.8 % | 29.8 % | 0.5 % |
PYR from OAA (lb) | 3.4 % | 9.7 % | 11.7 % | 0.5 % |
OAA from PEP | 0.0 % | 0.0 % | 80.7 % | 93.1 % |
MAL from PYR | 33.5 % | 84.3 % | 0.0 % | 0.0 % |
OAA from glyoxylate shunt | 0.0 % | 0.0 % | 0.0 % | 0.0 % |
Ser from Gly | 0.0 % | 28.6 % | 18.6 % | 23.0 % |
Gly from Ser | 84.2 % | 77.0 % | 100.0 % | 86.1 % |
表5 通过流比例分析确定中间代谢物来源
Table 5 Origins of metabolic intermediates determined by flux ratio analysis
代谢物 (Metabolite) | Shewanella sp. MR-4在总池中的比例 (Percentage of total pool in Shewanella sp. MR-4) | |||
---|---|---|---|---|
硝酸盐(nitrate) | Fe | DMSO | 延胡索酸(fumarate) | |
PEP from PP pathway (ub) | 2.2 % | 3.2 % | 6.7 % | 1.9 % |
PEP from OAA (ub) | 2.7 % | 2.7 % | 6.7 % | 0.0 % |
PYR from OAA (ub) | 7.2 % | 11.8 % | 29.8 % | 0.5 % |
PYR from OAA (lb) | 3.4 % | 9.7 % | 11.7 % | 0.5 % |
OAA from PEP | 0.0 % | 0.0 % | 80.7 % | 93.1 % |
MAL from PYR | 33.5 % | 84.3 % | 0.0 % | 0.0 % |
OAA from glyoxylate shunt | 0.0 % | 0.0 % | 0.0 % | 0.0 % |
Ser from Gly | 0.0 % | 28.6 % | 18.6 % | 23.0 % |
Gly from Ser | 84.2 % | 77.0 % | 100.0 % | 86.1 % |
图2 Shewanella sp. MR-4在以硝酸、Fe3+(a)和延胡索酸、二甲基亚砜(b)作为末端电子受体时胞内代谢通量分布[代谢反应旁边数字为该反应净通量(net flux),是以底物葡萄糖比摄取速率进行归一化后数值](a)上,硝酸;下,Fe3+。(b)上,延胡索酸;下,二甲基亚砜
Fig. 2 Intracellular metabolic flux distributions in Shewanella sp. MR-4 with (a) nitrate, Fe3+, (b) fumarate or DMSO as terminal electron acceptor[The number beside a metabolic reaction denotes its net flux, which was normalized by specific rate of glucose uptake](a) top, nitrate; bottom, Fe3+; (b) Top, fumarate; bottom, DMSO
图3 基于代谢通量NADH平衡(NADH生成来自丙酮酸脱氢酶复合体、三羧酸循环和生物质合成。NADH消耗经由电子受体还原。以硝酸作为末端电子受体时NADH消耗不确定)
Fig. 3 NADH balancing based on metabolic flux distributions(NADH is formed by the PDH complex, the TCA cycle and biomass synthesis. NADH was consumed via electron acceptor reduction. NADH consumption rate cannot be determined with nitrate as terminal electron acceptor)
片段 Fragments | 碳原子 C-atom | 前体 precursor | 前体的碳原子 C-atom of precursor | m | m+1 | m+2 | m+3 | m+4 | m+5 | m+6 | m+7 | m+8 | m+9 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
硝酸盐 Nitrate (U-13C) | |||||||||||||
M_ala_057 | 1, 2, 3 | PYR | 1, 2, 3 | 0.7771 | 0.0586 | 0.0285 | 0.1358 | ||||||
M_ala_085 | 2, 3 | PYR | 2, 3 | 0.8027 | 0.0475 | 0.1497 | |||||||
M_asx_057 | 1, 2, 3, 4 | OAA | 1, 2, 3, 4 | 0.6223 | 0.1759 | 0.1167 | 0.0677 | 0.0173 | |||||
M_asx_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.6698 | 0.1857 | 0.1123 | 0.0321 | ||||||
M_asx_302 | 1, 2 | OAA | 1, 2 | 0.7723 | 0.1108 | 0.1169 | |||||||
M_glx_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.5469 | 0.1780 | 0.1864 | 0.0622 | 0.0207 | 0.0059 | ||||
M_glx_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.5910 | 0.1856 | 0.1753 | 0.0357 | 0.0124 | |||||
M_glx_302 | 1, 2 | AKG | 1, 2 | 0.7247 | 0.1880 | 0.0874 | |||||||
M_gly_057 | 1, 2 | 1, 2 | 0.8083 | 0.0612 | 0.1305 | ||||||||
M_gly_085 | 1 | 1 | 0.8354 | 0.1646 | |||||||||
M_his_057 | 1, 2, 3, 4, 5, 6 | R5P | 5, 4, 3, 2, 1 | 0.5227 | 0.1609 | 0.1080 | 0.1325 | 0.0357 | 0.0329 | 0.0073 | |||
M_his_159 | 2, 3, 4, 5, 6 | R5P | 4, 3, 2, 1 | 0.5169 | 0.1612 | 0.2063 | 0.0689 | 0.0355 | 0.0112 | ||||
M_his_302 | 1, 2 | R5P | 5, 4 | 0.7984 | 0.0361 | 0.1654 | |||||||
M_ile_015 | 1, 2, 3, 4, 5, 6 | OAA&PYR | 1,2,3,4&2,3 | 0.5165 | 0.1481 | 0.2009 | 0.0912 | 0.0432 | 0.0000 | 0.0000 | |||
M_ile_085 | 2, 3, 4, 5, 6 | OAA&PYR | 2,3,4&2,3 | 0.5553 | 0.1702 | 0.1861 | 0.0620 | 0.0202 | 0.0063 | ||||
M_leu_015 | 1, 2, 3, 4, 5, 6 | AcoA&PYR | 1,2&2,2,3,3 | 0.5395 | 0.0884 | 0.2743 | 0.0305 | 0.0650 | 0.0023 | 0.0000 | |||
M_leu_085 | 2, 3, 4, 5, 6 | AcoA&PYR | 2&2,2,3,3 | 0.5507 | 0.1606 | 0.2028 | 0.0551 | 0.0254 | 0.0054 | ||||
M_lys_057 | 1, 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 1,2,3,4&3,2/1,2,3&4,3,2 | 0.5194 | 0.1706 | 0.1497 | 0.0992 | 0.0416 | 0.0145 | 0.0049 | |||
M_lys_159 | 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 2,3,4&3,2/2,3& 4,3,2 | 0.5333 | 0.1854 | 0.1893 | 0.0636 | 0.0204 | 0.0080 | ||||
M_lys_302 | 1,2 | OAA/PYR | 1,2/1,2 | 0.6538 | 0.2656 | 0.0807 | |||||||
M_met_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.6959 | 0.2209 | 0.0353 | 0.0297 | 0.0137 | 0.0045 | ||||
M_met_085 | 2,3,4 | OAA | 2,3,4 | 0.7233 | 0.2133 | 0.0389 | 0.0216 | 0.0030 | |||||
M_phe_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.4987 | 0.1004 | 0.0907 | 0.1524 | 0.0706 | 0.0388 | 0.0302 | 0.0125 | 0.0032 | 0.0026 |
M_phe_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.5004 | 0.0965 | 0.1771 | 0.0872 | 0.0709 | 0.0361 | 0.0240 | 0.0046 | 0.0031 | |
M_phe_302 | 1, 2 | PEP | 1, 2 | 0.8280 | 0.0179 | 0.1541 | |||||||
M_phe_sc | 3,4,5,6,7,8,9 | PEP&E4P | 3,2,3&1,2,3,4 | 0.3803 | 0.1470 | 0.1487 | 0.0851 | 0.1094 | 0.0456 | 0.0586 | 0.0252 | ||
M_pro_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.5628 | 0.1626 | 0.1632 | 0.0812 | 0.0226 | 0.0076 | ||||
M_pro_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.6054 | 0.1808 | 0.1667 | 0.0343 | 0.0127 | |||||
M_ser_057 | 1, 2, 3 | 1, 2, 3 | 0.7811 | 0.0469 | 0.0218 | 0.1502 | |||||||
M_ser_085 | 2, 3 | 2, 3 | 0.7845 | 0.0653 | 0.1501 | ||||||||
M_ser_302 | 1, 2 | 1, 2 | 0.8107 | 0.0185 | 0.1708 | ||||||||
M_thr_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.6021 | 0.1815 | 0.1296 | 0.0636 | 0.0233 | |||||
M_thr_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.6554 | 0.1878 | 0.1305 | 0.0262 | ||||||
M_thr_sc | 3,4 | OAA | 3,4 | 0.6432 | 0.2531 | 0.1037 | |||||||
M_val_057 | 1, 2, 3, 4, 5 | PYR | 1, 2, 2, 3, 3 | 0.6424 | 0.0767 | 0.1348 | 0.1113 | 0.0118 | 0.0229 | ||||
M_val_085 | 2, 3, 4, 5 | PYR | 2, 2, 3, 3 | 0.6590 | 0.0690 | 0.2307 | 0.0153 | 0.0260 | |||||
M_val_302 | 1, 2 | PYR | 1, 2 | 0.7932 | 0.0604 | 0.1464 | |||||||
M_tyr_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.4878 | 0.1020 | 0.1013 | 0.1531 | 0.0730 | 0.0398 | 0.0269 | 0.0128 | 0.0032 | 0.0000 |
M_tyr_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.4889 | 0.1005 | 0.1861 | 0.0923 | 0.0695 | 0.0325 | 0.0252 | 0.0037 | 0.0014 | |
M_tyr_302 | 1, 2 | PEP | 1, 2 | 0.8181 | 0.0223 | 0.1596 | |||||||
Fe (U-13C) | |||||||||||||
M_ala_057 | 1, 2, 3 | PYR | 1, 2, 3 | 0.6653 | 0.0687 | 0.0481 | 0.2180 | ||||||
M_ala_085 | 2, 3 | PYR | 2, 3 | 0.7027 | 0.0516 | 0.2457 | |||||||
M_asx_057 | 1, 2, 3, 4 | OAA | 1, 2, 3, 4 | 0.5139 | 0.1980 | 0.0784 | 0.1563 | 0.0534 | |||||
M_asx_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.5856 | 0.1580 | 0.1399 | 0.1165 | ||||||
M_asx_302 | 1, 2 | OAA | 1, 2 | 0.6452 | 0.1865 | 0.1683 | |||||||
M_glx_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.4265 | 0.1428 | 0.2328 | 0.1277 | 0.0408 | 0.0294 | ||||
M_glx_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.4863 | 0.1174 | 0.3028 | 0.0394 | 0.0541 | |||||
M_glx_302 | 1, 2 | AKG | 1, 2 | 0.6145 | 0.2689 | 0.1166 | |||||||
M_gly_057 | 1, 2 | 1, 2 | 0.7073 | 0.1256 | 0.1672 | ||||||||
M_gly_085 | 1 | 1 | 0.7732 | 0.2268 | |||||||||
M_his_057 | 1, 2, 3, 4, 5, 6 | R5P | 5, 4, 3, 2, 1 | 0.5227 | 0.1609 | 0.1080 | 0.1325 | 0.0357 | 0.0329 | 0.0073 | |||
M_his_159 | 2, 3, 4, 5, 6 | R5P | 4, 3, 2, 1 | 0.5169 | 0.1612 | 0.2063 | 0.0689 | 0.0355 | 0.0112 | ||||
M_his_302 | 1, 2 | R5P | 5, 4 | 0.7984 | 0.0361 | 0.1654 | |||||||
M_ile_015 | 1, 2, 3, 4, 5, 6 | OAA&PYR | 1,2,3,4&2,3 | 0.3812 | 0.1562 | 0.1741 | 0.1614 | 0.0538 | 0.0524 | 0.0208 | |||
M_ile_085 | 2, 3, 4, 5, 6 | OAA&PYR | 2,3,4&2,3 | 0.4351 | 0.1340 | 0.2355 | 0.1232 | 0.0412 | 0.0311 | ||||
M_leu_015 | 1, 2, 3, 4, 5, 6 | AcoA&PYR | 1,2&2,2,3,3 | 0.3875 | 0.0690 | 0.3376 | 0.0590 | 0.1262 | 0.0072 | 0.0134 | |||
M_leu_085 | 2, 3, 4, 5, 6 | AcoA&PYR | 2&2,2,3,3 | 0.3941 | 0.1712 | 0.2546 | 0.1107 | 0.0524 | 0.0169 | ||||
M_lys_057 | 1, 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 1,2,3,4&3,2/1,2,3&4,3,2 | 0.3937 | 0.1582 | 0.1451 | 0.1789 | 0.0628 | 0.0405 | 0.0209 | |||
M_lys_159 | 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 2,3,4&3,2/2,3& 4,3,2 | 0.4262 | 0.1373 | 0.2278 | 0.1236 | 0.0429 | 0.0421 | ||||
M_lys_302 | 1,2 | OAA/PYR | 1,2/1,2 | 0.5390 | 0.3428 | 0.1181 | |||||||
M_met_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.3944 | 0.2637 | 0.1093 | 0.1351 | 0.0809 | 0.0167 | ||||
M_met_085 | 2,3,4 | OAA | 2,3,4 | 0.4615 | 0.2480 | 0.1384 | 0.1233 | 0.0288 | |||||
M_phe_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.3504 | 0.0882 | 0.1024 | 0.1830 | 0.0992 | 0.0689 | 0.0587 | 0.0279 | 0.0108 | 0.0106 |
M_phe_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.3535 | 0.0849 | 0.2022 | 0.1126 | 0.1116 | 0.0599 | 0.0527 | 0.0115 | 0.0110 | |
M_phe_302 | 1, 2 | PEP | 1, 2 | 0.7337 | 0.0211 | 0.2451 | |||||||
M_phe_sc | 3,4,5,6,7,8,9 | PEP&E4P | 3,2,3&1,2,3,4 | 0.2751 | 0.1470 | 0.1734 | 0.1093 | 0.1352 | 0.0607 | 0.0709 | 0.0284 | ||
M_pro_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.5409 | 0.1403 | 0.1547 | 0.1071 | 0.0337 | 0.0233 | ||||
M_pro_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.5292 | 0.0996 | 0.2819 | 0.0382 | 0.0511 | |||||
M_ser_057 | 1, 2, 3 | 1, 2, 3 | 0.6402 | 0.1096 | 0.0697 | 0.1805 | |||||||
M_ser_085 | 2, 3 | 2, 3 | 0.6570 | 0.1600 | 0.1830 | ||||||||
M_ser_302 | 1, 2 | 1, 2 | 0.7130 | 0.0548 | 0.2321 | ||||||||
M_thr_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.5067 | 0.1940 | 0.0814 | 0.1609 | 0.0571 | |||||
M_thr_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.5781 | 0.1512 | 0.1539 | 0.1168 | ||||||
M_thr_sc | 3,4 | OAA | 3,4 | 0.5460 | 0.2992 | 0.1549 | |||||||
M_val_057 | 1, 2, 3, 4, 5 | PYR | 1, 2, 2, 3, 3 | 0.5007 | 0.0748 | 0.1878 | 0.1625 | 0.0208 | 0.0535 | ||||
M_val_085 | 2, 3, 4, 5 | PYR | 2, 2, 3, 3 | 0.5210 | 0.0661 | 0.3278 | 0.0241 | 0.0611 | |||||
M_val_302 | 1, 2 | PYR | 1, 2 | 0.6948 | 0.0725 | 0.2327 | |||||||
M_tyr_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.3363 | 0.0843 | 0.1144 | 0.1806 | 0.1059 | 0.0691 | 0.0615 | 0.0273 | 0.0104 | 0.0102 |
M_tyr_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.3358 | 0.0837 | 0.2071 | 0.1196 | 0.1076 | 0.0653 | 0.0558 | 0.0121 | 0.0131 | |
M_tyr_302 | 1, 2 | PEP | 1, 2 | 0.7298 | 0.0199 | 0.2504 | |||||||
延胡索酸 Fumarate(U-13C) | |||||||||||||
M_ala_057 | 1, 2, 3 | PYR | 1, 2, 3 | 0.7549 | 0.0769 | 0.0532 | 0.1149 | ||||||
M_ala_085 | 2, 3 | PYR | 2, 3 | 0.8079 | 0.0369 | 0.1553 | |||||||
M_asx_057 | 1, 2, 3, 4 | OAA | 1, 2, 3, 4 | 0.8566 | 0.0824 | 0.0227 | 0.0326 | 0.0057 | |||||
M_asx_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.8834 | 0.0649 | 0.0371 | 0.0146 | ||||||
M_asx_302 | 1, 2 | OAA | 1, 2 | 0.9028 | 0.0649 | 0.0322 | |||||||
M_glx_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.7139 | 0.0853 | 0.1649 | 0.0262 | 0.0071 | 0.0027 | ||||
M_glx_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.7417 | 0.0774 | 0.1629 | 0.0098 | 0.0083 | |||||
M_glx_302 | 1, 2 | AKG | 1, 2 | 0.8524 | 0.1177 | 0.0300 | |||||||
M_gly_057 | 1, 2 | 1, 2 | 0.8221 | 0.0534 | 0.1245 | ||||||||
M_gly_085 | 1 | 1 | 0.8500 | 0.1500 | |||||||||
M_his_057 | 1, 2, 3, 4, 5, 6 | R5P | 5, 4, 3, 2, 1 | 0.5227 | 0.1609 | 0.1080 | 0.1325 | 0.0357 | 0.0329 | 0.0073 | |||
M_his_159 | 2, 3, 4, 5, 6 | R5P | 4, 3, 2, 1 | 0.5169 | 0.1612 | 0.2063 | 0.0689 | 0.0355 | 0.0112 | ||||
M_his_302 | 1, 2 | R5P | 5, 4 | 0.7984 | 0.0361 | 0.1654 | |||||||
M_ile_015 | 1, 2, 3, 4, 5, 6 | OAA&PYR | 1,2,3,4&2,3 | 0.6803 | 0.1019 | 0.1614 | 0.0377 | 0.0149 | 0.0038 | 0.0000 | |||
M_ile_085 | 2, 3, 4, 5, 6 | OAA&PYR | 2,3,4&2,3 | 0.6985 | 0.0910 | 0.1743 | 0.0255 | 0.0079 | 0.0027 | ||||
M_leu_015 | 1, 2, 3, 4, 5, 6 | AcoA&PYR | 1,2&2,2,3,3 | 0.5413 | 0.0739 | 0.2895 | 0.0299 | 0.0604 | 0.0006 | 0.0045 | |||
M_leu_085 | 2, 3, 4, 5, 6 | AcoA&PYR | 2&2,2,3,3 | 0.5449 | 0.1569 | 0.2142 | 0.0551 | 0.0240 | 0.0048 | ||||
M_lys_057 | 1, 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 1,2,3,4&3,2/1,2,3&4,3,2 | 0.6674 | 0.1133 | 0.1150 | 0.0846 | 0.0119 | 0.0062 | 0.0016 | |||
M_lys_159 | 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 2,3,4&3,2/2,3&4,3,2 | 0.6967 | 0.0906 | 0.1707 | 0.0279 | 0.0100 | 0.0040 | ||||
M_lys_302 | 1,2 | OAA/PYR | 1,2/1,2 | 0.7318 | 0.2435 | 0.0247 | |||||||
M_met_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.6959 | 0.2209 | 0.0353 | 0.0297 | 0.0137 | 0.0045 | ||||
M_met_085 | 2,3,4 | OAA | 2,3,4 | 0.7233 | 0.2133 | 0.0389 | 0.0216 | 0.0030 | |||||
M_phe_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.4690 | 0.1018 | 0.1024 | 0.1654 | 0.0744 | 0.0383 | 0.0293 | 0.0131 | 0.0033 | 0.0030 |
M_phe_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.4716 | 0.1001 | 0.1908 | 0.0929 | 0.0788 | 0.0329 | 0.0263 | 0.0036 | 0.0029 | |
M_phe_302 | 1, 2 | PEP | 1, 2 | 0.8166 | 0.0181 | 0.1653 | |||||||
M_phe_sc | 3,4,5,6,7,8,9 | PEP&E4P | 3,2,3&1,2,3,4 | 0.3993 | 0.1696 | 0.1489 | 0.0949 | 0.0984 | 0.0384 | 0.0504 | |||
M_pro_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.6515 | 0.0727 | 0.1395 | 0.1168 | 0.0162 | 0.0033 | ||||
M_pro_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.7504 | 0.0787 | 0.1576 | 0.0060 | 0.0073 | |||||
M_ser_057 | 1, 2, 3 | 1, 2, 3 | 0.7535 | 0.0701 | 0.0430 | 0.1334 | |||||||
M_ser_085 | 2, 3 | 2, 3 | 0.7630 | 0.1045 | 0.1325 | ||||||||
M_ser_302 | 1, 2 | 1, 2 | 0.7998 | 0.0287 | 0.1715 | ||||||||
M_thr_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.8495 | 0.0858 | 0.0229 | 0.0346 | 0.0072 | |||||
M_thr_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.8791 | 0.0609 | 0.0440 | 0.0160 | ||||||
M_thr_sc | 3,4 | OAA | 3,4 | 0.7799 | 0.1869 | 0.0332 | |||||||
M_val_057 | 1, 2, 3, 4, 5 | PYR | 1, 2, 2, 3, 3 | 0.6138 | 0.0911 | 0.1594 | 0.1045 | 0.0120 | 0.0193 | ||||
M_val_085 | 2, 3, 4, 5 | PYR | 2, 2, 3, 3 | 0.6486 | 0.0641 | 0.2490 | 0.0122 | 0.0261 | |||||
M_val_302 | 1, 2 | PYR | 1, 2 | 0.7650 | 0.0993 | 0.1357 | |||||||
M_tyr_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.4588 | 0.1002 | 0.1068 | 0.1695 | 0.0761 | 0.0369 | 0.0308 | 0.0138 | 0.0029 | 0.0043 |
M_tyr_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.4680 | 0.0996 | 0.1933 | 0.0916 | 0.0816 | 0.0338 | 0.0243 | 0.0042 | 0.0037 | |
M_tyr_302 | 1, 2 | PEP | 1, 2 | 0.8064 | 0.0214 | 0.1722 | |||||||
DMSO(U-13C) | |||||||||||||
M_ala_057 | 1, 2, 3 | PYR | 1, 2, 3 | 0.7596 | 0.0505 | 0.0361 | 0.1538 | ||||||
M_ala_085 | 2, 3 | PYR | 2, 3 | 0.7778 | 0.0509 | 0.1713 | |||||||
M_asx_057 | 1, 2, 3, 4 | OAA | 1, 2, 3, 4 | 0.6192 | 0.1729 | 0.0738 | 0.1092 | 0.0249 | |||||
M_asx_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.6709 | 0.1582 | 0.1114 | 0.0596 | ||||||
M_asx_302 | 1, 2 | OAA | 1, 2 | 0.7382 | 0.1339 | 0.1279 | |||||||
M_glx_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.5272 | 0.1559 | 0.2052 | 0.0792 | 0.0224 | 0.0102 | ||||
M_glx_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.5823 | 0.1361 | 0.2267 | 0.0291 | 0.0258 | |||||
M_glx_302 | 1, 2 | AKG | 1, 2 | 0.6949 | 0.2244 | 0.0807 | |||||||
M_gly_057 | 1, 2 | 1, 2 | 0.7738 | 0.0761 | 0.1501 | ||||||||
M_gly_085 | 1 | 1 | 0.8112 | 0.1888 | |||||||||
M_his_057 | 1, 2, 3, 4, 5, 6 | R5P | 5, 4, 3, 2, 1 | 0.5227 | 0.1609 | 0.1080 | 0.1325 | 0.0357 | 0.0329 | 0.0073 | |||
M_his_159 | 2, 3, 4, 5, 6 | R5P | 4, 3, 2, 1 | 0.5169 | 0.1612 | 0.2063 | 0.0689 | 0.0355 | 0.0112 | ||||
M_his_302 | 1, 2 | R5P | 5, 4 | 0.7984 | 0.0361 | 0.1654 | |||||||
M_ile_015 | 1, 2, 3, 4, 5, 6 | OAA&PYR | 1,2,3,4&2,3 | 0.5000 | 0.1680 | 0.1581 | 0.1163 | 0.0465 | 0.0112 | 0.0000 | |||
M_ile_085 | 2, 3, 4, 5, 6 | OAA&PYR | 2,3,4&2,3 | 0.5293 | 0.1528 | 0.2062 | 0.0789 | 0.0209 | 0.0119 | ||||
M_leu_015 | 1, 2, 3, 4, 5, 6 | AcoA&PYR | 1,2&2,2,3,3 | 0.4933 | 0.1014 | 0.3028 | 0.0354 | 0.0606 | 0.0064 | 0.0000 | |||
M_leu_085 | 2, 3, 4, 5, 6 | AcoA&PYR | 2&2,2,3,3 | 0.5086 | 0.1741 | 0.2230 | 0.0623 | 0.0258 | 0.0061 | ||||
M_lys_057 | 1, 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 1,2,3,4&3,2/1,2,3&4,3,2 | 0.5194 | 0.1706 | 0.1497 | 0.0992 | 0.0416 | 0.0145 | 0.0049 | |||
M_lys_159 | 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 2,3,4&3,2/2,3& 4,3,2 | 0.5333 | 0.1854 | 0.1893 | 0.0636 | 0.0204 | 0.0080 | ||||
M_lys_302 | 1,2 | OAA/PYR | 1,2/1,2 | 0.6538 | 0.2656 | 0.0807 | |||||||
M_met_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.5209 | 0.2351 | 0.0858 | 0.1153 | 0.0357 | 0.0073 | ||||
M_met_085 | 2,3,4 | OAA | 2,3,4 | 0.5631 | 0.2369 | 0.1186 | 0.0545 | 0.0269 | |||||
M_phe_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3& 1, 2, 3, 4 | 0.4415 | 0.1047 | 0.1088 | 0.1722 | 0.0743 | 0.0451 | 0.0320 | 0.0133 | 0.0049 | 0.0032 |
M_phe_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.4505 | 0.1030 | 0.1953 | 0.1010 | 0.0781 | 0.0390 | 0.0256 | 0.0044 | 0.0032 | |
M_phe_302 | 1, 2 | PEP | 1, 2 | 0.8022 | 0.0251 | 0.1727 | |||||||
M_phe_sc | 3,4,5,6,7,8,9 | PEP&E4P | 3,2,3&1,2,3,4 | 0.3191 | 0.1447 | 0.1799 | 0.0898 | 0.1191 | 0.0467 | 0.0694 | 0.0313 | ||
M_pro_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.6670 | 0.1257 | 0.0716 | 0.0936 | 0.0306 | 0.0115 | ||||
M_pro_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.6131 | 0.1116 | 0.2324 | 0.0130 | 0.0299 | |||||
M_ser_057 | 1, 2, 3 | 1, 2, 3 | 0.7470 | 0.0797 | 0.0484 | 0.1249 | |||||||
M_ser_085 | 2, 3 | 2, 3 | 0.7718 | 0.1342 | 0.0940 | ||||||||
M_ser_302 | 1, 2 | 1, 2 | 0.7695 | 0.0896 | 0.1410 | ||||||||
M_thr_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.6153 | 0.1799 | 0.0688 | 0.1098 | 0.0262 | |||||
M_thr_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.6649 | 0.1601 | 0.1175 | 0.0575 | ||||||
M_thr_sc | 3,4 | OAA | 3,4 | 0.6324 | 0.2705 | 0.0970 | |||||||
M_val_057 | 1, 2, 3, 4, 5 | PYR | 1, 2, 2, 3, 3 | 0.6111 | 0.0749 | 0.1489 | 0.1245 | 0.0132 | 0.0274 | ||||
M_val_085 | 2, 3, 4, 5 | PYR | 2, 2, 3, 3 | 0.6224 | 0.0756 | 0.2601 | 0.0144 | 0.0274 | |||||
M_val_302 | 1, 2 | PYR | 1, 2 | 0.7795 | 0.0448 | 0.1757 | |||||||
M_tyr_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3& 1, 2, 3, 4 | 0.4346 | 0.1068 | 0.1137 | 0.1947 | 0.0657 | 0.0496 | 0.0234 | 0.0107 | 0.0000 | 0.0008 |
M_tyr_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.4182 | 0.0981 | 0.1878 | 0.1259 | 0.0942 | 0.0459 | 0.0287 | 0.0000 | 0.0013 | |
M_tyr_302 | 1, 2 | PEP | 1, 2 | 0.7929 | 0.0251 | 0.1821 | |||||||
硝酸盐 Nitrate(1-13C) | |||||||||||||
M_ala_057 | 1, 2, 3 | PYR | 1, 2, 3 | 0.5398 | 0.4523 | 0.0079 | 0.0000 | ||||||
M_ala_085 | 2, 3 | PYR | 2, 3 | 0.9793 | 0.0207 | 0.0000 | |||||||
M_asx_057 | 1, 2, 3, 4 | OAA | 1, 2, 3, 4 | 0.7515 | 0.1998 | 0.0485 | 0.0000 | 0.0002 | |||||
M_asx_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.8524 | 0.1461 | 0.0015 | 0.0000 | ||||||
M_asx_302 | 1, 2 | OAA | 1, 2 | 0.8451 | 0.1546 | 0.0003 | |||||||
M_glx_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.8287 | 0.1641 | 0.0068 | 0.0000 | 0.0003 | 0.0000 | ||||
M_glx_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.9262 | 0.0711 | 0.0020 | 0.0004 | 0.0004 | |||||
M_glx_302 | 1, 2 | AKG | 1, 2 | 0.8445 | 0.1554 | 0.0000 | |||||||
M_gly_057 | 1, 2 | 1, 2 | 0.8995 | 0.0979 | 0.0026 | ||||||||
M_gly_085 | 1 | 1 | 0.9867 | 0.0133 | |||||||||
M_his_057 | 1, 2, 3, 4, 5, 6 | R5P | 5, 4, 3, 2, 1 | 0.4425 | 0.4269 | 0.1183 | 0.0116 | 0.0002 | 0.0005 | 0.0000 | |||
M_his_159 | 2, 3, 4, 5, 6 | R5P | 4, 3, 2, 1 | 0.4720 | 0.4370 | 0.0742 | 0.0107 | 0.0044 | 0.0017 | ||||
M_his_302 | 1, 2 | R5P | 5, 4 | 0.8912 | 0.1088 | 0.0000 | |||||||
M_ile_015 | 1, 2, 3, 4, 5, 6 | OAA&PYR | 1,2,3,4&2,3 | 0.7233 | 0.2029 | 0.0583 | 0.0103 | 0.0041 | 0.0011 | 0.0000 | |||
M_ile_085 | 2, 3, 4, 5, 6 | OAA&PYR | 2,3,4&2,3 | 0.8226 | 0.1686 | 0.0083 | 0.0002 | 0.0002 | 0.0002 | ||||
M_leu_015 | 1, 2, 3, 4, 5, 6 | AcoA&PYR | 1,2&2,2,3,3 | 0.9312 | 0.0618 | 0.0010 | 0.0054 | 0.0005 | 0.0000 | 0.0001 | |||
M_leu_085 | 2, 3, 4, 5, 6 | AcoA&PYR | 2&2,2,3,3 | 0.9350 | 0.0645 | 0.0003 | 0.0002 | 0.0001 | 0.0000 | ||||
M_lys_057 | 1, 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 1,2,3,4&3,2/1,2,3&4,3,2 | 0.4759 | 0.3053 | 0.1717 | 0.0000 | 0.0246 | 0.0083 | 0.0142 | |||
M_lys_159 | 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 2,3,4&3,2/2,3& 4,3,2 | 0.2194 | 0.0498 | 0.1072 | 0.1872 | 0.3795 | 0.0569 | ||||
M_lys_302 | 1,2 | OAA/PYR | 1,2/1,2 | 0.6946 | 0.2732 | 0.0322 | |||||||
M_met_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.7313 | 0.2028 | 0.0503 | 0.0086 | 0.0027 | 0.0042 | ||||
M_met_085 | 2,3,4 | OAA | 2,3,4 | 0.8263 | 0.1619 | 0.0072 | 0.0032 | 0.0014 | |||||
M_phe_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.8884 | 0.1044 | 0.0041 | 0.0009 | 0.0001 | 0.0007 | 0.0005 | 0.0005 | 0.0003 | 0.0002 |
M_phe_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.8961 | 0.0939 | 0.0041 | 0.0018 | 0.0006 | 0.0008 | 0.0007 | 0.0015 | 0.0004 | |
M_phe_302 | 1, 2 | PEP | 1, 2 | 0.9771 | 0.0229 | 0.0000 | |||||||
M_phe_sc | 3,4,5,6,7,8,9 | PEP&E4P | 3,2,3&1,2,3,4 | 0.7523 | 0.0947 | 0.0332 | 0.0085 | 0.0215 | 0.0207 | 0.0405 | 0.0286 | ||
M_pro_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.8748 | 0.1149 | 0.0000 | 0.0042 | 0.0045 | 0.0016 | ||||
M_pro_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.9366 | 0.0612 | 0.0011 | 0.0000 | 0.0010 | |||||
M_ser_057 | 1, 2, 3 | 1, 2, 3 | 0.9605 | 0.0391 | 0.0000 | 0.0004 | |||||||
M_ser_085 | 2, 3 | 2, 3 | 0.9810 | 0.0190 | 0.0000 | ||||||||
M_ser_302 | 1, 2 | 1, 2 | 0.9667 | 0.0304 | 0.0029 | ||||||||
M_thr_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.7489 | 0.1979 | 0.0517 | 0.0007 | 0.0008 | |||||
M_thr_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.8435 | 0.1479 | 0.0086 | 0.0000 | ||||||
M_thr_sc | 3,4 | OAA | 3,4 | 0.7463 | 0.2252 | 0.0285 | |||||||
M_val_057 | 1, 2, 3, 4, 5 | PYR | 1, 2, 2, 3, 3 | 0.5218 | 0.4572 | 0.0200 | 0.0009 | 0.0000 | 0.0000 | ||||
M_val_085 | 2, 3, 4, 5 | PYR | 2, 2, 3, 3 | 0.9458 | 0.0511 | 0.0027 | 0.0003 | 0.0002 | |||||
M_val_302 | 1, 2 | PYR | 1, 2 | 0.5866 | 0.4116 | 0.0018 | |||||||
M_tyr_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.8800 | 0.1030 | 0.0044 | 0.0000 | 0.0011 | 0.0004 | 0.0006 | 0.0006 | 0.0031 | 0.0068 |
M_tyr_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.8890 | 0.0969 | 0.0014 | 0.0011 | 0.0011 | 0.0014 | 0.0002 | 0.0047 | 0.0042 | |
M_tyr_302 | 1, 2 | PEP | 1, 2 | 0.9779 | 0.0220 | 0.0001 | |||||||
Fe (1-13C) | |||||||||||||
M_ala_057 | 1, 2, 3 | PYR | 1, 2, 3 | 0.5273 | 0.4640 | 0.0088 | 0.0000 | ||||||
M_ala_085 | 2, 3 | PYR | 2, 3 | 0.9764 | 0.0230 | 0.0006 | |||||||
M_asx_057 | 1, 2, 3, 4 | OAA | 1, 2, 3, 4 | 0.3476 | 0.4571 | 0.1910 | 0.0043 | 0.0000 | |||||
M_asx_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.5600 | 0.4314 | 0.0086 | 0.0000 | ||||||
M_asx_302 | 1, 2 | OAA | 1, 2 | 0.5890 | 0.4087 | 0.0023 | |||||||
M_glx_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.5616 | 0.4186 | 0.0195 | 0.0002 | 0.0000 | 0.0000 | ||||
M_glx_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.8990 | 0.0986 | 0.0020 | 0.0000 | 0.0004 | |||||
M_glx_302 | 1, 2 | AKG | 1, 2 | 0.6891 | 0.3048 | 0.0062 | |||||||
M_gly_057 | 1, 2 | 1, 2 | 0.7664 | 0.2334 | 0.0002 | ||||||||
M_gly_085 | 1 | 1 | 0.9934 | 0.0066 | |||||||||
M_his_057 | 1, 2, 3, 4, 5, 6 | R5P | 5, 4, 3, 2, 1 | 0.4425 | 0.4269 | 0.1183 | 0.0116 | 0.0002 | 0.0005 | 0.0000 | |||
M_his_159 | 2, 3, 4, 5, 6 | R5P | 4, 3, 2, 1 | 0.4720 | 0.4370 | 0.0742 | 0.0107 | 0.0044 | 0.0017 | ||||
M_his_302 | 1, 2 | R5P | 5, 4 | 0.8912 | 0.1088 | 0.0000 | |||||||
M_ile_015 | 1, 2, 3, 4, 5, 6 | OAA&PYR | 1,2,3,4&2,3 | 0.3508 | 0.4485 | 0.1854 | 0.0134 | 0.0019 | 0.0000 | 0.0000 | |||
M_ile_085 | 2, 3, 4, 5, 6 | OAA&PYR | 2,3,4&2,3 | 0.5499 | 0.4265 | 0.0229 | 0.0000 | 0.0007 | 0.0000 | ||||
M_leu_015 | 1, 2, 3, 4, 5, 6 | AcoA&PYR | 1,2&2,2,3,3 | 0.9468 | 0.0484 | 0.0017 | 0.0029 | 0.0000 | 0.0000 | 0.0002 | |||
M_leu_085 | 2, 3, 4, 5, 6 | AcoA&PYR | 2&2,2,3,3 | 0.9339 | 0.0657 | 0.0001 | 0.0001 | 0.0002 | 0.0000 | ||||
M_lys_057 | 1, 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 1,2,3,4&3,2/ 1,2,3&4,3,2 | 0.3053 | 0.4567 | 0.2213 | 0.0123 | 0.0005 | 0.0025 | 0.0014 | |||
M_lys_159 | 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 2,3,4&3,2/2,3& 4,3,2 | 0.4979 | 0.4162 | 0.0247 | 0.0080 | 0.0057 | 0.0474 | ||||
M_lys_302 | 1,2 | OAA/PYR | 1,2/1,2 | 0.8733 | 0.1267 | 0.0000 | |||||||
M_met_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.3424 | 0.4536 | 0.1957 | 0.0079 | 0.0000 | 0.0004 | ||||
M_met_085 | 2,3,4 | OAA | 2,3,4 | 0.5530 | 0.4297 | 0.0165 | 0.0000 | 0.0008 | |||||
M_phe_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3& 1, 2, 3, 4 | 0.8883 | 0.1064 | 0.0045 | 0.0000 | 0.0002 | 0.0001 | 0.0001 | 0.0002 | 0.0000 | 0.0000 |
M_phe_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.8976 | 0.0996 | 0.0021 | 0.0002 | 0.0000 | 0.0003 | 0.0001 | 0.0001 | 0.0000 | |
M_phe_302 | 1, 2 | PEP | 1, 2 | 0.9859 | 0.0141 | 0.0000 | |||||||
M_phe_sc | 3,4,5,6,7,8,9 | PEP&E4P | 3,2,3&1,2,3,4 | 0.7505 | 0.0973 | 0.0400 | 0.0097 | 0.0295 | 0.0126 | 0.0372 | 0.0232 | ||
M_pro_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.6058 | 0.3772 | 0.0109 | 0.0043 | 0.0011 | 0.0008 | ||||
M_pro_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.8992 | 0.0964 | 0.0039 | 0.0002 | 0.0004 | |||||
M_ser_057 | 1, 2, 3 | 1, 2, 3 | 0.9242 | 0.0736 | 0.0021 | 0.0000 | |||||||
M_ser_085 | 2, 3 | 2, 3 | 0.9848 | 0.0152 | 0.0000 | ||||||||
M_ser_302 | 1, 2 | 1, 2 | 0.9275 | 0.0696 | 0.0029 | ||||||||
M_thr_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.3373 | 0.4592 | 0.2014 | 0.0021 | 0.0000 | |||||
M_thr_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.5589 | 0.4272 | 0.0135 | 0.0004 | ||||||
M_thr_sc | 3,4 | OAA | 3,4 | 0.5019 | 0.4845 | 0.0136 | |||||||
M_val_057 | 1, 2, 3, 4, 5 | PYR | 1, 2, 2, 3, 3 | 0.5165 | 0.4582 | 0.0251 | 0.0000 | 0.0000 | 0.0002 | ||||
M_val_085 | 2, 3, 4, 5 | PYR | 2, 2, 3, 3 | 0.9413 | 0.0551 | 0.0033 | 0.0000 | 0.0003 | |||||
M_val_302 | 1, 2 | PYR | 1, 2 | 0.5793 | 0.4195 | 0.0012 | |||||||
M_tyr_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.8856 | 0.1102 | 0.0031 | 0.0000 | 0.0005 | 0.0005 | 0.0000 | 0.0000 | 0.0000 | 0.0000 |
M_tyr_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.8974 | 0.0979 | 0.0021 | 0.0018 | 0.0000 | 0.0005 | 0.0002 | 0.0000 | 0.0000 | |
M_tyr_302 | 1, 2 | PEP | 1, 2 | 0.9857 | 0.0143 | 0.0000 | |||||||
延胡索酸 Fumarate (1-13C) | |||||||||||||
M_ala_057 | 1, 2, 3 | PYR | 1, 2, 3 | 0.5836 | 0.4087 | 0.0077 | 0.0000 | ||||||
M_ala_085 | 2, 3 | PYR | 2, 3 | 0.9776 | 0.0224 | 0.0000 | |||||||
M_asx_057 | 1, 2, 3, 4 | OAA | 1, 2, 3, 4 | 0.9250 | 0.0653 | 0.0090 | 0.0000 | 0.0008 | |||||
M_asx_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.9468 | 0.0532 | 0.0000 | 0.0000 | ||||||
M_asx_302 | 1, 2 | OAA | 1, 2 | 0.9549 | 0.0441 | 0.0009 | |||||||
M_glx_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.9232 | 0.0758 | 0.0000 | 0.0009 | 0.0000 | 0.0001 | ||||
M_glx_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.9509 | 0.0490 | 0.0000 | 0.0000 | 0.0000 | |||||
M_glx_302 | 1, 2 | AKG | 1, 2 | 0.9143 | 0.0857 | 0.0000 | |||||||
M_gly_057 | 1, 2 | 1, 2 | 0.8501 | 0.1485 | 0.0014 | ||||||||
M_gly_085 | 1 | 1 | 0.9928 | 0.0072 | |||||||||
M_his_057 | 1, 2, 3, 4, 5, 6 | R5P | 5, 4, 3, 2, 1 | 0.4425 | 0.4269 | 0.1183 | 0.0116 | 0.0002 | 0.0005 | 0.0000 | |||
M_his_159 | 2, 3, 4, 5, 6 | R5P | 4, 3, 2, 1 | 0.4720 | 0.4370 | 0.0742 | 0.0107 | 0.0044 | 0.0017 | ||||
M_his_302 | 1, 2 | R5P | 5, 4 | 0.8912 | 0.1088 | 0.0000 | |||||||
M_ile_015 | 1, 2, 3, 4, 5, 6 | OAA&PYR | 1,2,3,4&2,3 | 0.8896 | 0.0983 | 0.0109 | 0.0000 | 0.0009 | 0.0000 | 0.0003 | |||
M_ile_085 | 2, 3, 4, 5, 6 | OAA&PYR | 2,3,4&2,3 | 0.9197 | 0.0794 | 0.0003 | 0.0000 | 0.0005 | 0.0000 | ||||
M_leu_015 | 1, 2, 3, 4, 5, 6 | AcoA&PYR | 1,2&2,2,3,3 | 0.9294 | 0.0674 | 0.0030 | 0.0000 | 0.0000 | 0.0000 | 0.0002 | |||
M_leu_085 | 2, 3, 4, 5, 6 | AcoA&PYR | 2&2,2,3,3 | 0.9340 | 0.0657 | 0.0000 | 0.0000 | 0.0002 | 0.0001 | ||||
M_lys_057 | 1, 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 1,2,3,4&3,2/1,2,3&4,3,2 | 0.7096 | 0.2448 | 0.0374 | 0.0065 | 0.0000 | 0.0000 | 0.0017 | |||
M_lys_159 | 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 2,3,4&3,2/2,3& 4,3,2 | 0.8280 | 0.1000 | 0.0134 | 0.0026 | 0.0091 | 0.0469 | ||||
M_lys_302 | 1,2 | OAA/PYR | 1,2/1,2 | 0.8531 | 0.1469 | 0.0000 | |||||||
M_met_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.9177 | 0.0766 | 0.0000 | 0.0030 | 0.0014 | 0.0013 | ||||
M_met_085 | 2,3,4 | OAA | 2,3,4 | 0.9272 | 0.0717 | 0.0000 | 0.0000 | 0.0011 | |||||
M_phe_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.8943 | 0.0981 | 0.0068 | 0.0000 | 0.0000 | 0.0004 | 0.0001 | 0.0003 | 0.0000 | 0.0000 |
M_phe_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.8958 | 0.0995 | 0.0035 | 0.0002 | 0.0001 | 0.0005 | 0.0003 | 0.0001 | 0.0000 | |
M_phe_302 | 1, 2 | PEP | 1, 2 | 0.9865 | 0.0135 | 0.0000 | |||||||
M_phe_sc | 3,4,5,6,7,8,9 | PEP&E4P | 3,2,3&1,2,3,4 | 0.7512 | 0.0956 | 0.0420 | 0.0092 | 0.0288 | 0.0134 | 0.0346 | 0.0251 | ||
M_pro_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.7781 | 0.0692 | 0.0009 | 0.1459 | 0.0060 | 0.0000 | ||||
M_pro_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.9442 | 0.0556 | 0.0000 | 0.0000 | 0.0001 | |||||
M_ser_057 | 1, 2, 3 | 1, 2, 3 | 0.9120 | 0.0857 | 0.0023 | 0.0000 | |||||||
M_ser_085 | 2, 3 | 2, 3 | 0.9798 | 0.0202 | 0.0000 | ||||||||
M_ser_302 | 1, 2 | 1, 2 | 0.9211 | 0.0789 | 0.0000 | ||||||||
M_thr_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.9300 | 0.0609 | 0.0088 | 0.0000 | 0.0003 | |||||
M_thr_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.9517 | 0.0464 | 0.0019 | 0.0000 | ||||||
M_thr_sc | 3,4 | OAA | 3,4 | 0.8347 | 0.1521 | 0.0131 | |||||||
M_val_057 | 1, 2, 3, 4, 5 | PYR | 1, 2, 2, 3, 3 | 0.5676 | 0.4133 | 0.0184 | 0.0000 | 0.0006 | 0.0001 | ||||
M_val_085 | 2, 3, 4, 5 | PYR | 2, 2, 3, 3 | 0.9485 | 0.0511 | 0.0000 | 0.0001 | 0.0003 | |||||
M_val_302 | 1, 2 | PYR | 1, 2 | 0.6328 | 0.3672 | 0.0000 | |||||||
M_tyr_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.8977 | 0.1009 | 0.0000 | 0.0007 | 0.0006 | 0.0001 | 0.0000 | 0.0000 | 0.0000 | 0.0000 |
M_tyr_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.9080 | 0.0882 | 0.0002 | 0.0018 | 0.0016 | 0.0000 | 0.0000 | 0.0000 | 0.0001 | |
M_tyr_302 | 1, 2 | PEP | 1, 2 | 0.9834 | 0.0166 | 0.0000 | |||||||
DMSO (1-13C) | |||||||||||||
M_ala_057 | 1, 2, 3 | PYR | 1, 2, 3 | 0.5872 | 0.4050 | 0.0078 | 0.0000 | ||||||
M_ala_085 | 2, 3 | PYR | 2, 3 | 0.9792 | 0.0208 | 0.0000 | |||||||
M_asx_057 | 1, 2, 3, 4 | OAA | 1, 2, 3, 4 | 0.9336 | 0.0586 | 0.0075 | 0.0002 | 0.0000 | |||||
M_asx_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.9558 | 0.0440 | 0.0000 | 0.0002 | ||||||
M_asx_302 | 1, 2 | OAA | 1, 2 | 0.9664 | 0.0336 | 0.0000 | |||||||
M_glx_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.9268 | 0.0723 | 0.0000 | 0.0009 | 0.0000 | 0.0000 | ||||
M_glx_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.9477 | 0.0500 | 0.0000 | 0.0023 | 0.0000 | |||||
M_glx_302 | 1, 2 | AKG | 1, 2 | 0.8997 | 0.1003 | 0.0000 | |||||||
M_gly_057 | 1, 2 | 1, 2 | 0.8728 | 0.1263 | 0.0010 | ||||||||
M_gly_085 | 1 | 1 | 0.9910 | 0.0090 | |||||||||
M_his_057 | 1, 2, 3, 4, 5, 6 | R5P | 5, 4, 3, 2, 1 | 0.4425 | 0.4269 | 0.1183 | 0.0116 | 0.0002 | 0.0005 | 0.0000 | |||
M_his_159 | 2, 3, 4, 5, 6 | R5P | 4, 3, 2, 1 | 0.4720 | 0.4370 | 0.0742 | 0.0107 | 0.0044 | 0.0017 | ||||
M_his_302 | 1, 2 | R5P | 5, 4 | 0.8912 | 0.1088 | 0.0000 | |||||||
M_ile_015 | 1, 2, 3, 4, 5, 6 | OAA&PYR | 1,2,3,4&2,3 | 0.8904 | 0.0931 | 0.0158 | 0.0000 | 0.0000 | 0.0003 | 0.0003 | |||
M_ile_085 | 2, 3, 4, 5, 6 | OAA&PYR | 2,3,4&2,3 | 0.9199 | 0.0786 | 0.0011 | 0.0002 | 0.0002 | 0.0000 | ||||
M_leu_015 | 1, 2, 3, 4, 5, 6 | AcoA&PYR | 1,2&2,2,3,3 | 0.9369 | 0.0608 | 0.0000 | 0.0016 | 0.0005 | 0.0000 | 0.0002 | |||
M_leu_085 | 2, 3, 4, 5, 6 | AcoA&PYR | 2&2,2,3,3 | 0.9308 | 0.0688 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | ||||
M_lys_057 | 1, 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 1,2,3,4&3,2/1,2,3&4,3,2 | 0.7104 | 0.2644 | 0.0183 | 0.0053 | 0.0013 | 0.0002 | 0.0000 | |||
M_lys_159 | 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 2,3,4&3,2/2,3&4,3,2 | 0.8848 | 0.0838 | 0.0017 | 0.0073 | 0.0019 | 0.0205 | ||||
M_lys_302 | 1,2 | OAA/PYR | 1,2/1,2 | 0.8678 | 0.1322 | 0.0000 | |||||||
M_met_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.9140 | 0.0749 | 0.0080 | 0.0024 | 0.0000 | 0.0007 | ||||
M_met_085 | 2,3,4 | OAA | 2,3,4 | 0.9399 | 0.0595 | 0.0005 | 0.0000 | 0.0000 | |||||
M_phe_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.8961 | 0.0999 | 0.0018 | 0.0016 | 0.0000 | 0.0001 | 0.0003 | 0.0001 | 0.0000 | 0.0000 |
M_phe_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.8960 | 0.0987 | 0.0045 | 0.0000 | 0.0003 | 0.0002 | 0.0002 | 0.0001 | 0.0000 | |
M_phe_302 | 1, 2 | PEP | 1, 2 | 0.9835 | 0.0165 | 0.0000 | |||||||
M_phe_sc | 3,4,5,6,7,8,9 | PEP&E4P | 3,2,3&1,2,3,4 | 0.7579 | 0.1032 | 0.0376 | 0.0077 | 0.0256 | 0.0115 | 0.0368 | 0.0197 | ||
M_pro_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.6492 | 0.0545 | 0.0009 | 0.2896 | 0.0058 | 0.0000 | ||||
M_pro_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.9422 | 0.0553 | 0.0000 | 0.0024 | 0.0001 | |||||
M_ser_057 | 1, 2, 3 | 1, 2, 3 | 0.9195 | 0.0803 | 0.0000 | 0.0002 | |||||||
M_ser_085 | 2, 3 | 2, 3 | 0.9858 | 0.0142 | 0.0000 | ||||||||
M_ser_302 | 1, 2 | 1, 2 | 0.9235 | 0.0728 | 0.0036 | ||||||||
M_thr_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.9335 | 0.0616 | 0.0039 | 0.0004 | 0.0006 | |||||
M_thr_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.9571 | 0.0400 | 0.0000 | 0.0028 | ||||||
M_thr_sc | 3,4 | OAA | 3,4 | 0.8412 | 0.1503 | 0.0085 | |||||||
M_val_057 | 1, 2, 3, 4, 5 | PYR | 1, 2, 2, 3, 3 | 0.5633 | 0.4172 | 0.0193 | 0.0000 | 0.0000 | 0.0002 | ||||
M_val_085 | 2, 3, 4, 5 | PYR | 2, 2, 3, 3 | 0.9400 | 0.0552 | 0.0048 | 0.0000 | 0.0000 | |||||
M_val_302 | 1, 2 | PYR | 1, 2 | 0.6248 | 0.3687 | 0.0065 | |||||||
M_tyr_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.8903 | 0.1039 | 0.0056 | 0.0001 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 |
M_tyr_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.8916 | 0.1056 | 0.0000 | 0.0005 | 0.0016 | 0.0007 | 0.0000 | 0.0000 | 0.0001 | |
M_tyr_302 | 1, 2 | PEP | 1, 2 | 0.9859 | 0.0141 | 0.0000 |
(The symbols of fragments denote the cracking patterns of TBDMS-derivatized amino acids:(M-57)+,(M-85)+,(M-159)+ and f302 fragments)
片段 Fragments | 碳原子 C-atom | 前体 precursor | 前体的碳原子 C-atom of precursor | m | m+1 | m+2 | m+3 | m+4 | m+5 | m+6 | m+7 | m+8 | m+9 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
硝酸盐 Nitrate (U-13C) | |||||||||||||
M_ala_057 | 1, 2, 3 | PYR | 1, 2, 3 | 0.7771 | 0.0586 | 0.0285 | 0.1358 | ||||||
M_ala_085 | 2, 3 | PYR | 2, 3 | 0.8027 | 0.0475 | 0.1497 | |||||||
M_asx_057 | 1, 2, 3, 4 | OAA | 1, 2, 3, 4 | 0.6223 | 0.1759 | 0.1167 | 0.0677 | 0.0173 | |||||
M_asx_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.6698 | 0.1857 | 0.1123 | 0.0321 | ||||||
M_asx_302 | 1, 2 | OAA | 1, 2 | 0.7723 | 0.1108 | 0.1169 | |||||||
M_glx_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.5469 | 0.1780 | 0.1864 | 0.0622 | 0.0207 | 0.0059 | ||||
M_glx_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.5910 | 0.1856 | 0.1753 | 0.0357 | 0.0124 | |||||
M_glx_302 | 1, 2 | AKG | 1, 2 | 0.7247 | 0.1880 | 0.0874 | |||||||
M_gly_057 | 1, 2 | 1, 2 | 0.8083 | 0.0612 | 0.1305 | ||||||||
M_gly_085 | 1 | 1 | 0.8354 | 0.1646 | |||||||||
M_his_057 | 1, 2, 3, 4, 5, 6 | R5P | 5, 4, 3, 2, 1 | 0.5227 | 0.1609 | 0.1080 | 0.1325 | 0.0357 | 0.0329 | 0.0073 | |||
M_his_159 | 2, 3, 4, 5, 6 | R5P | 4, 3, 2, 1 | 0.5169 | 0.1612 | 0.2063 | 0.0689 | 0.0355 | 0.0112 | ||||
M_his_302 | 1, 2 | R5P | 5, 4 | 0.7984 | 0.0361 | 0.1654 | |||||||
M_ile_015 | 1, 2, 3, 4, 5, 6 | OAA&PYR | 1,2,3,4&2,3 | 0.5165 | 0.1481 | 0.2009 | 0.0912 | 0.0432 | 0.0000 | 0.0000 | |||
M_ile_085 | 2, 3, 4, 5, 6 | OAA&PYR | 2,3,4&2,3 | 0.5553 | 0.1702 | 0.1861 | 0.0620 | 0.0202 | 0.0063 | ||||
M_leu_015 | 1, 2, 3, 4, 5, 6 | AcoA&PYR | 1,2&2,2,3,3 | 0.5395 | 0.0884 | 0.2743 | 0.0305 | 0.0650 | 0.0023 | 0.0000 | |||
M_leu_085 | 2, 3, 4, 5, 6 | AcoA&PYR | 2&2,2,3,3 | 0.5507 | 0.1606 | 0.2028 | 0.0551 | 0.0254 | 0.0054 | ||||
M_lys_057 | 1, 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 1,2,3,4&3,2/1,2,3&4,3,2 | 0.5194 | 0.1706 | 0.1497 | 0.0992 | 0.0416 | 0.0145 | 0.0049 | |||
M_lys_159 | 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 2,3,4&3,2/2,3& 4,3,2 | 0.5333 | 0.1854 | 0.1893 | 0.0636 | 0.0204 | 0.0080 | ||||
M_lys_302 | 1,2 | OAA/PYR | 1,2/1,2 | 0.6538 | 0.2656 | 0.0807 | |||||||
M_met_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.6959 | 0.2209 | 0.0353 | 0.0297 | 0.0137 | 0.0045 | ||||
M_met_085 | 2,3,4 | OAA | 2,3,4 | 0.7233 | 0.2133 | 0.0389 | 0.0216 | 0.0030 | |||||
M_phe_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.4987 | 0.1004 | 0.0907 | 0.1524 | 0.0706 | 0.0388 | 0.0302 | 0.0125 | 0.0032 | 0.0026 |
M_phe_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.5004 | 0.0965 | 0.1771 | 0.0872 | 0.0709 | 0.0361 | 0.0240 | 0.0046 | 0.0031 | |
M_phe_302 | 1, 2 | PEP | 1, 2 | 0.8280 | 0.0179 | 0.1541 | |||||||
M_phe_sc | 3,4,5,6,7,8,9 | PEP&E4P | 3,2,3&1,2,3,4 | 0.3803 | 0.1470 | 0.1487 | 0.0851 | 0.1094 | 0.0456 | 0.0586 | 0.0252 | ||
M_pro_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.5628 | 0.1626 | 0.1632 | 0.0812 | 0.0226 | 0.0076 | ||||
M_pro_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.6054 | 0.1808 | 0.1667 | 0.0343 | 0.0127 | |||||
M_ser_057 | 1, 2, 3 | 1, 2, 3 | 0.7811 | 0.0469 | 0.0218 | 0.1502 | |||||||
M_ser_085 | 2, 3 | 2, 3 | 0.7845 | 0.0653 | 0.1501 | ||||||||
M_ser_302 | 1, 2 | 1, 2 | 0.8107 | 0.0185 | 0.1708 | ||||||||
M_thr_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.6021 | 0.1815 | 0.1296 | 0.0636 | 0.0233 | |||||
M_thr_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.6554 | 0.1878 | 0.1305 | 0.0262 | ||||||
M_thr_sc | 3,4 | OAA | 3,4 | 0.6432 | 0.2531 | 0.1037 | |||||||
M_val_057 | 1, 2, 3, 4, 5 | PYR | 1, 2, 2, 3, 3 | 0.6424 | 0.0767 | 0.1348 | 0.1113 | 0.0118 | 0.0229 | ||||
M_val_085 | 2, 3, 4, 5 | PYR | 2, 2, 3, 3 | 0.6590 | 0.0690 | 0.2307 | 0.0153 | 0.0260 | |||||
M_val_302 | 1, 2 | PYR | 1, 2 | 0.7932 | 0.0604 | 0.1464 | |||||||
M_tyr_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.4878 | 0.1020 | 0.1013 | 0.1531 | 0.0730 | 0.0398 | 0.0269 | 0.0128 | 0.0032 | 0.0000 |
M_tyr_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.4889 | 0.1005 | 0.1861 | 0.0923 | 0.0695 | 0.0325 | 0.0252 | 0.0037 | 0.0014 | |
M_tyr_302 | 1, 2 | PEP | 1, 2 | 0.8181 | 0.0223 | 0.1596 | |||||||
Fe (U-13C) | |||||||||||||
M_ala_057 | 1, 2, 3 | PYR | 1, 2, 3 | 0.6653 | 0.0687 | 0.0481 | 0.2180 | ||||||
M_ala_085 | 2, 3 | PYR | 2, 3 | 0.7027 | 0.0516 | 0.2457 | |||||||
M_asx_057 | 1, 2, 3, 4 | OAA | 1, 2, 3, 4 | 0.5139 | 0.1980 | 0.0784 | 0.1563 | 0.0534 | |||||
M_asx_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.5856 | 0.1580 | 0.1399 | 0.1165 | ||||||
M_asx_302 | 1, 2 | OAA | 1, 2 | 0.6452 | 0.1865 | 0.1683 | |||||||
M_glx_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.4265 | 0.1428 | 0.2328 | 0.1277 | 0.0408 | 0.0294 | ||||
M_glx_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.4863 | 0.1174 | 0.3028 | 0.0394 | 0.0541 | |||||
M_glx_302 | 1, 2 | AKG | 1, 2 | 0.6145 | 0.2689 | 0.1166 | |||||||
M_gly_057 | 1, 2 | 1, 2 | 0.7073 | 0.1256 | 0.1672 | ||||||||
M_gly_085 | 1 | 1 | 0.7732 | 0.2268 | |||||||||
M_his_057 | 1, 2, 3, 4, 5, 6 | R5P | 5, 4, 3, 2, 1 | 0.5227 | 0.1609 | 0.1080 | 0.1325 | 0.0357 | 0.0329 | 0.0073 | |||
M_his_159 | 2, 3, 4, 5, 6 | R5P | 4, 3, 2, 1 | 0.5169 | 0.1612 | 0.2063 | 0.0689 | 0.0355 | 0.0112 | ||||
M_his_302 | 1, 2 | R5P | 5, 4 | 0.7984 | 0.0361 | 0.1654 | |||||||
M_ile_015 | 1, 2, 3, 4, 5, 6 | OAA&PYR | 1,2,3,4&2,3 | 0.3812 | 0.1562 | 0.1741 | 0.1614 | 0.0538 | 0.0524 | 0.0208 | |||
M_ile_085 | 2, 3, 4, 5, 6 | OAA&PYR | 2,3,4&2,3 | 0.4351 | 0.1340 | 0.2355 | 0.1232 | 0.0412 | 0.0311 | ||||
M_leu_015 | 1, 2, 3, 4, 5, 6 | AcoA&PYR | 1,2&2,2,3,3 | 0.3875 | 0.0690 | 0.3376 | 0.0590 | 0.1262 | 0.0072 | 0.0134 | |||
M_leu_085 | 2, 3, 4, 5, 6 | AcoA&PYR | 2&2,2,3,3 | 0.3941 | 0.1712 | 0.2546 | 0.1107 | 0.0524 | 0.0169 | ||||
M_lys_057 | 1, 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 1,2,3,4&3,2/1,2,3&4,3,2 | 0.3937 | 0.1582 | 0.1451 | 0.1789 | 0.0628 | 0.0405 | 0.0209 | |||
M_lys_159 | 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 2,3,4&3,2/2,3& 4,3,2 | 0.4262 | 0.1373 | 0.2278 | 0.1236 | 0.0429 | 0.0421 | ||||
M_lys_302 | 1,2 | OAA/PYR | 1,2/1,2 | 0.5390 | 0.3428 | 0.1181 | |||||||
M_met_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.3944 | 0.2637 | 0.1093 | 0.1351 | 0.0809 | 0.0167 | ||||
M_met_085 | 2,3,4 | OAA | 2,3,4 | 0.4615 | 0.2480 | 0.1384 | 0.1233 | 0.0288 | |||||
M_phe_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.3504 | 0.0882 | 0.1024 | 0.1830 | 0.0992 | 0.0689 | 0.0587 | 0.0279 | 0.0108 | 0.0106 |
M_phe_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.3535 | 0.0849 | 0.2022 | 0.1126 | 0.1116 | 0.0599 | 0.0527 | 0.0115 | 0.0110 | |
M_phe_302 | 1, 2 | PEP | 1, 2 | 0.7337 | 0.0211 | 0.2451 | |||||||
M_phe_sc | 3,4,5,6,7,8,9 | PEP&E4P | 3,2,3&1,2,3,4 | 0.2751 | 0.1470 | 0.1734 | 0.1093 | 0.1352 | 0.0607 | 0.0709 | 0.0284 | ||
M_pro_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.5409 | 0.1403 | 0.1547 | 0.1071 | 0.0337 | 0.0233 | ||||
M_pro_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.5292 | 0.0996 | 0.2819 | 0.0382 | 0.0511 | |||||
M_ser_057 | 1, 2, 3 | 1, 2, 3 | 0.6402 | 0.1096 | 0.0697 | 0.1805 | |||||||
M_ser_085 | 2, 3 | 2, 3 | 0.6570 | 0.1600 | 0.1830 | ||||||||
M_ser_302 | 1, 2 | 1, 2 | 0.7130 | 0.0548 | 0.2321 | ||||||||
M_thr_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.5067 | 0.1940 | 0.0814 | 0.1609 | 0.0571 | |||||
M_thr_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.5781 | 0.1512 | 0.1539 | 0.1168 | ||||||
M_thr_sc | 3,4 | OAA | 3,4 | 0.5460 | 0.2992 | 0.1549 | |||||||
M_val_057 | 1, 2, 3, 4, 5 | PYR | 1, 2, 2, 3, 3 | 0.5007 | 0.0748 | 0.1878 | 0.1625 | 0.0208 | 0.0535 | ||||
M_val_085 | 2, 3, 4, 5 | PYR | 2, 2, 3, 3 | 0.5210 | 0.0661 | 0.3278 | 0.0241 | 0.0611 | |||||
M_val_302 | 1, 2 | PYR | 1, 2 | 0.6948 | 0.0725 | 0.2327 | |||||||
M_tyr_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.3363 | 0.0843 | 0.1144 | 0.1806 | 0.1059 | 0.0691 | 0.0615 | 0.0273 | 0.0104 | 0.0102 |
M_tyr_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.3358 | 0.0837 | 0.2071 | 0.1196 | 0.1076 | 0.0653 | 0.0558 | 0.0121 | 0.0131 | |
M_tyr_302 | 1, 2 | PEP | 1, 2 | 0.7298 | 0.0199 | 0.2504 | |||||||
延胡索酸 Fumarate(U-13C) | |||||||||||||
M_ala_057 | 1, 2, 3 | PYR | 1, 2, 3 | 0.7549 | 0.0769 | 0.0532 | 0.1149 | ||||||
M_ala_085 | 2, 3 | PYR | 2, 3 | 0.8079 | 0.0369 | 0.1553 | |||||||
M_asx_057 | 1, 2, 3, 4 | OAA | 1, 2, 3, 4 | 0.8566 | 0.0824 | 0.0227 | 0.0326 | 0.0057 | |||||
M_asx_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.8834 | 0.0649 | 0.0371 | 0.0146 | ||||||
M_asx_302 | 1, 2 | OAA | 1, 2 | 0.9028 | 0.0649 | 0.0322 | |||||||
M_glx_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.7139 | 0.0853 | 0.1649 | 0.0262 | 0.0071 | 0.0027 | ||||
M_glx_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.7417 | 0.0774 | 0.1629 | 0.0098 | 0.0083 | |||||
M_glx_302 | 1, 2 | AKG | 1, 2 | 0.8524 | 0.1177 | 0.0300 | |||||||
M_gly_057 | 1, 2 | 1, 2 | 0.8221 | 0.0534 | 0.1245 | ||||||||
M_gly_085 | 1 | 1 | 0.8500 | 0.1500 | |||||||||
M_his_057 | 1, 2, 3, 4, 5, 6 | R5P | 5, 4, 3, 2, 1 | 0.5227 | 0.1609 | 0.1080 | 0.1325 | 0.0357 | 0.0329 | 0.0073 | |||
M_his_159 | 2, 3, 4, 5, 6 | R5P | 4, 3, 2, 1 | 0.5169 | 0.1612 | 0.2063 | 0.0689 | 0.0355 | 0.0112 | ||||
M_his_302 | 1, 2 | R5P | 5, 4 | 0.7984 | 0.0361 | 0.1654 | |||||||
M_ile_015 | 1, 2, 3, 4, 5, 6 | OAA&PYR | 1,2,3,4&2,3 | 0.6803 | 0.1019 | 0.1614 | 0.0377 | 0.0149 | 0.0038 | 0.0000 | |||
M_ile_085 | 2, 3, 4, 5, 6 | OAA&PYR | 2,3,4&2,3 | 0.6985 | 0.0910 | 0.1743 | 0.0255 | 0.0079 | 0.0027 | ||||
M_leu_015 | 1, 2, 3, 4, 5, 6 | AcoA&PYR | 1,2&2,2,3,3 | 0.5413 | 0.0739 | 0.2895 | 0.0299 | 0.0604 | 0.0006 | 0.0045 | |||
M_leu_085 | 2, 3, 4, 5, 6 | AcoA&PYR | 2&2,2,3,3 | 0.5449 | 0.1569 | 0.2142 | 0.0551 | 0.0240 | 0.0048 | ||||
M_lys_057 | 1, 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 1,2,3,4&3,2/1,2,3&4,3,2 | 0.6674 | 0.1133 | 0.1150 | 0.0846 | 0.0119 | 0.0062 | 0.0016 | |||
M_lys_159 | 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 2,3,4&3,2/2,3&4,3,2 | 0.6967 | 0.0906 | 0.1707 | 0.0279 | 0.0100 | 0.0040 | ||||
M_lys_302 | 1,2 | OAA/PYR | 1,2/1,2 | 0.7318 | 0.2435 | 0.0247 | |||||||
M_met_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.6959 | 0.2209 | 0.0353 | 0.0297 | 0.0137 | 0.0045 | ||||
M_met_085 | 2,3,4 | OAA | 2,3,4 | 0.7233 | 0.2133 | 0.0389 | 0.0216 | 0.0030 | |||||
M_phe_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.4690 | 0.1018 | 0.1024 | 0.1654 | 0.0744 | 0.0383 | 0.0293 | 0.0131 | 0.0033 | 0.0030 |
M_phe_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.4716 | 0.1001 | 0.1908 | 0.0929 | 0.0788 | 0.0329 | 0.0263 | 0.0036 | 0.0029 | |
M_phe_302 | 1, 2 | PEP | 1, 2 | 0.8166 | 0.0181 | 0.1653 | |||||||
M_phe_sc | 3,4,5,6,7,8,9 | PEP&E4P | 3,2,3&1,2,3,4 | 0.3993 | 0.1696 | 0.1489 | 0.0949 | 0.0984 | 0.0384 | 0.0504 | |||
M_pro_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.6515 | 0.0727 | 0.1395 | 0.1168 | 0.0162 | 0.0033 | ||||
M_pro_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.7504 | 0.0787 | 0.1576 | 0.0060 | 0.0073 | |||||
M_ser_057 | 1, 2, 3 | 1, 2, 3 | 0.7535 | 0.0701 | 0.0430 | 0.1334 | |||||||
M_ser_085 | 2, 3 | 2, 3 | 0.7630 | 0.1045 | 0.1325 | ||||||||
M_ser_302 | 1, 2 | 1, 2 | 0.7998 | 0.0287 | 0.1715 | ||||||||
M_thr_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.8495 | 0.0858 | 0.0229 | 0.0346 | 0.0072 | |||||
M_thr_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.8791 | 0.0609 | 0.0440 | 0.0160 | ||||||
M_thr_sc | 3,4 | OAA | 3,4 | 0.7799 | 0.1869 | 0.0332 | |||||||
M_val_057 | 1, 2, 3, 4, 5 | PYR | 1, 2, 2, 3, 3 | 0.6138 | 0.0911 | 0.1594 | 0.1045 | 0.0120 | 0.0193 | ||||
M_val_085 | 2, 3, 4, 5 | PYR | 2, 2, 3, 3 | 0.6486 | 0.0641 | 0.2490 | 0.0122 | 0.0261 | |||||
M_val_302 | 1, 2 | PYR | 1, 2 | 0.7650 | 0.0993 | 0.1357 | |||||||
M_tyr_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.4588 | 0.1002 | 0.1068 | 0.1695 | 0.0761 | 0.0369 | 0.0308 | 0.0138 | 0.0029 | 0.0043 |
M_tyr_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.4680 | 0.0996 | 0.1933 | 0.0916 | 0.0816 | 0.0338 | 0.0243 | 0.0042 | 0.0037 | |
M_tyr_302 | 1, 2 | PEP | 1, 2 | 0.8064 | 0.0214 | 0.1722 | |||||||
DMSO(U-13C) | |||||||||||||
M_ala_057 | 1, 2, 3 | PYR | 1, 2, 3 | 0.7596 | 0.0505 | 0.0361 | 0.1538 | ||||||
M_ala_085 | 2, 3 | PYR | 2, 3 | 0.7778 | 0.0509 | 0.1713 | |||||||
M_asx_057 | 1, 2, 3, 4 | OAA | 1, 2, 3, 4 | 0.6192 | 0.1729 | 0.0738 | 0.1092 | 0.0249 | |||||
M_asx_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.6709 | 0.1582 | 0.1114 | 0.0596 | ||||||
M_asx_302 | 1, 2 | OAA | 1, 2 | 0.7382 | 0.1339 | 0.1279 | |||||||
M_glx_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.5272 | 0.1559 | 0.2052 | 0.0792 | 0.0224 | 0.0102 | ||||
M_glx_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.5823 | 0.1361 | 0.2267 | 0.0291 | 0.0258 | |||||
M_glx_302 | 1, 2 | AKG | 1, 2 | 0.6949 | 0.2244 | 0.0807 | |||||||
M_gly_057 | 1, 2 | 1, 2 | 0.7738 | 0.0761 | 0.1501 | ||||||||
M_gly_085 | 1 | 1 | 0.8112 | 0.1888 | |||||||||
M_his_057 | 1, 2, 3, 4, 5, 6 | R5P | 5, 4, 3, 2, 1 | 0.5227 | 0.1609 | 0.1080 | 0.1325 | 0.0357 | 0.0329 | 0.0073 | |||
M_his_159 | 2, 3, 4, 5, 6 | R5P | 4, 3, 2, 1 | 0.5169 | 0.1612 | 0.2063 | 0.0689 | 0.0355 | 0.0112 | ||||
M_his_302 | 1, 2 | R5P | 5, 4 | 0.7984 | 0.0361 | 0.1654 | |||||||
M_ile_015 | 1, 2, 3, 4, 5, 6 | OAA&PYR | 1,2,3,4&2,3 | 0.5000 | 0.1680 | 0.1581 | 0.1163 | 0.0465 | 0.0112 | 0.0000 | |||
M_ile_085 | 2, 3, 4, 5, 6 | OAA&PYR | 2,3,4&2,3 | 0.5293 | 0.1528 | 0.2062 | 0.0789 | 0.0209 | 0.0119 | ||||
M_leu_015 | 1, 2, 3, 4, 5, 6 | AcoA&PYR | 1,2&2,2,3,3 | 0.4933 | 0.1014 | 0.3028 | 0.0354 | 0.0606 | 0.0064 | 0.0000 | |||
M_leu_085 | 2, 3, 4, 5, 6 | AcoA&PYR | 2&2,2,3,3 | 0.5086 | 0.1741 | 0.2230 | 0.0623 | 0.0258 | 0.0061 | ||||
M_lys_057 | 1, 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 1,2,3,4&3,2/1,2,3&4,3,2 | 0.5194 | 0.1706 | 0.1497 | 0.0992 | 0.0416 | 0.0145 | 0.0049 | |||
M_lys_159 | 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 2,3,4&3,2/2,3& 4,3,2 | 0.5333 | 0.1854 | 0.1893 | 0.0636 | 0.0204 | 0.0080 | ||||
M_lys_302 | 1,2 | OAA/PYR | 1,2/1,2 | 0.6538 | 0.2656 | 0.0807 | |||||||
M_met_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.5209 | 0.2351 | 0.0858 | 0.1153 | 0.0357 | 0.0073 | ||||
M_met_085 | 2,3,4 | OAA | 2,3,4 | 0.5631 | 0.2369 | 0.1186 | 0.0545 | 0.0269 | |||||
M_phe_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3& 1, 2, 3, 4 | 0.4415 | 0.1047 | 0.1088 | 0.1722 | 0.0743 | 0.0451 | 0.0320 | 0.0133 | 0.0049 | 0.0032 |
M_phe_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.4505 | 0.1030 | 0.1953 | 0.1010 | 0.0781 | 0.0390 | 0.0256 | 0.0044 | 0.0032 | |
M_phe_302 | 1, 2 | PEP | 1, 2 | 0.8022 | 0.0251 | 0.1727 | |||||||
M_phe_sc | 3,4,5,6,7,8,9 | PEP&E4P | 3,2,3&1,2,3,4 | 0.3191 | 0.1447 | 0.1799 | 0.0898 | 0.1191 | 0.0467 | 0.0694 | 0.0313 | ||
M_pro_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.6670 | 0.1257 | 0.0716 | 0.0936 | 0.0306 | 0.0115 | ||||
M_pro_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.6131 | 0.1116 | 0.2324 | 0.0130 | 0.0299 | |||||
M_ser_057 | 1, 2, 3 | 1, 2, 3 | 0.7470 | 0.0797 | 0.0484 | 0.1249 | |||||||
M_ser_085 | 2, 3 | 2, 3 | 0.7718 | 0.1342 | 0.0940 | ||||||||
M_ser_302 | 1, 2 | 1, 2 | 0.7695 | 0.0896 | 0.1410 | ||||||||
M_thr_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.6153 | 0.1799 | 0.0688 | 0.1098 | 0.0262 | |||||
M_thr_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.6649 | 0.1601 | 0.1175 | 0.0575 | ||||||
M_thr_sc | 3,4 | OAA | 3,4 | 0.6324 | 0.2705 | 0.0970 | |||||||
M_val_057 | 1, 2, 3, 4, 5 | PYR | 1, 2, 2, 3, 3 | 0.6111 | 0.0749 | 0.1489 | 0.1245 | 0.0132 | 0.0274 | ||||
M_val_085 | 2, 3, 4, 5 | PYR | 2, 2, 3, 3 | 0.6224 | 0.0756 | 0.2601 | 0.0144 | 0.0274 | |||||
M_val_302 | 1, 2 | PYR | 1, 2 | 0.7795 | 0.0448 | 0.1757 | |||||||
M_tyr_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3& 1, 2, 3, 4 | 0.4346 | 0.1068 | 0.1137 | 0.1947 | 0.0657 | 0.0496 | 0.0234 | 0.0107 | 0.0000 | 0.0008 |
M_tyr_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.4182 | 0.0981 | 0.1878 | 0.1259 | 0.0942 | 0.0459 | 0.0287 | 0.0000 | 0.0013 | |
M_tyr_302 | 1, 2 | PEP | 1, 2 | 0.7929 | 0.0251 | 0.1821 | |||||||
硝酸盐 Nitrate(1-13C) | |||||||||||||
M_ala_057 | 1, 2, 3 | PYR | 1, 2, 3 | 0.5398 | 0.4523 | 0.0079 | 0.0000 | ||||||
M_ala_085 | 2, 3 | PYR | 2, 3 | 0.9793 | 0.0207 | 0.0000 | |||||||
M_asx_057 | 1, 2, 3, 4 | OAA | 1, 2, 3, 4 | 0.7515 | 0.1998 | 0.0485 | 0.0000 | 0.0002 | |||||
M_asx_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.8524 | 0.1461 | 0.0015 | 0.0000 | ||||||
M_asx_302 | 1, 2 | OAA | 1, 2 | 0.8451 | 0.1546 | 0.0003 | |||||||
M_glx_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.8287 | 0.1641 | 0.0068 | 0.0000 | 0.0003 | 0.0000 | ||||
M_glx_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.9262 | 0.0711 | 0.0020 | 0.0004 | 0.0004 | |||||
M_glx_302 | 1, 2 | AKG | 1, 2 | 0.8445 | 0.1554 | 0.0000 | |||||||
M_gly_057 | 1, 2 | 1, 2 | 0.8995 | 0.0979 | 0.0026 | ||||||||
M_gly_085 | 1 | 1 | 0.9867 | 0.0133 | |||||||||
M_his_057 | 1, 2, 3, 4, 5, 6 | R5P | 5, 4, 3, 2, 1 | 0.4425 | 0.4269 | 0.1183 | 0.0116 | 0.0002 | 0.0005 | 0.0000 | |||
M_his_159 | 2, 3, 4, 5, 6 | R5P | 4, 3, 2, 1 | 0.4720 | 0.4370 | 0.0742 | 0.0107 | 0.0044 | 0.0017 | ||||
M_his_302 | 1, 2 | R5P | 5, 4 | 0.8912 | 0.1088 | 0.0000 | |||||||
M_ile_015 | 1, 2, 3, 4, 5, 6 | OAA&PYR | 1,2,3,4&2,3 | 0.7233 | 0.2029 | 0.0583 | 0.0103 | 0.0041 | 0.0011 | 0.0000 | |||
M_ile_085 | 2, 3, 4, 5, 6 | OAA&PYR | 2,3,4&2,3 | 0.8226 | 0.1686 | 0.0083 | 0.0002 | 0.0002 | 0.0002 | ||||
M_leu_015 | 1, 2, 3, 4, 5, 6 | AcoA&PYR | 1,2&2,2,3,3 | 0.9312 | 0.0618 | 0.0010 | 0.0054 | 0.0005 | 0.0000 | 0.0001 | |||
M_leu_085 | 2, 3, 4, 5, 6 | AcoA&PYR | 2&2,2,3,3 | 0.9350 | 0.0645 | 0.0003 | 0.0002 | 0.0001 | 0.0000 | ||||
M_lys_057 | 1, 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 1,2,3,4&3,2/1,2,3&4,3,2 | 0.4759 | 0.3053 | 0.1717 | 0.0000 | 0.0246 | 0.0083 | 0.0142 | |||
M_lys_159 | 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 2,3,4&3,2/2,3& 4,3,2 | 0.2194 | 0.0498 | 0.1072 | 0.1872 | 0.3795 | 0.0569 | ||||
M_lys_302 | 1,2 | OAA/PYR | 1,2/1,2 | 0.6946 | 0.2732 | 0.0322 | |||||||
M_met_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.7313 | 0.2028 | 0.0503 | 0.0086 | 0.0027 | 0.0042 | ||||
M_met_085 | 2,3,4 | OAA | 2,3,4 | 0.8263 | 0.1619 | 0.0072 | 0.0032 | 0.0014 | |||||
M_phe_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.8884 | 0.1044 | 0.0041 | 0.0009 | 0.0001 | 0.0007 | 0.0005 | 0.0005 | 0.0003 | 0.0002 |
M_phe_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.8961 | 0.0939 | 0.0041 | 0.0018 | 0.0006 | 0.0008 | 0.0007 | 0.0015 | 0.0004 | |
M_phe_302 | 1, 2 | PEP | 1, 2 | 0.9771 | 0.0229 | 0.0000 | |||||||
M_phe_sc | 3,4,5,6,7,8,9 | PEP&E4P | 3,2,3&1,2,3,4 | 0.7523 | 0.0947 | 0.0332 | 0.0085 | 0.0215 | 0.0207 | 0.0405 | 0.0286 | ||
M_pro_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.8748 | 0.1149 | 0.0000 | 0.0042 | 0.0045 | 0.0016 | ||||
M_pro_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.9366 | 0.0612 | 0.0011 | 0.0000 | 0.0010 | |||||
M_ser_057 | 1, 2, 3 | 1, 2, 3 | 0.9605 | 0.0391 | 0.0000 | 0.0004 | |||||||
M_ser_085 | 2, 3 | 2, 3 | 0.9810 | 0.0190 | 0.0000 | ||||||||
M_ser_302 | 1, 2 | 1, 2 | 0.9667 | 0.0304 | 0.0029 | ||||||||
M_thr_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.7489 | 0.1979 | 0.0517 | 0.0007 | 0.0008 | |||||
M_thr_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.8435 | 0.1479 | 0.0086 | 0.0000 | ||||||
M_thr_sc | 3,4 | OAA | 3,4 | 0.7463 | 0.2252 | 0.0285 | |||||||
M_val_057 | 1, 2, 3, 4, 5 | PYR | 1, 2, 2, 3, 3 | 0.5218 | 0.4572 | 0.0200 | 0.0009 | 0.0000 | 0.0000 | ||||
M_val_085 | 2, 3, 4, 5 | PYR | 2, 2, 3, 3 | 0.9458 | 0.0511 | 0.0027 | 0.0003 | 0.0002 | |||||
M_val_302 | 1, 2 | PYR | 1, 2 | 0.5866 | 0.4116 | 0.0018 | |||||||
M_tyr_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.8800 | 0.1030 | 0.0044 | 0.0000 | 0.0011 | 0.0004 | 0.0006 | 0.0006 | 0.0031 | 0.0068 |
M_tyr_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.8890 | 0.0969 | 0.0014 | 0.0011 | 0.0011 | 0.0014 | 0.0002 | 0.0047 | 0.0042 | |
M_tyr_302 | 1, 2 | PEP | 1, 2 | 0.9779 | 0.0220 | 0.0001 | |||||||
Fe (1-13C) | |||||||||||||
M_ala_057 | 1, 2, 3 | PYR | 1, 2, 3 | 0.5273 | 0.4640 | 0.0088 | 0.0000 | ||||||
M_ala_085 | 2, 3 | PYR | 2, 3 | 0.9764 | 0.0230 | 0.0006 | |||||||
M_asx_057 | 1, 2, 3, 4 | OAA | 1, 2, 3, 4 | 0.3476 | 0.4571 | 0.1910 | 0.0043 | 0.0000 | |||||
M_asx_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.5600 | 0.4314 | 0.0086 | 0.0000 | ||||||
M_asx_302 | 1, 2 | OAA | 1, 2 | 0.5890 | 0.4087 | 0.0023 | |||||||
M_glx_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.5616 | 0.4186 | 0.0195 | 0.0002 | 0.0000 | 0.0000 | ||||
M_glx_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.8990 | 0.0986 | 0.0020 | 0.0000 | 0.0004 | |||||
M_glx_302 | 1, 2 | AKG | 1, 2 | 0.6891 | 0.3048 | 0.0062 | |||||||
M_gly_057 | 1, 2 | 1, 2 | 0.7664 | 0.2334 | 0.0002 | ||||||||
M_gly_085 | 1 | 1 | 0.9934 | 0.0066 | |||||||||
M_his_057 | 1, 2, 3, 4, 5, 6 | R5P | 5, 4, 3, 2, 1 | 0.4425 | 0.4269 | 0.1183 | 0.0116 | 0.0002 | 0.0005 | 0.0000 | |||
M_his_159 | 2, 3, 4, 5, 6 | R5P | 4, 3, 2, 1 | 0.4720 | 0.4370 | 0.0742 | 0.0107 | 0.0044 | 0.0017 | ||||
M_his_302 | 1, 2 | R5P | 5, 4 | 0.8912 | 0.1088 | 0.0000 | |||||||
M_ile_015 | 1, 2, 3, 4, 5, 6 | OAA&PYR | 1,2,3,4&2,3 | 0.3508 | 0.4485 | 0.1854 | 0.0134 | 0.0019 | 0.0000 | 0.0000 | |||
M_ile_085 | 2, 3, 4, 5, 6 | OAA&PYR | 2,3,4&2,3 | 0.5499 | 0.4265 | 0.0229 | 0.0000 | 0.0007 | 0.0000 | ||||
M_leu_015 | 1, 2, 3, 4, 5, 6 | AcoA&PYR | 1,2&2,2,3,3 | 0.9468 | 0.0484 | 0.0017 | 0.0029 | 0.0000 | 0.0000 | 0.0002 | |||
M_leu_085 | 2, 3, 4, 5, 6 | AcoA&PYR | 2&2,2,3,3 | 0.9339 | 0.0657 | 0.0001 | 0.0001 | 0.0002 | 0.0000 | ||||
M_lys_057 | 1, 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 1,2,3,4&3,2/ 1,2,3&4,3,2 | 0.3053 | 0.4567 | 0.2213 | 0.0123 | 0.0005 | 0.0025 | 0.0014 | |||
M_lys_159 | 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 2,3,4&3,2/2,3& 4,3,2 | 0.4979 | 0.4162 | 0.0247 | 0.0080 | 0.0057 | 0.0474 | ||||
M_lys_302 | 1,2 | OAA/PYR | 1,2/1,2 | 0.8733 | 0.1267 | 0.0000 | |||||||
M_met_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.3424 | 0.4536 | 0.1957 | 0.0079 | 0.0000 | 0.0004 | ||||
M_met_085 | 2,3,4 | OAA | 2,3,4 | 0.5530 | 0.4297 | 0.0165 | 0.0000 | 0.0008 | |||||
M_phe_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3& 1, 2, 3, 4 | 0.8883 | 0.1064 | 0.0045 | 0.0000 | 0.0002 | 0.0001 | 0.0001 | 0.0002 | 0.0000 | 0.0000 |
M_phe_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.8976 | 0.0996 | 0.0021 | 0.0002 | 0.0000 | 0.0003 | 0.0001 | 0.0001 | 0.0000 | |
M_phe_302 | 1, 2 | PEP | 1, 2 | 0.9859 | 0.0141 | 0.0000 | |||||||
M_phe_sc | 3,4,5,6,7,8,9 | PEP&E4P | 3,2,3&1,2,3,4 | 0.7505 | 0.0973 | 0.0400 | 0.0097 | 0.0295 | 0.0126 | 0.0372 | 0.0232 | ||
M_pro_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.6058 | 0.3772 | 0.0109 | 0.0043 | 0.0011 | 0.0008 | ||||
M_pro_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.8992 | 0.0964 | 0.0039 | 0.0002 | 0.0004 | |||||
M_ser_057 | 1, 2, 3 | 1, 2, 3 | 0.9242 | 0.0736 | 0.0021 | 0.0000 | |||||||
M_ser_085 | 2, 3 | 2, 3 | 0.9848 | 0.0152 | 0.0000 | ||||||||
M_ser_302 | 1, 2 | 1, 2 | 0.9275 | 0.0696 | 0.0029 | ||||||||
M_thr_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.3373 | 0.4592 | 0.2014 | 0.0021 | 0.0000 | |||||
M_thr_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.5589 | 0.4272 | 0.0135 | 0.0004 | ||||||
M_thr_sc | 3,4 | OAA | 3,4 | 0.5019 | 0.4845 | 0.0136 | |||||||
M_val_057 | 1, 2, 3, 4, 5 | PYR | 1, 2, 2, 3, 3 | 0.5165 | 0.4582 | 0.0251 | 0.0000 | 0.0000 | 0.0002 | ||||
M_val_085 | 2, 3, 4, 5 | PYR | 2, 2, 3, 3 | 0.9413 | 0.0551 | 0.0033 | 0.0000 | 0.0003 | |||||
M_val_302 | 1, 2 | PYR | 1, 2 | 0.5793 | 0.4195 | 0.0012 | |||||||
M_tyr_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.8856 | 0.1102 | 0.0031 | 0.0000 | 0.0005 | 0.0005 | 0.0000 | 0.0000 | 0.0000 | 0.0000 |
M_tyr_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.8974 | 0.0979 | 0.0021 | 0.0018 | 0.0000 | 0.0005 | 0.0002 | 0.0000 | 0.0000 | |
M_tyr_302 | 1, 2 | PEP | 1, 2 | 0.9857 | 0.0143 | 0.0000 | |||||||
延胡索酸 Fumarate (1-13C) | |||||||||||||
M_ala_057 | 1, 2, 3 | PYR | 1, 2, 3 | 0.5836 | 0.4087 | 0.0077 | 0.0000 | ||||||
M_ala_085 | 2, 3 | PYR | 2, 3 | 0.9776 | 0.0224 | 0.0000 | |||||||
M_asx_057 | 1, 2, 3, 4 | OAA | 1, 2, 3, 4 | 0.9250 | 0.0653 | 0.0090 | 0.0000 | 0.0008 | |||||
M_asx_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.9468 | 0.0532 | 0.0000 | 0.0000 | ||||||
M_asx_302 | 1, 2 | OAA | 1, 2 | 0.9549 | 0.0441 | 0.0009 | |||||||
M_glx_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.9232 | 0.0758 | 0.0000 | 0.0009 | 0.0000 | 0.0001 | ||||
M_glx_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.9509 | 0.0490 | 0.0000 | 0.0000 | 0.0000 | |||||
M_glx_302 | 1, 2 | AKG | 1, 2 | 0.9143 | 0.0857 | 0.0000 | |||||||
M_gly_057 | 1, 2 | 1, 2 | 0.8501 | 0.1485 | 0.0014 | ||||||||
M_gly_085 | 1 | 1 | 0.9928 | 0.0072 | |||||||||
M_his_057 | 1, 2, 3, 4, 5, 6 | R5P | 5, 4, 3, 2, 1 | 0.4425 | 0.4269 | 0.1183 | 0.0116 | 0.0002 | 0.0005 | 0.0000 | |||
M_his_159 | 2, 3, 4, 5, 6 | R5P | 4, 3, 2, 1 | 0.4720 | 0.4370 | 0.0742 | 0.0107 | 0.0044 | 0.0017 | ||||
M_his_302 | 1, 2 | R5P | 5, 4 | 0.8912 | 0.1088 | 0.0000 | |||||||
M_ile_015 | 1, 2, 3, 4, 5, 6 | OAA&PYR | 1,2,3,4&2,3 | 0.8896 | 0.0983 | 0.0109 | 0.0000 | 0.0009 | 0.0000 | 0.0003 | |||
M_ile_085 | 2, 3, 4, 5, 6 | OAA&PYR | 2,3,4&2,3 | 0.9197 | 0.0794 | 0.0003 | 0.0000 | 0.0005 | 0.0000 | ||||
M_leu_015 | 1, 2, 3, 4, 5, 6 | AcoA&PYR | 1,2&2,2,3,3 | 0.9294 | 0.0674 | 0.0030 | 0.0000 | 0.0000 | 0.0000 | 0.0002 | |||
M_leu_085 | 2, 3, 4, 5, 6 | AcoA&PYR | 2&2,2,3,3 | 0.9340 | 0.0657 | 0.0000 | 0.0000 | 0.0002 | 0.0001 | ||||
M_lys_057 | 1, 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 1,2,3,4&3,2/1,2,3&4,3,2 | 0.7096 | 0.2448 | 0.0374 | 0.0065 | 0.0000 | 0.0000 | 0.0017 | |||
M_lys_159 | 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 2,3,4&3,2/2,3& 4,3,2 | 0.8280 | 0.1000 | 0.0134 | 0.0026 | 0.0091 | 0.0469 | ||||
M_lys_302 | 1,2 | OAA/PYR | 1,2/1,2 | 0.8531 | 0.1469 | 0.0000 | |||||||
M_met_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.9177 | 0.0766 | 0.0000 | 0.0030 | 0.0014 | 0.0013 | ||||
M_met_085 | 2,3,4 | OAA | 2,3,4 | 0.9272 | 0.0717 | 0.0000 | 0.0000 | 0.0011 | |||||
M_phe_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.8943 | 0.0981 | 0.0068 | 0.0000 | 0.0000 | 0.0004 | 0.0001 | 0.0003 | 0.0000 | 0.0000 |
M_phe_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.8958 | 0.0995 | 0.0035 | 0.0002 | 0.0001 | 0.0005 | 0.0003 | 0.0001 | 0.0000 | |
M_phe_302 | 1, 2 | PEP | 1, 2 | 0.9865 | 0.0135 | 0.0000 | |||||||
M_phe_sc | 3,4,5,6,7,8,9 | PEP&E4P | 3,2,3&1,2,3,4 | 0.7512 | 0.0956 | 0.0420 | 0.0092 | 0.0288 | 0.0134 | 0.0346 | 0.0251 | ||
M_pro_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.7781 | 0.0692 | 0.0009 | 0.1459 | 0.0060 | 0.0000 | ||||
M_pro_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.9442 | 0.0556 | 0.0000 | 0.0000 | 0.0001 | |||||
M_ser_057 | 1, 2, 3 | 1, 2, 3 | 0.9120 | 0.0857 | 0.0023 | 0.0000 | |||||||
M_ser_085 | 2, 3 | 2, 3 | 0.9798 | 0.0202 | 0.0000 | ||||||||
M_ser_302 | 1, 2 | 1, 2 | 0.9211 | 0.0789 | 0.0000 | ||||||||
M_thr_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.9300 | 0.0609 | 0.0088 | 0.0000 | 0.0003 | |||||
M_thr_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.9517 | 0.0464 | 0.0019 | 0.0000 | ||||||
M_thr_sc | 3,4 | OAA | 3,4 | 0.8347 | 0.1521 | 0.0131 | |||||||
M_val_057 | 1, 2, 3, 4, 5 | PYR | 1, 2, 2, 3, 3 | 0.5676 | 0.4133 | 0.0184 | 0.0000 | 0.0006 | 0.0001 | ||||
M_val_085 | 2, 3, 4, 5 | PYR | 2, 2, 3, 3 | 0.9485 | 0.0511 | 0.0000 | 0.0001 | 0.0003 | |||||
M_val_302 | 1, 2 | PYR | 1, 2 | 0.6328 | 0.3672 | 0.0000 | |||||||
M_tyr_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.8977 | 0.1009 | 0.0000 | 0.0007 | 0.0006 | 0.0001 | 0.0000 | 0.0000 | 0.0000 | 0.0000 |
M_tyr_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.9080 | 0.0882 | 0.0002 | 0.0018 | 0.0016 | 0.0000 | 0.0000 | 0.0000 | 0.0001 | |
M_tyr_302 | 1, 2 | PEP | 1, 2 | 0.9834 | 0.0166 | 0.0000 | |||||||
DMSO (1-13C) | |||||||||||||
M_ala_057 | 1, 2, 3 | PYR | 1, 2, 3 | 0.5872 | 0.4050 | 0.0078 | 0.0000 | ||||||
M_ala_085 | 2, 3 | PYR | 2, 3 | 0.9792 | 0.0208 | 0.0000 | |||||||
M_asx_057 | 1, 2, 3, 4 | OAA | 1, 2, 3, 4 | 0.9336 | 0.0586 | 0.0075 | 0.0002 | 0.0000 | |||||
M_asx_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.9558 | 0.0440 | 0.0000 | 0.0002 | ||||||
M_asx_302 | 1, 2 | OAA | 1, 2 | 0.9664 | 0.0336 | 0.0000 | |||||||
M_glx_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.9268 | 0.0723 | 0.0000 | 0.0009 | 0.0000 | 0.0000 | ||||
M_glx_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.9477 | 0.0500 | 0.0000 | 0.0023 | 0.0000 | |||||
M_glx_302 | 1, 2 | AKG | 1, 2 | 0.8997 | 0.1003 | 0.0000 | |||||||
M_gly_057 | 1, 2 | 1, 2 | 0.8728 | 0.1263 | 0.0010 | ||||||||
M_gly_085 | 1 | 1 | 0.9910 | 0.0090 | |||||||||
M_his_057 | 1, 2, 3, 4, 5, 6 | R5P | 5, 4, 3, 2, 1 | 0.4425 | 0.4269 | 0.1183 | 0.0116 | 0.0002 | 0.0005 | 0.0000 | |||
M_his_159 | 2, 3, 4, 5, 6 | R5P | 4, 3, 2, 1 | 0.4720 | 0.4370 | 0.0742 | 0.0107 | 0.0044 | 0.0017 | ||||
M_his_302 | 1, 2 | R5P | 5, 4 | 0.8912 | 0.1088 | 0.0000 | |||||||
M_ile_015 | 1, 2, 3, 4, 5, 6 | OAA&PYR | 1,2,3,4&2,3 | 0.8904 | 0.0931 | 0.0158 | 0.0000 | 0.0000 | 0.0003 | 0.0003 | |||
M_ile_085 | 2, 3, 4, 5, 6 | OAA&PYR | 2,3,4&2,3 | 0.9199 | 0.0786 | 0.0011 | 0.0002 | 0.0002 | 0.0000 | ||||
M_leu_015 | 1, 2, 3, 4, 5, 6 | AcoA&PYR | 1,2&2,2,3,3 | 0.9369 | 0.0608 | 0.0000 | 0.0016 | 0.0005 | 0.0000 | 0.0002 | |||
M_leu_085 | 2, 3, 4, 5, 6 | AcoA&PYR | 2&2,2,3,3 | 0.9308 | 0.0688 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | ||||
M_lys_057 | 1, 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 1,2,3,4&3,2/1,2,3&4,3,2 | 0.7104 | 0.2644 | 0.0183 | 0.0053 | 0.0013 | 0.0002 | 0.0000 | |||
M_lys_159 | 2, 3, 4, 5, 6 | OAA&PYR/PYR&OAA | 2,3,4&3,2/2,3&4,3,2 | 0.8848 | 0.0838 | 0.0017 | 0.0073 | 0.0019 | 0.0205 | ||||
M_lys_302 | 1,2 | OAA/PYR | 1,2/1,2 | 0.8678 | 0.1322 | 0.0000 | |||||||
M_met_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.9140 | 0.0749 | 0.0080 | 0.0024 | 0.0000 | 0.0007 | ||||
M_met_085 | 2,3,4 | OAA | 2,3,4 | 0.9399 | 0.0595 | 0.0005 | 0.0000 | 0.0000 | |||||
M_phe_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.8961 | 0.0999 | 0.0018 | 0.0016 | 0.0000 | 0.0001 | 0.0003 | 0.0001 | 0.0000 | 0.0000 |
M_phe_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.8960 | 0.0987 | 0.0045 | 0.0000 | 0.0003 | 0.0002 | 0.0002 | 0.0001 | 0.0000 | |
M_phe_302 | 1, 2 | PEP | 1, 2 | 0.9835 | 0.0165 | 0.0000 | |||||||
M_phe_sc | 3,4,5,6,7,8,9 | PEP&E4P | 3,2,3&1,2,3,4 | 0.7579 | 0.1032 | 0.0376 | 0.0077 | 0.0256 | 0.0115 | 0.0368 | 0.0197 | ||
M_pro_057 | 1, 2, 3, 4, 5 | AKG | 1, 2, 3, 4, 5 | 0.6492 | 0.0545 | 0.0009 | 0.2896 | 0.0058 | 0.0000 | ||||
M_pro_085 | 2, 3, 4, 5 | AKG | 2, 3, 4, 5 | 0.9422 | 0.0553 | 0.0000 | 0.0024 | 0.0001 | |||||
M_ser_057 | 1, 2, 3 | 1, 2, 3 | 0.9195 | 0.0803 | 0.0000 | 0.0002 | |||||||
M_ser_085 | 2, 3 | 2, 3 | 0.9858 | 0.0142 | 0.0000 | ||||||||
M_ser_302 | 1, 2 | 1, 2 | 0.9235 | 0.0728 | 0.0036 | ||||||||
M_thr_057 | 1,2,3,4 | OAA | 1,2,3,4 | 0.9335 | 0.0616 | 0.0039 | 0.0004 | 0.0006 | |||||
M_thr_085 | 2, 3, 4 | OAA | 2, 3, 4 | 0.9571 | 0.0400 | 0.0000 | 0.0028 | ||||||
M_thr_sc | 3,4 | OAA | 3,4 | 0.8412 | 0.1503 | 0.0085 | |||||||
M_val_057 | 1, 2, 3, 4, 5 | PYR | 1, 2, 2, 3, 3 | 0.5633 | 0.4172 | 0.0193 | 0.0000 | 0.0000 | 0.0002 | ||||
M_val_085 | 2, 3, 4, 5 | PYR | 2, 2, 3, 3 | 0.9400 | 0.0552 | 0.0048 | 0.0000 | 0.0000 | |||||
M_val_302 | 1, 2 | PYR | 1, 2 | 0.6248 | 0.3687 | 0.0065 | |||||||
M_tyr_057 | 1, 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 1, 2, 3, 2, 3&1, 2, 3, 4 | 0.8903 | 0.1039 | 0.0056 | 0.0001 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 |
M_tyr_085 | 2, 3, 4, 5, 6, 7, 8, 9 | PEP&E4P | 2, 3, 2, 3&1, 2, 3, 4 | 0.8916 | 0.1056 | 0.0000 | 0.0005 | 0.0016 | 0.0007 | 0.0000 | 0.0000 | 0.0001 | |
M_tyr_302 | 1, 2 | PEP | 1, 2 | 0.9859 | 0.0141 | 0.0000 |
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