Synthetic Biology Journal ›› 2024, Vol. 5 ›› Issue (2): 281-293.DOI: 10.12211/2096-8280.2023-063
• Invited Review • Previous Articles Next Articles
Busen WANG, Jinghan XU, Zhiqiang GAO, Lihua HOU
Received:
2023-08-30
Revised:
2023-12-13
Online:
2024-04-28
Published:
2024-04-30
Contact:
Lihua HOU
王步森, 徐婧含, 高智强, 侯利华
通讯作者:
侯利华
作者简介:
基金资助:
CLC Number:
Busen WANG, Jinghan XU, Zhiqiang GAO, Lihua HOU. Advances in virus-vectored vaccines[J]. Synthetic Biology Journal, 2024, 5(2): 281-293.
王步森, 徐婧含, 高智强, 侯利华. 病毒载体疫苗研究进展[J]. 合成生物学, 2024, 5(2): 281-293.
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URL: https://synbioj.cip.com.cn/EN/10.12211/2096-8280.2023-063
病毒种类 | 基因组 | 主要型别 | ||||
---|---|---|---|---|---|---|
类型 | 长度/kb | 容量/kb | 是否入核 | 是否整合 | ||
腺病毒 | DNA | 36 | 7~8 | 是 | 否 | 5型[ |
痘病毒 | DNA | 170~300 | 25 | 否 | 否 | 痘苗安卡拉株[ |
水疱性口炎病毒 | RNA | 11 | 4.5 | 否 | 否 | 印第安纳株[ |
黄病毒 | RNA | 10 | 2 | 否 | 否 | 黄热病毒[ |
疱疹病毒 | DNA | 140~230 | 30 | 是 | 是 | 水痘-带状疱疹病毒[ |
Table 1 Major viral vectors used in vaccine development
病毒种类 | 基因组 | 主要型别 | ||||
---|---|---|---|---|---|---|
类型 | 长度/kb | 容量/kb | 是否入核 | 是否整合 | ||
腺病毒 | DNA | 36 | 7~8 | 是 | 否 | 5型[ |
痘病毒 | DNA | 170~300 | 25 | 否 | 否 | 痘苗安卡拉株[ |
水疱性口炎病毒 | RNA | 11 | 4.5 | 否 | 否 | 印第安纳株[ |
黄病毒 | RNA | 10 | 2 | 否 | 否 | 黄热病毒[ |
疱疹病毒 | DNA | 140~230 | 30 | 是 | 是 | 水痘-带状疱疹病毒[ |
Fig. 1 Schematic diagrams for the genome structure of virus-vectored vaccines[(a) Genome structure of AdV-vectored vaccines. The E1 and E3 regions in the genome are all deleted, and the expression cassette can be inserted into the E1 deletion site by splicing in vitro. (b) Genome structure of MVA-based vaccines. The thymidine kinase (TK) in the genome is designed as site for gene insertion, and the expression cassette can be inserted by homologous recombination in the sensitive cells. (c) Genome structure of VSV-based vaccines. The glycoprotein of VSV can be replaced by the glycoprotein from other enveloped viruses. (d) Genome structure of YFV-based vaccines. The prM and E proteins in the YFV genome can be replaced by prM and E proteins from other flaviviruses. (e) Genome structure of HSV-based vaccines. The expression cassettes can be inserted into the UL or US regions in the viral genome.]
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