Yining LIU1,2, Wei PU3,4, Jinxing YANG5, Yu WANG1,2
Received:
2024-02-04
Revised:
2024-04-25
Published:
2024-06-24
Contact:
Yu WANG
刘益宁1,2, 蒲伟3,4, 杨金星5, 王钰1,2
通讯作者:
王钰
作者简介:
基金资助:
CLC Number:
Yining LIU, Wei PU, Jinxing YANG, Yu WANG. Recent advances in the biosynthesis of ω-amino acids and lactams[J]. Synthetic Biology Journal, DOI: 10.12211/2096-8280.2024-019.
刘益宁, 蒲伟, 杨金星, 王钰. ω-氨基酸与内酰胺的生物合成研究进展[J]. 合成生物学, DOI: 10.12211/2096-8280.2024-019.
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URL: https://synbioj.cip.com.cn/EN/10.12211/2096-8280.2024-019
Fig. 2 Biosynthetic pathways for ω-amino acids(aspC: Encodes aspartate transaminase; lysC: Encodes aspartate kinase; dapA: Encodes dihydrodipicolinate synthase; dapB: Encodes 4-hydroxy-tetrahydrodipicolinate reductase; ddh: Encodes meso-diaminopimelate dehydrogenase; lysA: Encodes diaminopimelate decarboxylase; davA: Encodes 5-aminopentanamide hydrolase; davB: Encodes lysine monooxygenase; patD: Encodes γ-aminobutyraldehyde dehydrogenase; ldcC: Encodes lysine decarboxylase; cadA: Encodes lysine decarboxylase; patA: Encodes putrescine aminotransferase; puuA/ygjG: Encodes putrescine transaminase; lysOx/raiP: Encodes lysine α-oxidase; kivD: Encodes 2-ketoisovalerate decarboxylase; padA: Encodes phenylacetaldehyde dehydrogenase; nifV: Encodes homocitrate synthase; kdcA: Encodes ketoacid decarboxylase; vfl: Encodes aminotransferase; argA: Encodes amino acid acetyltransferase; argB: Encodes N-acetylglutamate kinase; argC: Encodes N-acetylglutamate-phosphate reductase; argD: Encodes ornithine transcarbamoylase; argE: Encodes ornithine carbamoyltransferase; argJ: Encodes ornithine acetyltransferase; speC/speF: Encodes ornithine decarboxylase; gadB: Encodes glutamate decarboxylase β subunit; gadA: Encodes glutamate decarboxylase α subunit; gadC: Encodes glutamate/GABA antiporter; leuA: Encodes α-isopropylmalate synthase; leuB: Encodes 3-isopropylmalate dehydrogenase; leuCD: Encodes 3-isopropylmalate dehydratase; aksD: Encodes isopropylmalate dehydratase large subunit; aksE: Encodes isopropylmalate dehydratase small subunit; aksF: Encodes isopropylmalate/homoisocitrate dehydrogenase.)
微生物底盘 | 基因型 | 培养模式 | 碳源 | 生产水平(产量g/L、生产强度g/L·h和转化率g/g) | 参考文献 |
---|---|---|---|---|---|
E. coli BW25113 | ΔgadAB, P araBAD : gadBopt from L. lactis | 反应器补料分批发酵 | 谷氨酸钠 | 614.15 /40.94 /0.99 | [ |
L. paracasei NFRI 7415 | 野生型 | 反应器补料分批发酵 | 谷氨酸钠 | 31.1 /0.185 /0.37 | [ |
S. salivarius subsp.thermophilus Y2 | 野生型 | 反应器补料分批发酵 | 谷氨酸钠 | 7.98 /0.095 /0.53 | [ |
L. brevis NCL912 | 野生型 | 反应器补料分批发酵 | 葡萄糖 | 205.8 /4.29 /1.43 | [ |
E. coli BL21(DE3) | P ADH1 : gadA | 反应器补料分批发酵 | 葡萄糖,谷氨酸钠 | 300 /8.57 /0.69 | [ |
E. coli XL1-Blue | P gntT104 : gadB from L. brevis subsp. Lactis IL1403 | 反应器补料分批发酵 | 葡萄糖,谷氨酸钠 | 94.8 /1.98 /0.777 | [ |
E. coli XL1-Blue | P tac : gadB from N. crassa | 摇瓶发酵 | 谷氨酸钠 | 5.35 /0.11 /0.878 | [ |
E. coli XL1-Blue | P tac : gadB from P. horikoshii | 摇瓶发酵 | 谷氨酸钠 | 5.07 /0.11 /0.83 | [ |
E. coli BL21(DE3) | P T7 : GAD from S. cerevisiae | 反应器补料分批发酵 | 乳糖,甘油 | 252 /- /0.99 | [ |
E. coli BL21(DE3) | P T7 : GAD from L. lactis FJNUGA01 | 反应器补料分批发酵 | 谷氨酸钠 | 204.1 /34 /0.99 | [ |
E. coli BL21(DE3) | P T7 : gadA, gadB, gadC from E. coli | 反应器补料分批发酵 | 谷氨酸钠 | 31.3 /0.55 /- | [ |
E. coli XBT | ΔgabT, P T7 : gadBC from E. coli | 摇瓶发酵 | 谷氨酸钠 | 5.46 /0.114 /0.895 | [ |
E. coli BW25113 | ΔgadC, ΔgadAB, P araBAD : gadB (M4)-groES-groEL, gadB mutant from L. lactis IL1403 | 反应器补料分批发酵 | 谷氨酸钠 | 308.26 /44.04 /0.996 | [ |
E. coli XBM3 | ΔackA, gabT, P arcC : icd-GBD, gltB-SH3, gadA-PDZ from E. coli | 摇瓶发酵 | 葡萄糖 | 1.3 /0.027 /0.13 | [ |
E. coli (XL1-Blue) XBM4 | ΔfrdB, gabT, P araBAD : gadC-GBD, gltB-SH3, gadB-PDZ from E. coli | 摇瓶发酵 | 葡萄糖 | 1.23 /0.026 /0.123 | [ |
E. coli (XL1-Blue) XBM6 | ΔpflB, poxB, ldhA, P arcC: gadC-GDB, gabD-SH3, gabT-PDZ from E. coli | 摇瓶发酵 | 葡萄糖 | 0.79 /0.016 /0.079 | [ |
E. coli XBM7 | ΔackA, ldhA, P araC : sdhA-GBD, gabD-SH3, gabT-PDZ from E. coli | 摇瓶发酵 | 葡萄糖 | 0.75 /0.016 /0.075 | [ |
E. coli XBM6 | ΔpflB, ΔpoxB, ΔldhA, P arcC : gadD-GDB, gabD-SH3, puuE-PDZ from E. coli | 摇瓶发酵 | 葡萄糖 | 0.87 /- /- | [ |
E. coli JWZ08 | ΔwaaF, ΔwaaC, ΔsucA, ΔpuuE, ΔgabT, ΔgabP, ΔxylA, ΔxylB, P T7 : xylB, xylX, xylD, xylC, xylA from C. crescentus NA1000, P T7: gdhA and torA-gadB from E. coli | 摇瓶发酵 | 木糖 | 3.95 /0.065 /0.20 | [ |
E. coli BW25113 | ΔlacI, ΔgabT, ΔsucA, ΔaceA, P LlacO1 ::gltB, gadB(E89Q,Δ452–466), gadC (1–470), glnA from E. coli | 摇瓶发酵 | 葡萄糖 | 4.8 /0.15 /0.29 | [ |
E. coli EDK11 | gadB, gadC, gabT, gltA from E. coli | 摇瓶发酵 | 葡萄糖 | 1.2 /0.05 /- | [ |
E. coli Nissle 1917pMT1-G/pMT2-R/EcNP | P trc : gadB from E. coli | 全细胞催化 | 谷氨酸钠 | 17.9 /- /- | [ |
C. glutamicum GAD | P HCE : gadB from E. coli | 摇瓶发酵 | 葡萄糖 | 12.37 /0.172 /0.247 | [ |
C. glutamicum ATCC 13032 | P tacM : gadB1, gadB2 from L. brevis Lb85 | 摇瓶发酵 | 葡萄糖 | 27.13 /0.226 /0.52 | [ |
C. glutamicum ATCC 13032 | P H36 : gadB(E89Q, Δ452–466) from E. coli | 反应器补料分批发酵 | 葡萄糖 | 38.6 /0.536 /0.32 | [ |
C. glutamicum H36GD1852 | P H36 : gadBmut, xylAB from E. coli | 反应器补料分批发酵 | EFB | 35.47 /0.68 /- | [ |
C. glutamicum SH | P tacM : R4a-gabB2B1mut from L. brevis | 摇瓶发酵 | 葡萄糖 | 26.5 /0.442 /0.269 | [ |
C. glutamicum ATCC 13032 | ΔcglIM, ΔcglIR, ΔcglIIR, Δncgl0464 LVIS1847 from L. brevis ATCC367 | 摇瓶发酵 | 葡萄糖 | 25.6 /2.4 /0.729 | [ |
C. glutamicum ATCC 13032 | ΔpknG, P HCE : gadB from E. coli | 摇瓶发酵 | 葡萄糖 | 31.1 /0.26 /0.311 | [ |
C. glutamicum ATCC 13032 | ΔodhA, P tac : gadB1, gadB2 from E. coli | 反应器补料分批发酵 | 葡萄糖 | 29.5 /0.41 /- | [ |
C. glutamicum SH | Δmdh, P tac : gadB1, gadB2, ppc from E. coli | 反应器补料分批发酵 | 葡萄糖 | 26.3 /0.365 /- | [ |
C. glutamicum PUT21 | ΔargF, ΔargR, ΔsnaA, ΔgabTDP, P tac : patD, patA from E. coli, P tac : speC-5′21-argF | 摇瓶发酵 | 葡萄糖 | 8.0 /0.31 /- | [ |
C. glutamicum APLGGP | ΔargB, ΔproB, ΔdapA, P tac: plk from L. plantarum GB 01–21, gad from L. plantarum GB 01–21 | 反应器补料分批发酵 | 葡萄糖 | 70.6 /1.001 /- | [ |
C. glutamicum ORN1 | ΔargF, ΔargR, ΔsnaA, ΔgabTDP, ΔyggB, ΔcgmA, odhATTG, odhIT15A, P tac : patDA from E. coli, Ptac: gapA, pyc and argBA49V/M54V from C. glutamicum, speC from E. coli and leaky expression of argF | 反应器补料分批发酵 | 葡萄糖 | 63.2 /1.34 /0.24 | [ |
C. glutamicum ATCC 13032 | ΔargR, ΔgabT, ΔgabP, P tac : gadB2 from L. brevis ATCC 367 | 摇瓶发酵 | 葡萄糖 | 28.7 /0.3 /- | [ |
C. glutamicum ATCC 13032 | P tuf :can, P tuf :icd, ΔsucCD, ΔgabD, ΔgabP::potE harboring pXMJ19-P tuf : guaB-gadM | 反应器补料分批发酵 | 葡萄糖 | 23.07 /0.38 /0.52 | [ |
C. glutamicum KCTC 1852 H36LlGAD | P H36 : gadB from L. lactis CICC20209 | 反应器补料分批发酵 | 葡萄糖 | 42.5 /1.18 /0.425 | [ |
L.brevisNCL912 | 野生型 | 反应器补料分批发酵 | 谷氨酸钠 | 103.7 /- /- | [ |
C. glutamicum ATCC 13032 | CgGly 2, ∆gabTDP, P GPP1-odhA-DAS+8, P GPP1-argJ-DAS+8; pGN-GGPCe | 反应器补料分批发酵 | 甘油 | 45.6 /- /0.4 | [ |
Table 1 Biosynthesis of γ-aminobutyric acid
微生物底盘 | 基因型 | 培养模式 | 碳源 | 生产水平(产量g/L、生产强度g/L·h和转化率g/g) | 参考文献 |
---|---|---|---|---|---|
E. coli BW25113 | ΔgadAB, P araBAD : gadBopt from L. lactis | 反应器补料分批发酵 | 谷氨酸钠 | 614.15 /40.94 /0.99 | [ |
L. paracasei NFRI 7415 | 野生型 | 反应器补料分批发酵 | 谷氨酸钠 | 31.1 /0.185 /0.37 | [ |
S. salivarius subsp.thermophilus Y2 | 野生型 | 反应器补料分批发酵 | 谷氨酸钠 | 7.98 /0.095 /0.53 | [ |
L. brevis NCL912 | 野生型 | 反应器补料分批发酵 | 葡萄糖 | 205.8 /4.29 /1.43 | [ |
E. coli BL21(DE3) | P ADH1 : gadA | 反应器补料分批发酵 | 葡萄糖,谷氨酸钠 | 300 /8.57 /0.69 | [ |
E. coli XL1-Blue | P gntT104 : gadB from L. brevis subsp. Lactis IL1403 | 反应器补料分批发酵 | 葡萄糖,谷氨酸钠 | 94.8 /1.98 /0.777 | [ |
E. coli XL1-Blue | P tac : gadB from N. crassa | 摇瓶发酵 | 谷氨酸钠 | 5.35 /0.11 /0.878 | [ |
E. coli XL1-Blue | P tac : gadB from P. horikoshii | 摇瓶发酵 | 谷氨酸钠 | 5.07 /0.11 /0.83 | [ |
E. coli BL21(DE3) | P T7 : GAD from S. cerevisiae | 反应器补料分批发酵 | 乳糖,甘油 | 252 /- /0.99 | [ |
E. coli BL21(DE3) | P T7 : GAD from L. lactis FJNUGA01 | 反应器补料分批发酵 | 谷氨酸钠 | 204.1 /34 /0.99 | [ |
E. coli BL21(DE3) | P T7 : gadA, gadB, gadC from E. coli | 反应器补料分批发酵 | 谷氨酸钠 | 31.3 /0.55 /- | [ |
E. coli XBT | ΔgabT, P T7 : gadBC from E. coli | 摇瓶发酵 | 谷氨酸钠 | 5.46 /0.114 /0.895 | [ |
E. coli BW25113 | ΔgadC, ΔgadAB, P araBAD : gadB (M4)-groES-groEL, gadB mutant from L. lactis IL1403 | 反应器补料分批发酵 | 谷氨酸钠 | 308.26 /44.04 /0.996 | [ |
E. coli XBM3 | ΔackA, gabT, P arcC : icd-GBD, gltB-SH3, gadA-PDZ from E. coli | 摇瓶发酵 | 葡萄糖 | 1.3 /0.027 /0.13 | [ |
E. coli (XL1-Blue) XBM4 | ΔfrdB, gabT, P araBAD : gadC-GBD, gltB-SH3, gadB-PDZ from E. coli | 摇瓶发酵 | 葡萄糖 | 1.23 /0.026 /0.123 | [ |
E. coli (XL1-Blue) XBM6 | ΔpflB, poxB, ldhA, P arcC: gadC-GDB, gabD-SH3, gabT-PDZ from E. coli | 摇瓶发酵 | 葡萄糖 | 0.79 /0.016 /0.079 | [ |
E. coli XBM7 | ΔackA, ldhA, P araC : sdhA-GBD, gabD-SH3, gabT-PDZ from E. coli | 摇瓶发酵 | 葡萄糖 | 0.75 /0.016 /0.075 | [ |
E. coli XBM6 | ΔpflB, ΔpoxB, ΔldhA, P arcC : gadD-GDB, gabD-SH3, puuE-PDZ from E. coli | 摇瓶发酵 | 葡萄糖 | 0.87 /- /- | [ |
E. coli JWZ08 | ΔwaaF, ΔwaaC, ΔsucA, ΔpuuE, ΔgabT, ΔgabP, ΔxylA, ΔxylB, P T7 : xylB, xylX, xylD, xylC, xylA from C. crescentus NA1000, P T7: gdhA and torA-gadB from E. coli | 摇瓶发酵 | 木糖 | 3.95 /0.065 /0.20 | [ |
E. coli BW25113 | ΔlacI, ΔgabT, ΔsucA, ΔaceA, P LlacO1 ::gltB, gadB(E89Q,Δ452–466), gadC (1–470), glnA from E. coli | 摇瓶发酵 | 葡萄糖 | 4.8 /0.15 /0.29 | [ |
E. coli EDK11 | gadB, gadC, gabT, gltA from E. coli | 摇瓶发酵 | 葡萄糖 | 1.2 /0.05 /- | [ |
E. coli Nissle 1917pMT1-G/pMT2-R/EcNP | P trc : gadB from E. coli | 全细胞催化 | 谷氨酸钠 | 17.9 /- /- | [ |
C. glutamicum GAD | P HCE : gadB from E. coli | 摇瓶发酵 | 葡萄糖 | 12.37 /0.172 /0.247 | [ |
C. glutamicum ATCC 13032 | P tacM : gadB1, gadB2 from L. brevis Lb85 | 摇瓶发酵 | 葡萄糖 | 27.13 /0.226 /0.52 | [ |
C. glutamicum ATCC 13032 | P H36 : gadB(E89Q, Δ452–466) from E. coli | 反应器补料分批发酵 | 葡萄糖 | 38.6 /0.536 /0.32 | [ |
C. glutamicum H36GD1852 | P H36 : gadBmut, xylAB from E. coli | 反应器补料分批发酵 | EFB | 35.47 /0.68 /- | [ |
C. glutamicum SH | P tacM : R4a-gabB2B1mut from L. brevis | 摇瓶发酵 | 葡萄糖 | 26.5 /0.442 /0.269 | [ |
C. glutamicum ATCC 13032 | ΔcglIM, ΔcglIR, ΔcglIIR, Δncgl0464 LVIS1847 from L. brevis ATCC367 | 摇瓶发酵 | 葡萄糖 | 25.6 /2.4 /0.729 | [ |
C. glutamicum ATCC 13032 | ΔpknG, P HCE : gadB from E. coli | 摇瓶发酵 | 葡萄糖 | 31.1 /0.26 /0.311 | [ |
C. glutamicum ATCC 13032 | ΔodhA, P tac : gadB1, gadB2 from E. coli | 反应器补料分批发酵 | 葡萄糖 | 29.5 /0.41 /- | [ |
C. glutamicum SH | Δmdh, P tac : gadB1, gadB2, ppc from E. coli | 反应器补料分批发酵 | 葡萄糖 | 26.3 /0.365 /- | [ |
C. glutamicum PUT21 | ΔargF, ΔargR, ΔsnaA, ΔgabTDP, P tac : patD, patA from E. coli, P tac : speC-5′21-argF | 摇瓶发酵 | 葡萄糖 | 8.0 /0.31 /- | [ |
C. glutamicum APLGGP | ΔargB, ΔproB, ΔdapA, P tac: plk from L. plantarum GB 01–21, gad from L. plantarum GB 01–21 | 反应器补料分批发酵 | 葡萄糖 | 70.6 /1.001 /- | [ |
C. glutamicum ORN1 | ΔargF, ΔargR, ΔsnaA, ΔgabTDP, ΔyggB, ΔcgmA, odhATTG, odhIT15A, P tac : patDA from E. coli, Ptac: gapA, pyc and argBA49V/M54V from C. glutamicum, speC from E. coli and leaky expression of argF | 反应器补料分批发酵 | 葡萄糖 | 63.2 /1.34 /0.24 | [ |
C. glutamicum ATCC 13032 | ΔargR, ΔgabT, ΔgabP, P tac : gadB2 from L. brevis ATCC 367 | 摇瓶发酵 | 葡萄糖 | 28.7 /0.3 /- | [ |
C. glutamicum ATCC 13032 | P tuf :can, P tuf :icd, ΔsucCD, ΔgabD, ΔgabP::potE harboring pXMJ19-P tuf : guaB-gadM | 反应器补料分批发酵 | 葡萄糖 | 23.07 /0.38 /0.52 | [ |
C. glutamicum KCTC 1852 H36LlGAD | P H36 : gadB from L. lactis CICC20209 | 反应器补料分批发酵 | 葡萄糖 | 42.5 /1.18 /0.425 | [ |
L.brevisNCL912 | 野生型 | 反应器补料分批发酵 | 谷氨酸钠 | 103.7 /- /- | [ |
C. glutamicum ATCC 13032 | CgGly 2, ∆gabTDP, P GPP1-odhA-DAS+8, P GPP1-argJ-DAS+8; pGN-GGPCe | 反应器补料分批发酵 | 甘油 | 45.6 /- /0.4 | [ |
微生物底盘 | 基因型 | 培养模式 | 碳源 | 生产水平(产量g/L、生产强度g/L·h和转化率g/g) | 参考文献 |
---|---|---|---|---|---|
E. coli WL3110 | P LlacO-1 : davAB from P. putida | 摇瓶发酵 | 葡萄糖,L-赖氨酸 | 3.6 /0.075 /– | [ |
E. coli WL3110 | pKE112-davAB from P. putida | 反应器补料分批发酵 | 葡萄糖,L-赖氨酸 | 90.59 /- /0.942 | [ |
E. coli CJ02RaiP | ΔcadA, raiP from E. coli | 全细胞催化 | L-赖氨酸 | 50.62 /1.05 /0.506 | [ |
C. glutamicum KCTC 12390BP | ΔgabT, P H36 : davAHis6davB from E. coli | 反应器补料分批发酵 | 葡萄糖 | 33.1 /0.22 /0.1 | [ |
C. glutamicum LYS-12 | bioD::davBA from P. putida, ΔlysE, ΔgabT | 反应器补料分批发酵 | 葡萄糖 | 28 /0.9 /0.11 | [ |
C. glutamicum KCTC 1857 | P H30 : davBA from P. putida | 反应器补料分批发酵 | 葡萄糖 | 39.9 /0.54 /0.11 | [ |
C. glutamicum AVA-7 | ΔargD, ΔgabTDP, ΔlysE, P tuf: davBA from P. putida KT2440 and PP2911 from P. putida KT2440 | 反应器补料分批发酵 | 葡萄糖 | 46.5 /1.52 /0.34 | [ |
E. coli WL3110 | P LlacO-1: davAB from P. putida | 反应器补料分批发酵 | 葡萄糖 | 90.59 /0.94 /0.75 | [ |
E. coli BW25113 (DE3) | ΔcadA, ΔldcC, P lac: davBA from P. putida KT2440, P T7 : lysCT352I, dapA from C. glutamicum | 摇瓶发酵 | 葡萄糖 | 0.86 /0.018 /0.046 | [ |
E. coli BL21(DE3) | P T7 : davA from P. putida KT2440, P T7 : davB from P. putida KT244 | 反应器补料分批发酵 | L-赖氨酸 | 240.7 /8.6 /0.868 | [ |
E. coli pDABLP | P T7 : davAB from P. putida KT2440, P T7 : lysP, P T7 : PP2911 from P. putida | 反应器补料分批发酵 | 葡萄糖 | 63.2 /0.405 /0.62 | [ |
E. coli BL21(DE3) | ΔcadA, P T7 : raiP from S. japonicus | 全细胞催化 | L-赖氨酸 | 29.12 /0.40 /0.44 | [ |
E. coli CJ09 | ΔcadA, raiP from S. japonicus, kivg(F381A/V461A) from L. lactis, pad, katE, lysP from E. coli | 反应器补料分批发酵 | 葡萄糖,L-赖氨酸 | 52.24 /1.19 /0.38 | [ |
C. glutamicum 5AVA3 | ΔsugR, ΔldhA, ΔsnaA, ΔcgmA, ΔgabTDP, P tac : ldcC, P tac : patAD from E. coli | 摇瓶发酵 | 葡萄糖和其他碳源 | 5.1 /0.12 /0.13 | [ |
C. glutamicum AVA2_puoRq | ΔsugR, ΔldhA, ΔsnaA, ΔcgmA, ΔgabTDP, pVWEx1-ldcC, pEC-XT99A-puoRq-patD | 微型生物发酵系统 | 葡萄糖 | 3.7 /- /0.09 | [ |
Table 2 Biosynthesis of 5-aminovaleric acid
微生物底盘 | 基因型 | 培养模式 | 碳源 | 生产水平(产量g/L、生产强度g/L·h和转化率g/g) | 参考文献 |
---|---|---|---|---|---|
E. coli WL3110 | P LlacO-1 : davAB from P. putida | 摇瓶发酵 | 葡萄糖,L-赖氨酸 | 3.6 /0.075 /– | [ |
E. coli WL3110 | pKE112-davAB from P. putida | 反应器补料分批发酵 | 葡萄糖,L-赖氨酸 | 90.59 /- /0.942 | [ |
E. coli CJ02RaiP | ΔcadA, raiP from E. coli | 全细胞催化 | L-赖氨酸 | 50.62 /1.05 /0.506 | [ |
C. glutamicum KCTC 12390BP | ΔgabT, P H36 : davAHis6davB from E. coli | 反应器补料分批发酵 | 葡萄糖 | 33.1 /0.22 /0.1 | [ |
C. glutamicum LYS-12 | bioD::davBA from P. putida, ΔlysE, ΔgabT | 反应器补料分批发酵 | 葡萄糖 | 28 /0.9 /0.11 | [ |
C. glutamicum KCTC 1857 | P H30 : davBA from P. putida | 反应器补料分批发酵 | 葡萄糖 | 39.9 /0.54 /0.11 | [ |
C. glutamicum AVA-7 | ΔargD, ΔgabTDP, ΔlysE, P tuf: davBA from P. putida KT2440 and PP2911 from P. putida KT2440 | 反应器补料分批发酵 | 葡萄糖 | 46.5 /1.52 /0.34 | [ |
E. coli WL3110 | P LlacO-1: davAB from P. putida | 反应器补料分批发酵 | 葡萄糖 | 90.59 /0.94 /0.75 | [ |
E. coli BW25113 (DE3) | ΔcadA, ΔldcC, P lac: davBA from P. putida KT2440, P T7 : lysCT352I, dapA from C. glutamicum | 摇瓶发酵 | 葡萄糖 | 0.86 /0.018 /0.046 | [ |
E. coli BL21(DE3) | P T7 : davA from P. putida KT2440, P T7 : davB from P. putida KT244 | 反应器补料分批发酵 | L-赖氨酸 | 240.7 /8.6 /0.868 | [ |
E. coli pDABLP | P T7 : davAB from P. putida KT2440, P T7 : lysP, P T7 : PP2911 from P. putida | 反应器补料分批发酵 | 葡萄糖 | 63.2 /0.405 /0.62 | [ |
E. coli BL21(DE3) | ΔcadA, P T7 : raiP from S. japonicus | 全细胞催化 | L-赖氨酸 | 29.12 /0.40 /0.44 | [ |
E. coli CJ09 | ΔcadA, raiP from S. japonicus, kivg(F381A/V461A) from L. lactis, pad, katE, lysP from E. coli | 反应器补料分批发酵 | 葡萄糖,L-赖氨酸 | 52.24 /1.19 /0.38 | [ |
C. glutamicum 5AVA3 | ΔsugR, ΔldhA, ΔsnaA, ΔcgmA, ΔgabTDP, P tac : ldcC, P tac : patAD from E. coli | 摇瓶发酵 | 葡萄糖和其他碳源 | 5.1 /0.12 /0.13 | [ |
C. glutamicum AVA2_puoRq | ΔsugR, ΔldhA, ΔsnaA, ΔcgmA, ΔgabTDP, pVWEx1-ldcC, pEC-XT99A-puoRq-patD | 微型生物发酵系统 | 葡萄糖 | 3.7 /- /0.09 | [ |
微生物底盘 | 基因型 | 培养模式 | 碳源 | 生产水平(产量g/L、生产强度g/L·h和转化率g/g) | 参考文献 |
---|---|---|---|---|---|
E. coli BL21(DE3) | pZA22-leuA*-leuB-leuC-leuD, pET21a-raiP-kivD-padA | 摇瓶发酵 | L-赖氨酸 | 0.024 /- /- | [ |
E. coli BL21 | Ptac : nifV from A. vineland, aksFopt from M. aeolicus Nankai-3, P tac : aksDopt from M. aeolicus Nankai-3, aksEopt from M. aeolicus Nankai-3, P tac : vflopt from V. fluvialis, kdcAopt from L. lactis | 反应器补料分批发酵 | 葡萄糖 | 2.0 /0.038 /- | [ |
E. coli BL21 | P T7 : nifVopt from A. vinelandi aksFopt from M. aeolicus Nankai-3, P T7 : aksDopt from M. aeolicus Nankai-3, aksEopt from M. aeolicus Nankai-3, P T7 : vflopt from V. fluvialis, kdcAopt from L. lactisa | 摇瓶发酵 | 葡萄糖 | 0.048 /- /- | [ |
Table 3 Biosynthesis of 6-aminocaproic acid
微生物底盘 | 基因型 | 培养模式 | 碳源 | 生产水平(产量g/L、生产强度g/L·h和转化率g/g) | 参考文献 |
---|---|---|---|---|---|
E. coli BL21(DE3) | pZA22-leuA*-leuB-leuC-leuD, pET21a-raiP-kivD-padA | 摇瓶发酵 | L-赖氨酸 | 0.024 /- /- | [ |
E. coli BL21 | Ptac : nifV from A. vineland, aksFopt from M. aeolicus Nankai-3, P tac : aksDopt from M. aeolicus Nankai-3, aksEopt from M. aeolicus Nankai-3, P tac : vflopt from V. fluvialis, kdcAopt from L. lactis | 反应器补料分批发酵 | 葡萄糖 | 2.0 /0.038 /- | [ |
E. coli BL21 | P T7 : nifVopt from A. vinelandi aksFopt from M. aeolicus Nankai-3, P T7 : aksDopt from M. aeolicus Nankai-3, aksEopt from M. aeolicus Nankai-3, P T7 : vflopt from V. fluvialis, kdcAopt from L. lactisa | 摇瓶发酵 | 葡萄糖 | 0.048 /- /- | [ |
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