Synthetic Biology Journal ›› 2020, Vol. 1 ›› Issue (2): 187-211.DOI: 10.12211/2096-8280.2020-002
• Invited Review • Previous Articles Next Articles
HUANG Xuenian, TANG Shen, LV Xuefeng
Received:
2020-02-26
Revised:
2020-03-23
Online:
2020-08-04
Published:
2020-04-30
黄雪年, 唐慎, 吕雪峰
作者简介:
黄雪年(1986—),男,博士,副研究员,主要从事丝状真菌天然产物生物合成研究。E-mail:huangxn@qibebt.ac.cn基金资助:
CLC Number:
HUANG Xuenian, TANG Shen, LV Xuefeng. Progress and prospect for synthetic biology research of the industrial filamentous fungi Aspergillus terreus[J]. Synthetic Biology Journal, 2020, 1(2): 187-211.
黄雪年, 唐慎, 吕雪峰. 工业丝状真菌土曲霉合成生物技术研究进展及展望[J]. 合成生物学, 2020, 1(2): 187-211.
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URL: https://synbioj.cip.com.cn/EN/10.12211/2096-8280.2020-002
序号 | 核心基因编号 | 类型 | 代表性产物 | 参考文献 |
---|---|---|---|---|
1 | ATEG_00145 (terA) | nrPKS | terrein | [ |
2 | ATEG_03432 | nrPKS | 6-acetyl-2,7-dihydroxy-3-methylnaphthalene-1,4-dione | [ |
3 | ATEG_06275 (atX) | hrPKS | terreic acid | [ |
4 | ATEG_08451 (gedC) | nrPKS | geodin | [ |
5 | ATEG_10080 (trt4) | nrPKS | terretonin | [ |
6 | ATEG_09617 (ctvA) | hrPKS | citreoviridin | [ |
7 | ATEG_09961 (lovB) | hrPKS | lovastatin | [ |
ATEG_09968 (lovF) | hrPKS | |||
8 | Atcurs1 | hrPKS | 10,11-dehydrocurvularin | [ |
Atcurs2 | nrPKS | |||
9 | ATEG_03629 | nrPKS | azasperpyranone A | [ |
ATEG_03630 | NRPS-like | |||
ATEG_07659 | hrPKS | |||
ATEG_07661 | nrPKS | |||
10 | ATEG_03470 (ataP) | NRPS | acetylaranotin | [ |
11 | ATEG_10305 (anaPS) | NRPS | asterrelenin | [ |
12 | ATEG_09064 (apmB) | NRPS | asperphenamate | [ |
ATEG_09068 (apmA) | NRPS | |||
13 | ATEG_00700 (atqA) | NRPS-like | asterriquinones CT5 | [ |
14 | ATEG_02004 (apvA) | NRPS-like | aspulvinones B1 | [ |
15 | ATEG_02815 (btyA) | NRPS-like | butyrolactones I | [ |
16 | ATEG_03563 (atmelA) | NRPS-like | aspulvinone E (asp-melanin前体) | [ |
17 | ATEG_08899 (pgnA) | NRPS-like | phenguignardic acid | [ |
18 | ATEG_00325 | PKS-NRPS | isoflavipucine | [ |
19 | ATEG_00913 (pytA) | PKS-NRPS | pyranterreone C | [ |
20 | ATEG_04416 (astA) | TC | aspterric acid | [ |
Tab. 1 Biosynthetic gene clusters and products identified in A. terreus
序号 | 核心基因编号 | 类型 | 代表性产物 | 参考文献 |
---|---|---|---|---|
1 | ATEG_00145 (terA) | nrPKS | terrein | [ |
2 | ATEG_03432 | nrPKS | 6-acetyl-2,7-dihydroxy-3-methylnaphthalene-1,4-dione | [ |
3 | ATEG_06275 (atX) | hrPKS | terreic acid | [ |
4 | ATEG_08451 (gedC) | nrPKS | geodin | [ |
5 | ATEG_10080 (trt4) | nrPKS | terretonin | [ |
6 | ATEG_09617 (ctvA) | hrPKS | citreoviridin | [ |
7 | ATEG_09961 (lovB) | hrPKS | lovastatin | [ |
ATEG_09968 (lovF) | hrPKS | |||
8 | Atcurs1 | hrPKS | 10,11-dehydrocurvularin | [ |
Atcurs2 | nrPKS | |||
9 | ATEG_03629 | nrPKS | azasperpyranone A | [ |
ATEG_03630 | NRPS-like | |||
ATEG_07659 | hrPKS | |||
ATEG_07661 | nrPKS | |||
10 | ATEG_03470 (ataP) | NRPS | acetylaranotin | [ |
11 | ATEG_10305 (anaPS) | NRPS | asterrelenin | [ |
12 | ATEG_09064 (apmB) | NRPS | asperphenamate | [ |
ATEG_09068 (apmA) | NRPS | |||
13 | ATEG_00700 (atqA) | NRPS-like | asterriquinones CT5 | [ |
14 | ATEG_02004 (apvA) | NRPS-like | aspulvinones B1 | [ |
15 | ATEG_02815 (btyA) | NRPS-like | butyrolactones I | [ |
16 | ATEG_03563 (atmelA) | NRPS-like | aspulvinone E (asp-melanin前体) | [ |
17 | ATEG_08899 (pgnA) | NRPS-like | phenguignardic acid | [ |
18 | ATEG_00325 | PKS-NRPS | isoflavipucine | [ |
19 | ATEG_00913 (pytA) | PKS-NRPS | pyranterreone C | [ |
20 | ATEG_04416 (astA) | TC | aspterric acid | [ |
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