Wei YU1,2, Jiaoqi GAO1,2, Yongjin ZHOU1,2
Received:
2024-03-19
Revised:
2024-06-04
Published:
2024-06-19
Contact:
Yongjin ZHOU
禹伟1,2, 高教琪1,2, 周雍进1,2
通讯作者:
周雍进
作者简介:
基金资助:
CLC Number:
Wei YU, Jiaoqi GAO, Yongjin ZHOU. Bioconversion of one carbon feedstocks for producing organic acids[J]. Synthetic Biology Journal, DOI: 10.12211/2096-8280.2024-023.
禹伟, 高教琪, 周雍进. 一碳生物转化合成有机酸的研究进展[J]. 合成生物学, DOI: 10.12211/2096-8280.2024-023.
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URL: https://synbioj.cip.com.cn/EN/10.12211/2096-8280.2024-023
Fig. 1 The utilization pathways of C1 sources(a.CO2 utilizing pathway: CBB cycle; b. CO2 utilizing pathway: reductive TCA (rTCA) cycle; c. CO2 utilizing pathway: reductive Glycine (rGly) pathway; d. CO2, CO and formic acid utilizing pathway: WL pathway in acetogen; e. CO2, CO and formic acid utilizing pathway: WL pathway in methanogen; f. CO2 utilizing pathway: DC/HB cycle; g. CO2 utilizing pathway: HP/HB cycle; h. CO2 utilizing pathway: 3-HP cycle; i. methanol utilizing pathway: XuMP cycle; j. methanol utilizing pathway: RuMP cycle; k. methanol and formic acid utilizing pathway: serine cycle; l. methane utilizing pathway: RuMP cycle, CBB cycle and serine cycle.)
产物 | 宿主 | 底物 | 培养条件 | 产量(g/L) | 得率(%) | 生产强度(g/L/d) | 参考文献 |
---|---|---|---|---|---|---|---|
3-HP | 蓝细菌 | CO2 | MM,摇瓶, 50 mL发酵体积 | 0.67 | 2.6 | 0.07 | [ |
蓝细菌 | CO2 | MM,摇瓶, 20 mL发酵体积 | 0.84 | 8.0 | 0.14 | [ | |
甲基弯菌 | 甲烷 | MM,发酵罐, 50 mL发酵体积 | 0.06 | 2.4 | 0.03 | [ | |
扭脱甲基杆菌 | 甲醇 | MM,摇瓶, 50 mL发酵体积 | 0.07 | 2.0 | 0.04 | [ | |
扭脱甲基杆菌 | 甲醇 | MM,发酵罐, 1.8 L发酵体积 | 0.86 | 3.1 | 0.21 | [ | |
多形汉逊酵母 | 甲醇 | MM,摇瓶, 50 mL发酵体积 | 7.10 | 14.2 | 1.20 | [ | |
巴斯德毕赤酵母 | 甲醇 | MM,发酵罐, 300 mL发酵体积 | 48.2 | 23.0 | 3.7 | [ | |
L-乳酸 | 蓝细菌 | CO2 | MM,摇瓶, 80 mL发酵体积 | 1.0 | N.D. | 0.03 | [ |
甲烷氧化菌 | 甲烷 | MM,摇瓶, 2 mL发酵体积 | 0.6 | N.D. | 0.15 | [ | |
多形汉逊酵母 | 甲醇 | MM,摇瓶, 50 mL发酵体积 | 3.8 | 8.0 | 0.69 | [ | |
D-乳酸 | 蓝细菌 | CO2 | MM,发酵罐, 100 mL发酵体积 | 1.3 | N.D. | 0.13 | [ |
甲基单胞菌 | 甲烷 | MM,摇瓶, 12.5 mL发酵体积 | 1.2 | 24.5 | 0.20 | [ | |
巴斯德毕赤酵母 | 甲醇 | CM,摇瓶, 5 mL发酵体积 | 3.5 | 22.0 | 0.87 | [ | |
琥珀酸 | 蓝细菌 | CO2 | MM,发酵罐, 发酵体积未知 | 0.93 | N.D. | 0.19 | [ |
蓝细菌 | CO2 | MM,摇瓶, 40 mL发酵体积 | 0.63 | N.D. | 0.32 | [ | |
蓝细菌 | CO2 | MM,摇瓶, 发酵体积未知 | 1.8 | N.D. | 0.60 | [ | |
蓝细菌 | CO2 | MM,发酵罐, 1 L发酵体积 | 2.5 | N.D. | 0.23 | [ | |
甲基单胞菌 | 甲烷 | MM,发酵罐, 3.2 L发酵体积 | 0.20 | 7.9 | 0.04 | [ |
Table 1 Bio-production of organic acids from C1 feedstocks
产物 | 宿主 | 底物 | 培养条件 | 产量(g/L) | 得率(%) | 生产强度(g/L/d) | 参考文献 |
---|---|---|---|---|---|---|---|
3-HP | 蓝细菌 | CO2 | MM,摇瓶, 50 mL发酵体积 | 0.67 | 2.6 | 0.07 | [ |
蓝细菌 | CO2 | MM,摇瓶, 20 mL发酵体积 | 0.84 | 8.0 | 0.14 | [ | |
甲基弯菌 | 甲烷 | MM,发酵罐, 50 mL发酵体积 | 0.06 | 2.4 | 0.03 | [ | |
扭脱甲基杆菌 | 甲醇 | MM,摇瓶, 50 mL发酵体积 | 0.07 | 2.0 | 0.04 | [ | |
扭脱甲基杆菌 | 甲醇 | MM,发酵罐, 1.8 L发酵体积 | 0.86 | 3.1 | 0.21 | [ | |
多形汉逊酵母 | 甲醇 | MM,摇瓶, 50 mL发酵体积 | 7.10 | 14.2 | 1.20 | [ | |
巴斯德毕赤酵母 | 甲醇 | MM,发酵罐, 300 mL发酵体积 | 48.2 | 23.0 | 3.7 | [ | |
L-乳酸 | 蓝细菌 | CO2 | MM,摇瓶, 80 mL发酵体积 | 1.0 | N.D. | 0.03 | [ |
甲烷氧化菌 | 甲烷 | MM,摇瓶, 2 mL发酵体积 | 0.6 | N.D. | 0.15 | [ | |
多形汉逊酵母 | 甲醇 | MM,摇瓶, 50 mL发酵体积 | 3.8 | 8.0 | 0.69 | [ | |
D-乳酸 | 蓝细菌 | CO2 | MM,发酵罐, 100 mL发酵体积 | 1.3 | N.D. | 0.13 | [ |
甲基单胞菌 | 甲烷 | MM,摇瓶, 12.5 mL发酵体积 | 1.2 | 24.5 | 0.20 | [ | |
巴斯德毕赤酵母 | 甲醇 | CM,摇瓶, 5 mL发酵体积 | 3.5 | 22.0 | 0.87 | [ | |
琥珀酸 | 蓝细菌 | CO2 | MM,发酵罐, 发酵体积未知 | 0.93 | N.D. | 0.19 | [ |
蓝细菌 | CO2 | MM,摇瓶, 40 mL发酵体积 | 0.63 | N.D. | 0.32 | [ | |
蓝细菌 | CO2 | MM,摇瓶, 发酵体积未知 | 1.8 | N.D. | 0.60 | [ | |
蓝细菌 | CO2 | MM,发酵罐, 1 L发酵体积 | 2.5 | N.D. | 0.23 | [ | |
甲基单胞菌 | 甲烷 | MM,发酵罐, 3.2 L发酵体积 | 0.20 | 7.9 | 0.04 | [ |
Fig. 2 Biosynthetic pathway and engineering strategies for 3-HP production from C1 feedstocksZWF1:Glucose-6-Phosphate Dehydrogenase Gene; GND1: 6-Phosphogluconate Dehydrogenase Gene; EcPDH: Escherichia coli Pyruvate Dehydrogenase Complex Gene; ACC1: Acetyl-CoA Carboxylase Gene; FAA1: Fatty Acyl-CoA Synthetase Gene; POX1: Fatty Acyl-CoA Oxidase Gene; FAS: Fatty Acid Synthase Gene; MmACL: Mouse ATP-Citrate Lyase Gene; ScIDP2: Saccharomyces cerevisiae Isocitrate Dehydrogenase Gene; MCR-C: Malonyl-CoA Reductase C-Terminal Gene; MCR-N: Malonyl-CoA Reductase N-Terminal Gene
Fig. 3 Biosynthetic pathway and engineering strategies for lactic acid production from C1 feedstocksGPD1/2: Glycerol-3-Phosphate Dehydrogenase 1/2 Genes; ADH: Alcohol Dehydrogenase Gene; PDC1/5/6: Pyruvate Decarboxylase 1/5/6 Genes; ALDH: Aldehyde Dehydrogenase Gene; L-LDH: L-Lactate Dehydrogenase Gene; D-LDH: D-Lactate Dehydrogenase Gene; CYB2: L-Lactate Dehydrogenase (Cytochrome) Gene; DLD1: D-Lactate Dehydrogenase Gene; Ady2: Acetate Transporter; Jen1: Monocarboxylate/H+ Symporter; LldP: D-Lactate Transporter
Fig. 4 Biosynthetic pathway and engineering strategies for succinic acid production from C1 feedstocksPYC: Pyruvate Carboxylase Gene; PPC: Phosphoenolpyruvate Carboxylase Gene; PCK: Phosphoenolpyruvate Carboxykinase Gene; MAE: Malic Enzyme Gene; MDH: Malate Dehydrogenase Gene; FUM: Fumarase Gene; FRD: Fumarate Reductase Gene; SDH: Succinate Dehydrogenase Gene
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