合成生物制造进展

doi:10.12211/2096-8280.2020-052

合成生物学 ›› 2021, Vol. 2 ›› Issue (2): 145-160.DOI: 10.12211/2096-8280.2020-052

合成生物制造进展

张媛媛¹, 曾艳², 王钦宏¹

^1.中国科学院天津工业生物技术研究所，中国科学院系统微生物工程重点实验室，天津 300308
^2.中国科学院科技促进发展局，北京 100864

收稿日期:2020-06-07 修回日期:2021-02-04 出版日期:2021-04-30 发布日期:2021-04-30
通讯作者: 王钦宏
作者简介:张媛媛（1985—），女，硕士，助理研究员。研究方向为进化与代谢工程。E-mail：zhang_yy@tib.cas.cn|王钦宏（1974—），男，博士，研究员。研究方向为化学品代谢途径构建，发展基因组水平编辑和进化策略以及液滴微流控高通量筛选系统，进行生产重要化学品的细胞工厂优化改造，获得实用高性能微生物细胞工厂。E-mail：wang_qh@tib.cas.cn
基金资助:
国家新药创制重大专项(2018ZX09711001-006-003);中国科学院科技服务网络计划（STS计划）(KFJ-STS-ZDTP-065)

Advances in synthetic biomanufacturing

Yuanyuan ZHANG¹, Yan ZENG², Qinhong WANG¹

^1.Tianjin Institute of Industrial Biotechnology，CAS Key Laboratory of Systems Microbial Biotechnology，Chinese Academy of Sciences，Tianjin 300308，China
^2.Bureau of Science and Technology for Development，Chinese Academy of Sciences，Beijing 100864，China

Received:2020-06-07 Revised:2021-02-04 Online:2021-04-30 Published:2021-04-30
Contact: Qinhong WANG

摘要/Abstract

摘要：

合成生物制造是以合成生物为工具进行物质加工与合成的生产方式，有望彻底变革未来医药、化工、食品、能源、材料、农业等传统模式，触发新的产业变革，引领新的产业模式和经济形态，重塑碳基物质文明。合成生物制造具有清洁、高效、可再生等特点，能够减少工业经济对生态环境的影响。本文综述了近年来合成生物制造在大宗发酵产品、精细与医药化学品、可再生化学品与聚合材料、天然产物、未来农产品以及一碳原料利用方面的重要进展，对各领域代表性重大产品的技术进展及产业应用状况与潜力进行了探讨。未来，随着合成生物学发展，以及与人工智能、大数据等新技术的融合，通过合成生物制造可以获得更多的生物基产品，促进生物经济形成，更好地服务于人类社会的可持续发展。

关键词: 合成生物学, 生物制造, 可再生原料, 生物基产品, 生物经济

Abstract:

Synthetic biomanufacturing is a paradigm for material processing and synthesis via synthetic biology. It is expected to completely transform the traditional production mode for medicines, chemicals, food, energy, materials and agriculture in the future, trigger new industrial revolution, lead to new economic growth and reshape carbon-based civilization. In particular, the COVID-19 global spread that has accelerated the reshaping process of the world's economic and social development. In the foreseeable future, human life and production patterns will undergo profound changes in medicines and healthcare, food and agriculture, energy and materials, etc., during which demands for new technologies will promote evolution in the field of biotechnology, and the biomanufacturing industry in the post COVID-19 era is facing unprecedented opportunities for revitalization and new challenges. According to the analysis of the research report from the Ministry of Economy, Trade and Industry of Japan, engineered biological cells and their combination with information & artificial intelligence technologies will become the main driving force for the "post-fourth industrial revolution".Synthetic biomanufacturing has the characteristics of cleanliness, efficiency and renewableness that can reduce the impact of industrial economy on the ecological environment. Here, in this review, we summarize the progress of synthetic biomanufacturing with respect to bulk fermentation products, fine and pharmaceutical chemicals, renewable chemicals and bio-based polymeric materials, natural products, foods and the utilization of C₁ raw materials. The technological progress, status and potential of industrial applications of many important bio-based products via synthetic biomanufacturing are analyzed and discussed. The development of synthetic biomanufacturing shows great potentials for building up the ecological route of industrial economy and addressing current issues of economic sustainability in terms of limited substrate, high cost, and poor viability, and to form whole new industry chain with sustainable growth. In the future, with the development of synthetic biology, and the integration of new technologies such as artificial intelligence and big data, more and more bio-based products can be produced via synthetic biomanufacturing. The formation of bioeconomy can be promoted, and the sustainable development of human society will be better served.

Key words: synthetic biology, biomanufacturing, renewable feedstock, bio-based product, bioeconomy

中图分类号:

张媛媛, 曾艳, 王钦宏. 合成生物制造进展[J]. 合成生物学, 2021, 2(2): 145-160.

Yuanyuan ZHANG, Yan ZENG, Qinhong WANG. Advances in synthetic biomanufacturing[J]. Synthetic Biology Journal, 2021, 2(2): 145-160.

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合成生物制造进展

Advances in synthetic biomanufacturing

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