基于合成生物学的替代蛋白产业专利分析

doi:10.12211/2096-8280.2025-092

合成生物学

• 研究论文 •

基于合成生物学的替代蛋白产业专利分析

刘亚男²^,³, 王可²^,³, 刘书彤²^,³, 王英²^,³, 李金娜²^,³, 王聪²^,³, 孟宇²^,³, 吴崇明¹^,²

^1.中国科学院天津工业生物技术研究所天津 300308
^2.国家合成生物技术创新中心天津 300308
^3.天津国家合成生物技术创新中心有限公司天津 300308

收稿日期:2025-09-26 修回日期:2025-11-04 出版日期:2025-11-06
通讯作者: 王聪,孟宇,吴崇明
作者简介:刘亚男（1988—），女，知识产权师，硕士。研究方向为合成生物领域专利布局、知识产权导航、运营、保护等。E-mail：liuyanan@ncsynbio.com
王聪（1991—），男，高级知识产权师，硕士。研究方向为合成生物领域知识产权导航、布局、运营、保护等。E-mail：wangcong@ncsynbio.com
孟宇（1985—），男，硕士，副总经理。研究方向为合成生物技术转移转化战略研究。E-mail：mengyu@ncsynbio.com
吴崇明（1984—），女，高级工程师，硕士，信息情报中心负责人。研究方向为生物制造领域科技战略与信息情报研究。E-mail：wu_cm@tib.cas.cn
基金资助:
中国科学院发展规划局“重大科技项目专利导航”项目资助(XD-ZLDH-1-01)

Patent Analysis of the Alternative Protein Industry Based on Synthetic Biology

Liu Yanan²^,³, Wang Ke²^,³, Liu Shutong²^,³, Wang Ying²^,³, Li Jinna²^,³, Wang Cong²^,³, Meng Yu²^,³, Wu Chongming¹^,²

^1.Tianjin Institute of Industrial Biotechnology，Chinese Academy of Sciences，Tianjin 300308，China
^2.National Center of Technology Innovation for Synthetic Biology，Tianjin 300308，China
^3.Tianjin National Center of Technology Innovation for Synthetic Biology Co. ，Ltd. ，Tianjin 300308，China

Received:2025-09-26 Revised:2025-11-04 Online:2025-11-06
Contact: Wang Cong, Meng Yu, Wu Chongming

摘要/Abstract

摘要：

替代蛋白产业作为应对全球粮食安全与可持续发展挑战的新路径、新业态，正迎来快速发展与技术迭代。在全球蛋白危机将至的背景下，中国如何抓住替代蛋白这一战略机遇，通过有前瞻性的原始技术创新和高质量的专利布局，逐步转变为未来的技术和产业领导者是我们面临的现实问题。研究显示，中国在专利申请量与增速上已跃居全球领先地位，但在基础性与平台型技术储备、创新策源结构方面仍存挑战。本文首先系统剖析了全球蛋白危机与替代蛋白兴起的时代背景，继而全景式扫描了全球及中国产业发展与竞争格局，再通过专利数据分析，聚焦于单细胞蛋白、细胞培养肉、植物分子农业蛋白，为中国加速发展替代蛋白产业提出了系统性的技术创新与专利布局建议，如构建基础专利体系以突破关键平台技术，强化全球专利布局，提升国际竞争能力等。

关键词: 替代蛋白, 单细胞蛋白, 微生物蛋白, 专利分析, 合成生物学

Abstract:

Driven by an intensifying global protein shortfall, the alternative-protein sector has entered a phase of rapid capacity expansion and iterative technological upgrading. China now leads in both absolute volume and annual growth of alternative-protein patent applications, yet remains under-represented in high-value patent families and overseas jurisdictions, constraining its international competitiveness. This paper first dissects the global protein crisis and the consequent rise of alternative proteins. It then provides a panoramic scan of worldwide and domestic industrial landscapes and competitive dynamics. Finally, by applying a big-data patent lens to three technology tracks—single-cell protein, cell-cultured meat and plant molecular agriculture—the study offers a systematic roadmap of technological innovation and patent landscape designed. Our focus is on analyzing global patent filing trends and mapping the development of specific fields to identify major players. The study includes a detailed breakdown of leading companies' patent portfolios, assessing their volume and key technological areas. Based on these analyses, several recommendations are proposed to accelerate the development of China's alternative protein industry, such as establishing a foundational patent system to breakthrough key platform technologies, strengthening global patentllandscape, and enhancing international competitiveness.While a global leader in patent volume, China's alternative protein sector must navigate a crucial strategic repositioning to evolve from a patent giant into an industrial leader. Future strategy should be built on three pillars: cultivating high-value patents with global protection, particularly for critical attributes like safety and efficacy, to ensure regulatory compliance and international market access; fostering an enterprise-driven innovation ecosystem that rapidly translates research and experimental development into market-ready solutions through full industry chain collaboration; and actively participating in global governance to transition from a technology adopter to a co-architect of international standards and regulations. Achieving this will solidify China's pivotal role in the global alternative protein landscape, directly contributing to national food security and low-carbon development goals.

Key words: Alternative protein, Single-cell protein, Microbial protein, Patent analysis, Synthetic biology

中图分类号:

Q816

刘亚男, 王可, 刘书彤, 王英, 李金娜, 王聪, 孟宇, 吴崇明. 基于合成生物学的替代蛋白产业专利分析[J]. 合成生物学, DOI: 10.12211/2096-8280.2025-092.

Liu Yanan, Wang Ke, Liu Shutong, Wang Ying, Li Jinna, Wang Cong, Meng Yu, Wu Chongming. Patent Analysis of the Alternative Protein Industry Based on Synthetic Biology[J]. Synthetic Biology Journal, DOI: 10.12211/2096-8280.2025-092.

图/表 16

图2-1 替代蛋白产业全球专利申请趋势和在华专利申请趋势

Fig. 2-1 Global patent application trends in the alternative protein industry and patent filing trends in china

图2-3 替代蛋白产业全球专利主要技术来源国家/地区和近五年主要技术来源国家/地区

Fig. 2-3 Major technology source countries/regions for global patents in the alternative protein industry and the leading technology source countries/regions in the past five years

图2-2 替代蛋白产业全球专利主要技术目标国家/地区和近五年主要技术目标国家/地区

Fig. 2-2 Key Technology target countries /regions for global patent applications in the alternative protein industry and the key technology target countries /regions in the past five year

图2-4 替代蛋白产业全球专利主要技术构成和近五年主要技术构成

Fig. 2-4 Main technology components of global patents in the alternative protein industry and the key technology components in the past five years

图3-2 菌体蛋白技术发展演进路径

Fig.3-2 Evolution path of microbial protein technology

图3-1 菌体蛋白细分领域全球专利申请趋势和在华专利申请趋势

Fig. 3-1 Global patent filing trends and patent filing trends in china within the microbial protein segment

图3-3 细菌菌体蛋白产业全球专利重要申请人

Fig. 3-3 Key patent applicants in bacterial single-cell protein industry

图3-4 微藻菌体蛋白产业全球专利重要申请人

Fig. 3-4 Key Patent applicants in the microalgal biomass protein industry

图3-5 真菌蛋白产业全球专利重要申请人

Fig. 3-5 Key patent applicants in the fungal protein industry

图3-6 精准发酵蛋白产业全球专利申请趋势和在华专利申请趋势

Fig. 3-6 Global and china patent application trends in the precision fermentation protein industry

图3-7 乳蛋白产业全球专利重要申请人

Fig. 3-7 Key patent applicants in the dairy protein industry

图3-8 血红素蛋白产业全球专利重要申请人

Fig. 3-8 Key patent applicants in the heme protein industry

图3-9 卵清蛋白产业全球专利重要申请人

Fig 3-9 Key patent applicants in the ovalbumin industry

图3-10 细胞培养肉产业全球专利申请趋势和在华专利申请趋势

Fig. 3-10 Global and china patent application trends in the cell-cultured meat industry

图3-11 细胞培养肉产业全球专利重要申请人

Fig. 3-11 Key patent applicants in the cell-cultured meat industry

图3-12 植物分子农业产业全球专利申请趋势和在华专利申请趋势

Fig. 3-12 Global and china patent application trends in the plant molecular agriculture industry

参考文献 50

[1]	《世界人口展望2024》. https://www.un.org/zh/desa/UN-projects-world-population-to-peak-within-this-century-zh."World Population Prospects 2024".
[2]	联合国食粮组织(FAO)数据. https://www.drc.gov.cn/DocView.aspx?chnid=379&leafid=1338&docid=2908092."Global land use for food production".
[3]	Nirmal N., Anyimadu C.F., Khanashyam A.C., Bekhit A.E.-d.A. and Dhar, B.K. (2025), Alternative Protein Sources: Addressing Global Food Security and Environmental Sustainability. Sustainable Development, 33: 3958-3969.
[4]	Seyed Mehrdad Mirsalami, Mirsalami Mahsa. Advances in genetically engineered microorganisms: Transforming food production through precision fermentation and synthetic biology[J].Future Foods, 2025,11.
[5]	Jhanani R., & Gothandam K. M. (2021).Microbial production of recombinant β-lactoglobulin: A review on challenges and opportunities for precision fermented dairy proteins.Biotechnology Journal, 16(8), 2100085.
[6]	Biermann L, Tadele LR, Benatto Perino EH, Nicholson R, Lilge L, Hausmann R. Recombinant Production of Bovine αS1-Casein in Genome-Reduced Bacillus subtilis Strain IIG-Bs-20-5-1. Microorganisms. 2025 Jan 2;13(1):60.
[7]	Bae HN, Kim GH, Seo SO. Secretory Production of Plant Heme-Containing Globins by Recombinant Yeast via Precision Fermentation. Foods. 2025 Apr 20;14(8):1422.
[8]	Shao Youran, Xue Changlu, Liu Wenqian, Zuo Siqi, Wei Peilian, Lei Huang, Lian Jiazhang, Xu Zhinan.High-level secretory production of leghemoglobin in Pichia pastoris through enhanced globin expression and heme biosynthesis[J].Bioresource Technology, 2022, 363:127884.
[9]	Wang, M., Shi, Z., Gao, N. et al. Sustainable and high-level microbial production of plant hemoglobin in Corynebacterium glutamicum. Biotechnol Biofuels 16, 80 (2023).
[10]	姚斌,徐欣欣,张杰,等.饲用氨基酸的生物合成与产业化应用[J].动物营养学报,2025,37(01):1-14.
	YAO B, XU XX, ZHANG J, et al. Biosynthesis and Industrial Application of Feed Amino Acids9[J], Chinese Journal of Animal Nutrition,2025,37(01):1-14.
[11]	朱永真.重组胶原蛋白的生物制造及其应用[J].中外食品工业,2024,(16):30-32.
	ZHU ZZ. Biomanufacturing and Applications of Recombinant Collagen[J]. Food Industry,2024,(16):30-32.
[12]	Shuaibu A. & Gao, Y. Precision Fermentation: A Tool Revolutionizing the Food Industry-A Review[J]. International Journal of Research and Scientific Innovation, 2024,11(5), 520-530.
[13]	张馥,孙一文,王晓红,等.美国细胞培养肉生产及监管路径分析[J].中国食物与营养,2024,30(08):13-20.
	ZHANG F, SUN Y W, WANG X Het al.Analysis of the Production and Regulatory Pathway for Cell-Cultured Meat in the United States[J].China Food and Nutrition.2024,30(08):13-20.
[14]	陈方,王可,丁陈君.第十二届中国工业生物技术创新论坛暨生物制造产业大会《中国工业生物技术产业发展白皮书 2024》.
	CHEN F, WANG K, DING C J. The 12th China Industrial Biotechnology Innovation Forum and Bio-Manufacturing Industry Conference. "China Industrial Biotechnology Development White Paper 2024"
[15]	国务院《关于践行大食物观构建多元化食物供给体系的意见》. .
	Council's State, "Opinions on Practicing the Broader Food Approach and Building a Diversified Food Supply System"
[16]	农业农村部《全国农业农村科技发展规划》. .
	Ministry of Agriculture and Rural Affairs of the People's Republic of China, "National Agricultural and Rural Science and Technology Development Plan"
[17]	国务院《生物经济发展规划》. https://www.ndrc.gov.cn/xxgk/zcfb/ghwb/202205/t20220510_1324436_ext.html.State Council's, "Bioeconomy Development Plan".
[18]	国家食品安全风险评估中心《关于完善“三新食品”安全性评价资料要求的通知》. .
	China National Center for Food Safety Risk Assessment "Notice on Improving the Data Requirements for Safety Assessment of "Three Novel Foods".
[19]	农业农村部《农业用基因编辑植物评审细则（试行）》. .
	Ministry of Agriculture and Rural Affairs of the People's Republic of China, "Review Guidelines for Gene-Edited Plants in Agriculture (Interim)".
[20]	智研咨询产业研究,《2025-2031年中国替代蛋白行业市场供需态势及发展趋向研判报告》. .
	"Zhiyan Consulting Industrial Research, "China Alternative Protein Industry Market Supply-Demand Situation and Development Trend Insight Report, 2025-2031".
[21]	李兆丰,孔昊存,刘潇,等.新质蛋白:机遇与挑战[J].生物工程学报,2025,41(05):1691-1704.
	LI Z F, KONG H C, LIU X, et al. Novel Proteins: Opportunities and Challenges [J]. Chinese Journal of Biotechnology, 2025,41(05):1691-1704.
[22]	王国坤,蔺玉萍,王钦宏,等.微生物蛋白制造的发展趋势与挑战[J].科学通报,2023,68(21):2779-2789.
	WANG g K, LIN Y P, WANG Q H, et al. Development Trends and Challenges of Microbial Protein Production [J]. Chinese Science Bulletin,2023,68(21):2779-2789.
[23]	Fischer R., & Schillberg S. (2004).Molecular Farming: Plant-Made Pharmaceuticals and Technical Proteins.John Wiley & Sons, Hoboken, NJ.
[24]	Pereira AG, Fraga-Corral M, Garcia-Oliveira P, et al. Single-cellproteins obtained by circular economy intended as a feed ingredientin aquaculture [J]. Foods, 2022, 11(18): 2831.
[25]	Hilgendorf Karson, Wang Yirong, Miller Michael J, Jin Yong-Su,Precision fermentation for improving the quality, flavor, safety, and sustainability of foods,Current Opinion in Biotechnology[J],2024,86:103084
[26]	Lapeña D, Kosa G, Hansen LD, et al. Production andcharacterization of yeasts grown on media composed of spruce-derived sugars and protein hydrolysates from chicken by-products [J].Microb Cell Fact, 2020, 19(1): 19.
[27]	Meng J, Liu SF, Gao L, et al. Economical production of Pichiapastoris single cell protein from methanol at industrial pilot scale [J].Microb Cell Fact, 2023, 22(1): 198.
[28]	Liu KY, Huang SY, Zhang L, et al. Efficient production of single cell protein from biogas slurry using screened alkali-salt-tolerantDebaryomyces hansenii [J]. Bioresour Technol, 2024, 393: 130119.
[29]	白帆,周雍进.酵母单细胞蛋白助力食品工业发展与应用[J].生物技术通报,1-8,2025-10-22.
	BAI F, ZHOU YJ. Yeast Single-Cell Protein: Powering Innovation in the Food Industry[J].Biotechnology Bulletin,,1-8,2025-10-22.
[30]	周光宏,丁世杰,徐幸莲.培养肉的研究进展与挑战[J].中国食品学报,2020, 20(5):1-11.
	ZHOU G H, DING S J, XU X L. Progress and challenges in cultured meat[J]. Journal of Chinese Institute of Food Science and Technology, 2020, 20(5):1-11.
[31]	丁世杰,李春保,周光宏. 细胞培养肉技术及产业化进展与挑战[J].中国食品学报,2022, 22(12):33-41.
	DING S J, LI C B, ZHOU G H. Progress and challenge of cultured meat technology and industrialization[J]. Journal of Chinese Institute of Food Science and Technology, 2022, 22(12):33-41.
[32]	朱浩哲,吴中元,丁希等.利用猪肌肉干细胞进行培养肉生产的研究[J].生物材料, 2022, 287:121650.
	ZHU H Z, WU Z Y, DING X, et al. Production of cultured meat from pig muscle stem cells[J]. Biomaterials, 2022, 287:121650.
[33]	郑欧阳,孙钦秀,刘书成,等.细胞培养肉的挑战与发展前景[J].食品与发酵工业,2021,47(09):314-320.
	ZHENG OY, SUN QX, LIU SC, et al. Challenges and Future of Cell-Cultured Meat [J]. Food and Fermentation Industries,2021,47(09):314-320.
[34]	孙莹,王龙,朱秀清,等.植物基蛋白肉的研究现状与挑战[J].食品工业科技, 2023, 44(17):438-446.
	SUN Y, WANG L, ZHU X Q, et al. Research status and challenge on plant-based protein meat[J]. Science and Technology of Food Industry, 2023, 44(17):438-446.
[35]	张月,王洁,丁世杰,等.细胞培养肉的生物工程学基础与技术进展[J].中国食品学报,2025,25(05):77-85.
	ZHANG Y, WANG H, DING SJet al. Bioengineering basis and technological progress of cell cultured meat[J], Journal of Chinese Institute of Food Science and Technology, 2025,25(05):77-85.
[36]	Otero D.  M., Mendes G. D. L., Lucas A. J., Christ-Ribeiro A., & Ribeiro C. D. F. (2022). Exploring alternative protein sources: Evidence from patents and articles focusing on food markets. Food Chemistry, 394, 133486.
[37]	关欣,汪丹丹,方佳华,等.细胞培养肉技术:研究进展与未来展望[J].中国食品学报,2022,22(12):1-13.
	GUAN X, WANG DD, FANG JH, et al. Cultured Meat Technology: Research Progress and Future Prospects[J]. Journal of Chinese Institute of Food Science and Technology,2022,22(12):1-13.
[38]	Technological Trend and Suggestions for Cultured Meat Industry(技术趋势与对策)食品科学(Food Science), Xin Guan, Zhou Jingwen, Du Guocheng, Jian Chen,2023,38(5):112-120
[39]	Martins Beatriz 1, Arthur Bister1, Richard G.J. Dohmen1,2, Maria Ana Gouveia1et al. Advances and Challenges in Cell Biology for Cultured Meat Trends in Food Science & Technology, 2024,Vol. 12:345-368.
[40]	Zhang Guoqiang, Zhao Xinrui, Li Xueliang, Du Guocheng, Zhou* Jingwen, Jian Chen*. Challenges and possibilities for bio-manufacturing cultured meat. Trends in Food Science &Technology, 2020. 97: 443-450.
[41]	Devdatta M. Malshe. "Patent Pools Competition Law and Biotechnology."Taylor & Francis Group, 2020.
[42]	Elizaveta Osipchuk. "Working Competition and Biotechnology Patent Pools."Stockholm IP Law Review, 2018, Vol. 6, No. 1, pp. 73-94.
[43]	Qing Liu & Larry D. Qiu. International patenting by Chinese residents: Constructing a database of Chinese foreign-oriented patent families. China Economic Review, 2016, 36, 1-12.
[44]	Ng E. T., Singh S., Yap W. S., Tay S. H., & Choudhury D. (2021). Cultured meat - a patentometric analysis. Critical Reviews in Food Science and Nutrition, 63(16), 2738–2748.
[45]	黄俊杰,王洋.中国企业海外知识产权维权问题及对策研究[J].中国发明与专利,2025,22(09):89-96.
	HUANG JJ, WANG Y. Research on the Problems and Countermeasures of Overseas Intellectual Property Rights Protection for Chinese Enterprises[J]. China Invention & Patent,2025,22(09):89-96.
[46]	崔立红,李昶郴.新时代中国知识产权人才培养厘革的底层逻辑与未来面向[J].法学论坛,2025,40(05):130-141.
	CUI LH, LI XB. The Underlying Logic and Future Orientation of the Evolution in Cultivating Intellectual Property [J]. Legal Forum,2025,40(05):130-141.
[47]	姚潇颖.中国战略性新兴产业产学研合作机制与绩效研究[D].华中科技大学,2017.
	YAO XY. The Rationale and Prospects for Reforming IP Talent Cultivation in China's New Era[D]. Huazhong University of Science and Technology, 2017.
[48]	陈伟超,戴丽琼,潘长沛,等.通过产学研结合模式培养应用型生物技术人才探析[J].企业科技与发展,2018,(11):13-15.
	CHEN WC, DAI LQ, PAN CP., at et. Exploring the Cultivation of Applied Biotech Professionals through University-Industry Collaboration[J]. Enterprise Science & Technology, 2018,(11):13-15.
[49]	侯小星,曾乐民,罗军,等.科技成果转化中试基地建设机制、路径及对策研究[J].科技管理研究,2022,42(21):112-119.
	HOU XX, ZENG LM, LYO J et al. Establishing Pilot-Scale Facilities for Science & Technology Outcomes Transformation: Mechanisms, Pathways, and Strategies[J]. Science and Technology Management Research, 2022,42(21):112-119.
[50]	陈围.以成果转化为导向的概念验证中心建设模式研究[J].中国信息界,2025,(06):144-146.
	CHEN W. Development Models for Translation-Oriented Proof-of-Concept Centers[J]. China Information,2025,(06):144-146.

基于合成生物学的替代蛋白产业专利分析

Patent Analysis of the Alternative Protein Industry Based on Synthetic Biology

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