doi:10.12211/2096-8280.2023-030

Synthetic Biology Journal ›› 2023, Vol. 4 ›› Issue (2): 241-243.DOI: 10.12211/2096-8280.2023-030

Previous Articles Next Articles

Received:2023-04-07 Revised:2023-04-12 Online:2023-04-27 Published:2023-04-30

合成生物开启生物医药崭新篇章：预防、诊断与治疗

宋斐¹^,², 蔡志明¹^,², 黄卫人¹^,²

^1.深圳大学第一附属医院，深圳市第二人民医院，泌尿外科，广东深圳 518035
^2.广东省泌尿生殖肿瘤系统生物学与合成生物学重点实验室，广东深圳 518035

作者简介:宋斐：女，副研究员，硕士生导师。主要研究方向为肿瘤细胞生物学与肿瘤微环境，肿瘤创新治疗的基础与应用研究。
蔡志明：男，博士，博士生导师，美国医学与生物工程院院士，欧洲科学院院士，乌克兰国家科学院院士，享受国务院政府特殊津贴专家，国家重点基础研究发展计划首席科学家，国家地方联合肿瘤基因组应用工程实验室主任，国家泌尿男生殖系肿瘤研究中心副主任，国家泌尿外科重点学科带头人，深圳大学泌尿生殖研究所所长，深圳市第二人民医院（深圳大学附属第一医院）首席科学家，深圳华大生命科学研究院副院长，深圳市华大医院（筹）负责人。在现代医院管理、泌尿生殖系统肿瘤研究和转化医学等方面做出了系统性、创新性贡献。
黄卫人：男，研究员，博士生导师。主要研究方向：（1）肿瘤基因组学，应用多组学手段鉴定肿瘤及微环境诊疗标志物，开发相关临床应用；（2）肿瘤类器官，利用体外培养系统还原肿瘤体内生长，药物筛选及耐药机制研究；（3）医学合成生物学，创新肿瘤治疗新方法。

Abstract

CLC Number:

Q819

宋斐, 蔡志明, 黄卫人. 合成生物开启生物医药崭新篇章：预防、诊断与治疗[J]. 合成生物学, 2023, 4(2): 241-243.

References 17

1	ZHAO N, SONG Y, XIE X, et al. Synthetic biology-inspired cell engineering in diagnosis, treatment, and drug development[J]. Signal Transduction and Targeted Therapy, 2023, 8(1): 112.
2	National Academies of Sciences, Engineering, and Medicine. Biodefense in the age of synthetic biology[M]. Washington, D.C.: The National Academies Press, 2019.
3	KANG B C, YUN J Y, KIM S T, et al. Precision genome engineering through adenine base editing in plants[J]. Nature Plants, 2018, 4(7): 427-431.
4	ZENG B Y, LAI Y M, LIU L J, et al. Engineering Escherichia coli for high-yielding hydroxytyrosol synthesis from biobased l-tyrosine[J]. Journal of Agricultural and Food Chemistry, 2020, 68(29): 7691-7696.
5	CHOI H M T, CHANG J Y, TRINH L A, et al. Programmable in situ amplification for multiplexed imaging of mRNA expression[J]. Nature Biotechnology, 2010, 28(11): 1208-1212.
6	GREENBAUM U, DUMBRAVA E I, BITER A B, et al. Engineered T-cell receptor T cells for cancer immunotherapy[J]. Cancer Immunology Research, 2021, 9(11): 1252-1261.
7	余茜, 刘建英, 程功. 蚊媒黄病毒传播机制及疫苗与药物研发进展[J]. 合成生物学, 2023, 4(2): 347-372.
	YU X, LIU J Y, CHENG G. Research progress in mosquito-borne flaviviruses transmission and the development of vaccines and drugs[J]. Synthetic Biology Journal, 2023, 4(2): 347-372.
8	申赵铃, 吴艳玲, 应天雷. 合成生物学与病毒疫苗研发[J]. 合成生物学, 2023, 4(2): 333-346.
	SHEN Z L, WU Y L, YING T L. Synthetic biology and viral vaccine development[J]. Synthetic Biology Journal, 2023, 4(2): 333-346.
9	LIU Q, GUO X, XUN G H, et al. Argonaute integrated single-tube PCR system enables supersensitive detection of rare mutations[J]. Nucleic Acids Research, 2021, 49(13): e75.
10	吕海龙, 王建, 吕浩, 等. 合成生物学在下一代基因诊断技术中的应用进展[J]. 合成生物学, 2023, 4(2): 318-332.
	LV H L, WANG J, LV H, et al. Synthetic biology for next-generation genetic diagnostics[J]. Synthetic Biology Journal, 2023, 4(2): 318-332.
11	马孟丹, 刘宇辰. 合成生物学在疾病信息记录与实时监测中的应用潜力[J]. 合成生物学, 2023, 4(2): 301-317.
	MA M D, LIU Y C. Potential application of synthetic biology in disease information recording and real-time monitoring[J]. Synthetic Biology Journal, 2023, 4(2): 301-317.
12	陈青黎, 童贻刚. 工程噬菌体的合成生物学“智造”[J]. 合成生物学, 2023, 4(2): 283-300.
	CHEN Q L, TONG Y G. Merging the frontiers: synthetic biology for advanced bacteriophage design[J]. Synthetic Biology Journal, 2023, 4(2): 283-300.
13	高纤云,牛灵雪,见妮,等.微生物合成生物学在疾病诊疗上的应用进展[J]. 合成生物学, 2023, 4(2): 263-282.
	GAO X Y, NIU L X, JIAN N, et al. Applications of microbial synthetic biology in the diagnosis and treatment of diseases[J]. Synthetic Biology Journal, 2023, 4(2): 263-282.
14	吴晓昊, 廖荣东, 李飞云, 等. 合成生物学在疾病诊疗中的应用[J]. 合成生物学, 2023, 4(2): 244-262.
	WU X H, LIAO R D, LI F Y, et al. Applications of synthetic biology in disease diagnosis and treatment[J]. Synthetic Biology Journal, 2023, 4(2): 244-262.
15	谢君鸿, 何晶晶, 周鹏辉. 合成生物学与工程化T细胞治疗[J]. 合成生物学, 2023, 4(2): 373-393.
	XIE J H, HE J J, ZHOU P H. Synthetic biology and engineered T cell therapy[J]. Synthetic Biology Journal, 2023, 4(2): 373-393.
16	刘菱, 郑胜杰, 窦汇溪,等. 植入式脑机接口在医疗与科研中的作用与应用[J]. 合成生物学, 2023, 4(2): 407-417.
	LIU L, ZHENG S J, DOU H X, et al. Functions and applications of implantable brain-computer interfaces in medical treatment and scientific research[J]. Synthetic Biology Journal, 2023, 4(2): 407-417.
17	朱骊宇, 赵玉龙, 李伟, 等. 哺乳动物染色体工程研究进展[J]. 合成生物学, 2023, 4(2): 394-406.
	ZHU L Y, ZHAO Y L, LI W, et al. Progress in mammalian chromosome engineering[J]. Synthetic Biology Journal, 2023, 4(2): 394-406.

[1]	Kuanqing LIU, Yiheng ZHANG. Biological degradation and utilization of lignin [J]. Synthetic Biology Journal, 2023, (): 1-14.
[2]	Guomiao ZHAO, Xin YANG, Yuan ZHANG, Jing WANG, Jian TAN, Chao WEI, Nana ZHOU, Fan LI, Xiaoyan WANG. Biofoundry and its industrial application [J]. Synthetic Biology Journal, 2023, 4(5): 892-903.
[3]	Hui LU, Fangli ZHANG, Lei HUANG. Establishment of iBioFoundry for synthetic biology applications [J]. Synthetic Biology Journal, 2023, 4(5): 877-891.
[4]	zhiqiang ZHANG, Yang ZHANG, Weibao QIU, Hairong ZHENG. Progress and prospect of ultrasonic liquid transfer and low-volume liquid transfer technology [J]. Synthetic Biology Journal, 2023, 4(5): 916-931.
[5]	Chenyue ZHANG, Yingqun MA, Xing WANG, Rongzhan FU, Jiwei HUANG, Xiufu HUA, Daidi FAN, Qiang FEI. Progress in the bioconversion of biogas into sustainable aviation fuel [J]. Synthetic Biology Journal, 2023, (): 1-13.
[6]	Mengdan MA, Mengyu SHANG, Yuchen LIU. Application and prospect of CRISPR-Cas9 system in tumor biology [J]. Synthetic Biology Journal, 2023, 4(4): 703-719.
[7]	Tiantian WANG, Hong ZHU, Chen YANG. Development of CRISPRa for metabolic engineering applications in cyanobacteria [J]. Synthetic Biology Journal, 2023, 4(4): 824-839.
[8]	Meili SUN, Kaifeng WANG, Ran LU, Xiaojun JI. Rewiring and application of Yarrowia lipolytica chassis cell [J]. Synthetic Biology Journal, 2023, 4(4): 779-807.
[9]	Han SUN, Jin LIU. Research progress and prospects in lipid metabolic engineering of eukaryotic microalgae [J]. Synthetic Biology Journal, 2023, (): 1-21.
[10]	Qian MENG, Cong YIN, Weiren HUANG. Tumor organoids and research progress in synthetic biology [J]. Synthetic Biology Journal, 2023, (): 1-11.
[11]	Xianyun GAO, Lingxue NIU, Ni JIAN, Ningzi GUAN. Applications of microbial synthetic biology in the diagnosis and treatment of diseases [J]. Synthetic Biology Journal, 2023, 4(2): 263-282.
[12]	Ling LIU, Shengjie ZHENG, Huixi DOU, Xiaojian LI. Functions and applications of implantable brain-computer interfaces in medical treatment and scientific research [J]. Synthetic Biology Journal, 2023, 4(2): 407-417.
[13]	Hailong LV, Jian WANG, Hao LV, Jin WANG, Yong XU, Dayong GU. Synthetic biology for next-generation genetic diagnostics [J]. Synthetic Biology Journal, 2023, 4(2): 318-332.
[14]	Xiaolong TENG, Shuobo SHI. Optimization and development of CRISPR/Cas9 systems for genome editing [J]. Synthetic Biology Journal, 2023, 4(1): 67-85.
[15]	Jingwei LYU, Zixin DENG, Qi ZHANG, Wei DING. Identification of RiPPs precursor peptides and cleavage sites based on deep learning [J]. Synthetic Biology Journal, 2022, 3(6): 1262-1276.

合成生物开启生物医药崭新篇章：预防、诊断与治疗

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References 17

Related Articles 15

Recommended Articles

Metrics

Comments