doi:10.12211/2096-8280.2023-069

Synthetic Biology Journal ›› 2023, Vol. 4 ›› Issue (5): 853-856.DOI: 10.12211/2096-8280.2023-069

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Received:2023-09-25 Revised:2023-09-26 Online:2023-11-15 Published:2023-10-31

合成生物学装备：颠覆生命科技的利器

司同¹, 邢新会²^,³^,⁴

^1.中国科学院深圳先进技术研究院，深圳合成生物学创新研究院，中国科学院定量工程生物学重点实验室，广东深圳 518055
^2.清华大学化学工程系，北京 100084
^3.清华大学合成与系统生物学中心，北京 100084
^4.清华大学深圳国际研究生院生物医药与健康工程研究院，深圳 518055

作者简介:司同（1987—），男，研究员，深圳合成生物研究重大科技基础设施总工艺师。课题组关注自动化合成生物研究的理论、技术、装备和应用，在国内外学术期刊发表论文50多篇，H-index为24，任中国生物工程学会合成生物学分会青年工作组委员等。
邢新会（1965—），男，教授。从事生物化工、生物育种技术及装备等方面科研教学工作，在国内外学术刊物发表论文330多篇，合作著书9 本，译著教材2部，英文专著1 部，多项专利技术已成功进入工业应用。作为清华大学-东京工业大学等多个研究生联合培养项目负责人，为国际化教育发展做出贡献。

Abstract

CLC Number:

司同, 邢新会. 合成生物学装备：颠覆生命科技的利器[J]. 合成生物学, 2023, 4(5): 853-856.

References 16

1	LUCKEY J A, DROSSMAN H, KOSTICHKA A J, et al. High speed DNA sequencing by capillary electrophoresis[J]. Nucleic Acids Research, 1990, 18(15): 4417-4421.
2	SAIKI R K, GELFAND D H, STOFFEL S, et al. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase[J]. Science, 1988, 239(4839): 487-491.
3	张志强, 张扬, 邱维宝, 等. 超声移液及微量移液技术进展和展望[J]. 合成生物学, 2023, 4(5): 916-931.
	ZHANG Z Q, ZHANG Y, QIU W B, et al. Progress and prospect of ultrasonic liquid transfer and low-volume liquid transfer technology[J]. Synthetic Biology Journal, 2023, 4(5): 916-931.
4	秦伟彤, 杨广宇. 微液滴高通量筛选方法的研究与应用进展[J]. 合成生物学, 2023, 4(5): 966-979.
	QIN W T, YANG G Y. Research and application progress of microdroplets high throughput screening methods[J]. Synthetic Biology Journal, 2023, 4(5): 966-979.
5	陈永灿, 司同, 张建志. 自动化合成生物技术在DNA组装与微生物底盘操作中的应用[J]. 合成生物学, 2023, 4(5): 857-876.
	CHEN Y C, SI T, ZHANG J Z. Applications of automated synthetic biotechnology in DNA assembly and microbial chassis manipulation[J]. Synthetic Biology Journal, 2023, 4(5): 857-876.
6	刁志钿, 王喜先, 孙晴, 等. 单细胞拉曼光谱测试分选装备研制及应用进展[J]. 合成生物学, 2023, 4(5): 1020-1035.
	DIAO Z D, WANG X X, SUN Q, et al. Advances and applications of single-cell Raman spectroscopy testing and sorting equipment[J]. Synthetic Biology Journal, 2023, 4(5): 1020-1035.
7	吴玉洁, 刘欣欣, 刘健慧, 等. 基于高通量液相色谱质谱技术的菌株筛选与关键分子定量分析研究进展[J]. 合成生物学, 2023, 4(5): 1000-1019.
	WU Y J, LIU X X, LIU J H, et al. Research progress of strain screening and quantitative analysis of key molecules based on high-throughput liquid chromatography and mass spectrometry[J]. Synthetic Biology Journal, 2023, 4(5): 1000-1019.
8	刘欢, 崔球. 原位电离质谱技术在微生物菌株筛选中的应用进展[J]. 合成生物学, 2023, 4(5): 980-999.
	LIU H, CUI Q. Advances and applications of ambient ionization mass spectrometry in screening of microbial strains[J]. Synthetic Biology Journal, 2023, 4(5): 980-999.
9	孙梦楚, 陆亮宇, 申晓林, 等. 基于荧光检测的高通量筛选技术和装备助力细胞工厂构建[J]. 合成生物学, 2023, 4(5): 947-965.
	SUN M C, LU L Y, SHEN X L, et al. Fluorescence detection-based high-throughput screening systems and devices facilitate cell factories construction[J]. Synthetic Biology Journal, 2023, 4(5): 947-965.
10	白仲虎, 任和, 聂简琪, 等. 高通量平行发酵技术的发展与应用[J]. 合成生物学, 2023, 4(5): 904-915.
	BAI Z H, REN H, NIE J Q, et al. The recent progresses and applications of in-parallel fermentation technology[J]. Synthetic Biology Journal, 2023, 4(5): 904-915.
11	卢挥, 张芳丽, 黄磊. 合成生物学自动化装置iBioFoundry 的构建与应用[J]. 合成生物学, 2023, 4(5): 877-891.
	LU H, ZHANG F L, HUANG L. Establishment of iBioFoundry for synthetic biology applications[J]. Synthetic Biology Journal, 2023, 4(5): 877-891.
12	赵国淼, 杨鑫, 张媛, 等. 生物设施平台及其工业应用[J]. 合成生物学, 2023, 4(5): 892-903.
	ZHAO G M, YANG X, ZHANG Y, et al. Biofoundry and its industrial application[J]. Synthetic Biology Journal, 2023, 4(5): 892-903.
13	胡哲辉, 徐娟, 卞光凯. 自动化高通量技术在天然产物生物合成中的应用[J]. 合成生物学, 2023, 4(5): 932-946.
	HU Z H, XU J, BIAN G K. Application of automated high-throughput technology in natural product biosynthesis[J]. Synthetic Biology Journal, 2023, 4(5): 932-946.
14	马翠, 杨凡, 张君泰, 等. 面向自动化铸造平台的多功能微孔板检测系统[J]. 合成生物学, 2023, 4(5): 1036-1049.
	MA C, YANG F, ZHANG J T, et al. Multifunction microplate reader for automated foundry platform[J]. Synthetic Biology Journal, 2023, 4(5): 1036-1049.
15	LI S, LIAO X H, YU X Y, et al. Combining genetically encoded biosensors with droplet microfluidic system for enhanced glutaminase production by Bacillus amyloliquefaciens [J]. Biochemical Engineering Journal, 2022, 186: 108586.
16	JIAN X J, GUO X J, CAI Z S, et al. Single-cell microliter-droplet screening system (MISS Cell): an integrated platform for automated high-throughput microbial monoclonal cultivation and picking[J]. Biotechnology and Bioengineering, 2023, 120(3): 778-792.

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合成生物学装备：颠覆生命科技的利器

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